2 research outputs found
Enantioselective and Rapid Rh-Catalyzed Arylation of <i>N</i>‑Tosyl- and <i>N</i>‑Nosylaldimines in Methanol
Enantiomerically
enriched tosyl-protected diarylmethylamines were
rapidly prepared by the asymmetric addition of arylboronic acids to <i>N</i>-tosylaldimines under mild conditions in the presence of
a catalyst prepared in situ from RhÂ(I) and a chiral diene ligand.
This methodology offers access to diarylmethylamines in good yields
with excellent chiral purity at room temperature using MeOH as a solvent
and NEt<sub>3</sub> as a base. Its synthetic utility was demonstrated
by the preparation of (S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline
(<b>14</b>), an antagonist of the <i>N</i>-methyl-d-aspartate (NMDA) receptor
Enantioselective and Rapid Rh-Catalyzed Arylation of <i>N</i>‑Tosyl- and <i>N</i>‑Nosylaldimines in Methanol
Enantiomerically
enriched tosyl-protected diarylmethylamines were
rapidly prepared by the asymmetric addition of arylboronic acids to <i>N</i>-tosylaldimines under mild conditions in the presence of
a catalyst prepared in situ from RhÂ(I) and a chiral diene ligand.
This methodology offers access to diarylmethylamines in good yields
with excellent chiral purity at room temperature using MeOH as a solvent
and NEt<sub>3</sub> as a base. Its synthetic utility was demonstrated
by the preparation of (S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline
(<b>14</b>), an antagonist of the <i>N</i>-methyl-d-aspartate (NMDA) receptor