Correlations of mutations and increases in and copy number to gefitinib response in a retrospective analysis of lung cancer patients-0

<p><b>Copyright information:</b></p><p>Taken from "Correlations of mutations and increases in and copy number to gefitinib response in a retrospective analysis of lung cancer patients"</p><p>http://www.biomedcentral.com/1471-2407/7/128</p><p>BMC Cancer 2007;7():128-128.</p><p>Published online 13 Jul 2007</p><p>PMCID:PMC1952070.</p><p></p>ur with in-frame exon 19 deletions impacting L747-A750, four with a variety of exon 20 point mutations, and one with an exon 21 point mutation, L858R. Two previously documented synonymous polymorphisms were detected in this study, G2607A in exon 20 (rs10251977) and T2955C in exon 23 (rs17290643). Amino acid numbering is from the initial methionine residue of the protein isoform a (NCBI accession NP_005219)