8 research outputs found
Non-alcoholic fatty liver disease is closely associated with sub-clinical inflammation: a case-control study on Asian Indians in North India.
OBJECTIVES: Association between sub-clinical inflammation and non-alcoholic fatty liver disease (NAFLD) has not been studied in Asian Indians. In this case-control study, we aimed to analyse association of NAFLD with the sub-clinical inflammation and metabolic profile in Asian Indians in north India. METHODS: Ultrasound diagnosed 120 cases of NAFLD were compared to 152 healthy controls without NAFLD. Anthropometric profile [body mass index (BMI), waist circumference (WC), hip circumference (HC)], high-sensitivity C-reactive protein (hs-CRP), metabolic profile [fasting blood glucose (FBG), lipid profile] and hepatic function tests [alanine aminotransferase (ALT) and aspartate aminotransferase (AST)] were recorded. RESULTS: Metabolic parameters [FBG, total cholesterol (TC), serum triglycerides (TG),low-density lipoprotein (LDL-c)], hs-CRP and prevalence of the metabolic syndrome were higher in cases as compared to controls (p-value<0.05 for all). The median (range) of hs-CRP (mg/L) for cases [2.6(0.2-13.4)] were significantly higher than in controls [1.4(0.03-11.4), pβ=β0.01]. Similarly, higher values of hs-CRP were obtained when subgroups of cases with obesity, abdominal obesity and the metabolic syndrome were compared to controls [2.75 (0.03-14.3) vs. 1.52 (0.04-14.3), pβ=β0.0010; 2.8 (0.03-14.3) vs. 1.5 (0.06-14.3), pβ=β0.0014 and 2.7 (0.5-14.3) vs. 1.6 (0.06-8.5), pβ=β0.0013, respectively. On multivariate logistic regression analysis BMI (pβ=β0.001), WC (pβ=β0.001), FBG (pβ=β0.002), TC (pβ=β0.008), TG (pβ=β0.002), blood pressure (pβ=β0.005), metabolic syndrome (pβ=β0.001) and hs-CRP (pβ=β0.003) were significantly and independently associated with NAFLD. After adjusting for significant variables, the association between high hs-CRP and NAFLD remained large and statistically significant [adjusted ORβ=β1.17, 95% confidence interval (CI)β=β1.05-1.29]. An increase in 1 mg/dl of hs-CRP level calculated to increase the risk of developing NAFLD by 1.7 times as compared to controls after adjusting for significant variables associated with NAFLD. CONCLUSIONS: In this cohort of Asian Indians in North India, presence of NAFLD showed independent relationships with sub-clinical inflammation
Box plot representation of hs-CRP levels in subjects with non-alcoholic fatty liver disease and in controls having overweight and obesity (a), abdominal obesity (b), and the metabolic syndrome (c).
<p>Each box comprises the values between the 25<sup>th</sup> and the 75<sup>th</sup> percentiles, and the bold horizontal line is the median value; the whiskers stretch from the 10<sup>th</sup> and to the 90<sup>th</sup> percentile. Circles represent individual outlier's value. Stars represent extremes value of individual.</p
Distribution of hs-CRP According to Presence of Impaired Fasting Glucose, Body Mass Index and the Metabolic Syndrome.
*<p>p<0.05.</p
Logistic Regression Analysis with hs-CRP as the Outcome Variable and Anthropometric and Metabolic Variables as Co-variates.
<p>Logistic Regression Analysis with hs-CRP as the Outcome Variable and Anthropometric and Metabolic Variables as Co-variates.</p