Liturgy, imagination and poetic language : a study of David Jones's The Anathemata.

The thesis seeks to attempt an examination of David Jones's long poem The Anathemata primarily from a theologically informed standpoint. It sets out to understand, from the literary-critical point of view, the forces and influences that have come together in order to make the poem. At the same time, it is aware of and tries to explore the theological, liturgical and mythological material which provides Jones with both the background to and the content of his poem. It is argued that the form of poem, its linguistic content and the experience of reading it, are best understood in terms of pilgrimage and that such a metaphor is best suited to encompass both its huge scale and its attention to detail. From an overall examination of the available secondary literature, the thesis proceeds examine something of the experience of reading the poem, whether or not the poem can be conveniently understood as an epic and what Jones himself thought he was doing, at the same time his own theoretical stance is illuminated by reference to other contemporary thinkers. An extensive examination of the terms 'myth' and 'anamnesis' and the backgrounds and links between the two both in general and within the context of the poem precede chapters which explore the language of the poem both in terms of stylistic features and also in terms of the literary sources on which Jones draws and which make up the intertexual space within which the poem exists. These matters are further examined in a discussion of the most significant themes with which the poet works in the course of The Anathemata. Finally, some account is given of the formal shape of the poem before a 'commentary' or 'paraphrase' of the poem draws out, in context, the significant features

Assessing the Value of the OpenOrbiter Program\u27s Research Experience for Undergraduates

This article presents an assessment of the benefits gained by undergraduate students who participated in the OpenOrbiter Small Spacecraft Development Initiative. It provides an overview of the program and its learning objectives, as they apply to undergraduate students. It compares the learning impact between students who participated and those who assumed leadership roles. Qualitative assessment with regard to benefits is also discussed. The article extrapolates from these results to identify program elements that were particularly instrumental in delivering the positive benefits discussed. Finally, future work is discussed

Looking forward to making predictions

As described in the preceding pages, since the BGS was established in 1835, the British population has coped with many challenges. These have ranged from finding resources to fuel the Industrial Revolution, understanding and combating water-borne diseases such as typhoid, the threat of invasion and aerial bombardment, through to modern-day environmental problems and climate change. To help deal with these problems, decisionmakers from governments and other organisations have required our help and advice

Non-locality and quasiclassical reality in Kent's formulation of relativistic quantum theory

We report Adrian Kent's proposed framework for a realist, one-world, Lorentz-invariant formulation of quantum theory. The idea is to postulate a �final boundary condition: in eft�ect, a late-time distribution of mass-energy recording how photons scattered off� macroscopic objects. Nature selects this fi�nal boundary condition with the orthodox late-time Born probability; and this defi�nes the probability space of events, to give a realist quantum theory. We emphasize two topics. First, we consider this formulation's verdicts about traditional locality conditions, such as Outcome Independence and Parameter Independence. Second, we discuss a possible amendment to Kent's proposal that, roughly speaking, allows for the emergence of a quasi-classical history even when mass-energy is shielded or delayed from appearing in the fi�nal boundary condition

Differential effects of energy stress on AMPK phosphorylation and apoptosis in experimental brain tumor and normal brain

<p>Abstract</p> <p>Background</p> <p>AMP-activated protein kinase (AMPK) is a known physiological cellular energy sensor and becomes phosphorylated at Thr-172 in response to changes in cellular ATP levels. Activated AMPK acts as either an inducer or suppressor of apoptosis depending on the severity of energy stress and the presence or absence of certain functional tumor suppressor genes.</p> <p>Results</p> <p>Here we show that energy stress differentially affects AMPK phosphorylation and cell-death in brain tumor tissue and in tissue from contra-lateral normal brain. We compared TSC2 deficient CT-2A mouse astrocytoma cells with syngeneic normal astrocytes that were grown under identical condition <it>in vitro</it>. Energy stress induced by glucose withdrawal or addition of 2-deoxyglucose caused more ATP depletion, AMPK phosphorylation and apoptosis in CT-2A cells than in the normal astrocytes. Under normal energy conditions pharmacological stimulation of AMPK caused apoptosis in CT-2A cells but not in astrocytes. TSC2 siRNA treated astrocytes are hypersensitive to apoptosis induced by energy stress compared to control cells. AMPK phosphorylation and apoptosis were also greater in the CT-2A tumor tissue than in the normal brain tissue following implementation of dietary energy restriction. Inefficient mTOR and TSC2 signaling, downstream of AMPK, is responsible for CT-2A cell-death, while functional LKB1 may protect normal brain cells under energy stress.</p> <p>Conclusion</p> <p>Together these data demonstrates that AMPK phosphorylation induces apoptosis in mouse astrocytoma but may protect normal brain cells from apoptosis under similar energy stress condition. Therefore, using activator of AMPK along with glycolysis inhibitor could be a potential therapeutic approach for TSC2 deficient human malignant astrocytoma.</p

Socially-Sensitive Systems Design:Exploring Social Potential

In human society, individuals have long voluntarily organized themselves in groups, which embody, provide and/or facilitate a range of different social concepts, such as governance, justice, or mutual aid. These social groups vary in form, size, and permanence, but in different ways provide benefits to their members. In turn, members of these groups use their understanding and awareness of group expectations to help determine their own actions, to the benefit of themselves, each other, and the health of the group