Spatial Pattern of Transportation Carbon Emission based on Behavior Zones: Evidence from Beijing,China.

Reducing daily transportation carbon emission is one of themain tasksfor accomplishing low carbon city. Most existing studies have evaluated transportation carbon emission from industrial structure or micro-economic viewpoint, such as the efficiency of public transportation, work and home relationship, and modalchoiceof personal trips, but studies on the general impact of personal behaviors on transportation carbon emission is inadequate. A main reason of this relies on thelack of an appropriate spatial unit for integrating people’s greatlydiversifiedbehaviors. This study proposes the concept of ‘behavior zone’(BZ) based on homogeneous assumption of behaviors, in order to analyze people’s traffic behavior and its carbon emission effect by sub-areas. With a survey analysis of the characteristics of people’s daily trips in Beijing’s sample residential areas, the critical indices of BZ are identified including housing price, development intensity and population density, and access to public transportation. With these indices, Beijing is classified into five BZ types, where the modal choice behaviors of inhabitants are projected. Then the total environmental impact of daily trips is estimated based on carbon emission levels of various traffic modes. The results provide a plenty of implications for low carbon strategies such as intensity control by floor-area-ratios and household densities, and adjustment of public transportation services

The cosmic ray test of MRPCs for the BESIII ETOF upgrade

In order to improve the particle identification capability of the Beijing Spectrometer III (BESIII),t is proposed to upgrade the current endcap time-of-flight (ETOF) detector with multi-gap resistive plate chamber (MRPC) technology. Aiming at extending ETOF overall time resolution better than 100ps, the whole system including MRPC detectors, new-designed Front End Electronics (FEE), CLOCK module, fast control boards and time to digital modules (TDIG), was built up and operated online 3 months under the cosmic ray. The main purposes of cosmic ray test are checking the detectors' construction quality, testing the joint operation of all instruments and guaranteeing the performance of the system. The results imply MRPC time resolution better than 100$ps$, efficiency is about 98$\%$ and the noise rate of strip is lower than 1$Hz/$($scm^{2}$) at normal threshold range, the details are discussed and analyzed specifically in this paper. The test indicates that the whole ETOF system would work well and satisfy the requirements of upgrade

System Design and Optimisation Study on a Novel CCHP System Integrated with a Hybrid Energy Storage System and an ORC

For achieving higher energy transferring efficiency from the resources to the load, the Combined Cooling, Heating, and Power (CCHP) systems have been widely researched and applied as an efficient approach. The key idea of this study is designing a novel structure of a hybrid CCHP system and evaluating its performance. In this research, there is a hybrid energy storage unit enhancing the whole system’s operation flexibility while supplying cooling, heating, and power. An ORC system is integrated into the CCHP system which takes responsibility of absorbing the low-temperature heat source for electricity generation. There are a few research studies focusing on the CCHP systems’ performance with this structure. In order to evaluate the integrated system’s performance, investigation and optimisation work has been conducted with the approaches of experimental studies and modelling simulation. The integrated system’s configuration, the model building process of several key components, the optimisation method, and the case studies are discussed and analysed in this study. The design of the integrated system and the control strategy are displayed in detail. Several sets of dynamic energy demand profiles are selected to evaluate the performance of the integrated system. The simulation study of the system supplying selected scenarios of loads is conducted. A comprehensive evaluation report indicates that the system’s efficiency during each study process differs while supplying different loads. The results include the power supplied by each component, the energy consumed by each type of load, and the efficiency improvements. It is found that the integrated system fully satisfies the selected domestic loads and various selected scenarios of loads with high efficiency. Compared to conventional power plants or CHP systems, the system efficiency enhancement comes from higher amount of recovery waste heat. Especially, the ORC system can absorb the low-temperature heat source for electricity generation. Compared to the original following electrical load (FEL) control strategy, the optimisation process brings overall efficiency improvements. The system’s overall efficiency was increased by from 3%, 3.18%, 2.85%, 17.11%, 8.89%, and 21.7% in the second case studies. Through the whole study, the main challenge lies within the design and the energy management of the integrated system

Epidemiological and genomic analyses of human isolates of Streptococcus suis between 2005 and 2021 in Shenzhen, China

Streptococcus suis (S. suis) is an important food-borne zoonotic pathogen that causes swine streptococcosis, which threatens human health and brings economic loss to the swine industry. Three-quarters of human S. suis infections are caused by serotype 2. A retrospective analysis of human S. suis cases in Shenzhen, a megacity in China, with high pork consumption, between 2005 and 2021 was conducted to understand its genomic epidemiology, pathogen virulence, and drug resistance characteristics. The epidemiological investigation showed that human cases of S. suis in Shenzhen were mainly associated with people who had been in close contact with raw pork or other swine products. Whole-genome sequence analysis showed that 33 human isolates in Shenzhen were dominated by serotype 2 (75.76%), followed by serotype 14 (24.24%), and the most prevalent sequence types (STs) were ST7 (48.48%) and ST1 (39.40%). ST242 (9.09%) and ST25 (3.03%), which were rarely reported, were also found. Phylogenetic analysis showed that the Shenzhen human isolates had close genetic relatedness to isolates from Guangxi (China), Sichuan (China), and Vietnam. We found a new 82 KB pathogenicity island (PAI) in the serotype 2 isolate that may play a role in sepsis. Similarly, a serotype 14 isolate, containing 78 KB PAI, was isolated from a patient presenting with streptococcal toxic shock syndrome (STSLS) who subsequently died. Multi-drug resistance (MDR) was high in human isolates of S. suis from Shenzhen. Most human isolates were resistant to tetracycline, streptomycin, erythromycin, and clindamycin, and 13 isolates had intermediate resistance to penicillin. In conclusion, swine importation from Guangxi, Sichuan, and Vietnam should be more closely monitored, and the use of antibiotics limited to reduce the potential for antimicrobial resistance (AMR)

Case Report: Cancer spectrum and genetic characteristics of a de novo germline POLD1 p.L606M variant-induced polyposis syndrome

Germline variations in the DNA polymerase genes, POLE and POLD1, can lead to a hereditary cancer syndrome that is characterized by frequent gastrointestinal polyposis and multiple primary malignant tumors. However, because of its rare occurrence, this disorder has not been extensively studied. In this report, we present the case of a 22-year-old female patient who had been diagnosed with gastrointestinal polyposis, breast fibroadenoma, multiple primary colorectal cancers, and glioblastoma (grade IV) within a span of 4 years. Next-generation sequencing analysis revealed a germline variant in POLD1 (c.1816C>A; p.L606M). In silico analysis using protein functional predicting software, including SIFT, Polyphen, GERP++, and CADD, further confirmed the pathogenicity of POLD1 p.L606M (classified as ACMG grade Class 4). In line with polymerase deficiency, both rectal cancer and glioblastoma tissues exhibited a high tumor mutation burden, with 16.9 muts/Mb and 347.1 muts/Mb, respectively. Interestingly, the patient has no family history of cancer, and gene examination of both parents confirms that this is a de novo germline variant. Therefore, molecular screening for POLD1 may be necessary for patients with such a cancer spectrum, regardless of their family history

Check on the features of potted 20-inch PMTs with 1F3 electronics prototype at Pan-Asia

The Jiangmen underground neutrino observatory (JUNO) is a neutrino project with a 20-kton liquid scintillator detector located at 700-m underground. The large 20-inch PMTs are one of the crucial components of the JUNO experiment aiming to precision neutrino measurements with better than 3% energy resolution at 1 MeV. The excellent energy resolution and a large fiducial volume provide many exciting opportunities for addressing important topics in neutrino and astro-particle physics. With the container #D at JUNO Pan-Asia PMT testing and potting station, the features of waterproof potted 20-inch PMTs were measured with JUNO 1F3 electronics prototype in waveform and charge, which are valuable for better understanding on the performance of the waterproof potted PMTs and the JUNO 1F3 electronics. In this paper, basic features of JUNO 1F3 electronics prototype run at Pan-Asia will be introduced, followed by an analysis of the waterproof potted 20-inch PMTs and a comparison with the results from commercial electronics used by the container #A and #B