Factors Associated with Revision Surgery after Internal Fixation of Hip Fractures

Background: Femoral neck fractures are associated with high rates of revision surgery after management with internal fixation. Using data from the Fixation using Alternative Implants for the Treatment of Hip fractures (FAITH) trial evaluating methods of internal fixation in patients with femoral neck fractures, we investigated associations between baseline and surgical factors and the need for revision surgery to promote healing, relieve pain, treat infection or improve function over 24 months postsurgery. Additionally, we investigated factors associated with (1) hardware removal and (2) implant exchange from cancellous screws (CS) or sliding hip screw (SHS) to total hip arthroplasty, hemiarthroplasty, or another internal fixation device. Methods: We identified 15 potential factors a priori that may be associated with revision surgery, 7 with hardware removal, and 14 with implant exchange. We used multivariable Cox proportional hazards analyses in our investigation. Results: Factors associated with increased risk of revision surgery included: female sex, [hazard ratio (HR) 1.79, 95% confidence interval (CI) 1.25-2.50; P = 0.001], higher body mass index (fo

22nd Francis New Lecture Experiences of the past 25 years and current issues for the European fertiliser industry

Paper presented to the International Fertiliser Society at a meeting in London (GB), 10 May 2001Available from British Library Document Supply Centre-DSC:6732.105(no 480) / BLDSC - British Library Document Supply CentreSIGLEGBUnited Kingdo

Detecting Hotspots in Insulin-Like Growth Factors 1 Research through MetaMap and Data Mining Technologies

Most digital information resources for readers of the medical library exist in the form of unstructured free text (journal papers). Therefore it has become the new direction of data mining research to extract keywords in the collection of medical literature and turn them into structured knowledge that is easily accessible and analyzable. MetaMap, a mapping tool from free text to the UMLS Metathesaurus developed by the U.S. National Library of Medicine, maps keywords to the normative UMLS thesaurus, and provides a rating for the mapping degree of every word. The present study extracts keywords from the English language literature of insulin-like growth factors 1 research, assigns weights to the keywords using the BM25F model, screens out groups of important keywords, carries out a cluster analysis of these keywords.http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000337296200031&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701Computer Science, Information SystemsComputer Science, Software EngineeringComputer Science, Theory & MethodsEICPCI-S(ISTP)

Protein data integration problem

In this chapter, we consider the challenges of information integration in proteomics from the prospective of researchers using information technology as an integral part of their discovery process. Specifically, data integration, meta-data specification, data provenance and data quality, and ontology are discussed here. These are the fundamental problems that need to be solved by the bioinformatics community so that modern information technology can have a deeper impact on the progress of biological discovery