Sibling Closeness and Similarity and the Presence of Perfectionism

This study explored whether characteristics of the sibling relationship are related to the level of perfectionistic tendencies that an individual reports. The framework of this study was based on Tesser\u27s Self-Evaluation Maintenance Model, which says that the effects of comparisons with a close other, such as a sibling, can be mediated in one of three ways: (a) by reducing the closeness of the relationship, (b) by improving one\u27s performance/impeding on the other\u27s performance, or (c) by decreasing the relevance of the performance to one\u27s self-concept (pursuing different areas and interests). Several hypotheses were offered which were based on the presumption that individuals with high levels of closeness and similarity in their sibling relationships might attempt to reduce the effects of sibling comparison by improving their performances. In turn, continually striving for high level of performance might be evident in the form of perfectionistic tendencies. A total of 186 participants completed an online questionnaire containing demographic questions, the Perfectionism Inventory, the Warmth/Closeness composite scale of the Sibling Relationship Questionnaire, and the Sibling Similarity Scale. Results suggest that sibling similarity and closeness are related to perfectionistic tendencies, but in different ways than originally anticipated. In particular, each sibling type (non-twins, identical twins, and fraternal twins) demonstrated a different pattern of relationships with perfectionism, suggesting it is important to consider sibling types when studying sibling relationships

Sibling Closeness and Similarity and the Presence of Perfectionism

This study explored whether characteristics of the sibling relationship are related to the level of perfectionistic tendencies that an individual reports. The framework of this study was based on Tesser\u27s Self-Evaluation Maintenance Model, which says that the effects of comparisons with a close other, such as a sibling, can be mediated in one of three ways: (a) by reducing the closeness of the relationship, (b) by improving one\u27s performance/impeding on the other\u27s performance, or (c) by decreasing the relevance of the performance to one\u27s self-concept (pursuing different areas and interests). Several hypotheses were offered which were based on the presumption that individuals with high levels of closeness and similarity in their sibling relationships might attempt to reduce the effects of sibling comparison by improving their performances. In turn, continually striving for high level of performance might be evident in the form of perfectionistic tendencies. A total of 186 participants completed an online questionnaire containing demographic questions, the Perfectionism Inventory, the Warmth/Closeness composite scale of the Sibling Relationship Questionnaire, and the Sibling Similarity Scale. Results suggest that sibling similarity and closeness are related to perfectionistic tendencies, but in different ways than originally anticipated. In particular, each sibling type (non-twins, identical twins, and fraternal twins) demonstrated a different pattern of relationships with perfectionism, suggesting it is important to consider sibling types when studying sibling relationships

Medical device design for adolescent adherence and developmental goals: a case study of a cystic fibrosis physiotherapy device

Purpose: This study investigates the psychosocial aspects of adolescent medical device use and the impact on adolescent adherence and goals for the transitional years between child and adulthood. Patients and methods: Interviews were carried out with 20 adolescents with cystic fibrosis, investigating adolescent medical device use and experiences in relation to their personal and social lives and development through the adolescent years. The qualitative dataset was thematically examined using a content analysis method. Results: The results show that adolescent users of medical technologies want their independence and capabilities to be respected. Adolescent adherence to medical device use was associated with short- and long-term motivations, where older adolescents were able to comprehend the longer-term benefits of use against short-term inconvenience more acutely than younger adolescents. It was suggested that medical devices could provide a tool for communication with families and clinicians and could support adolescents as they take responsibility for managing their condition. Themes of “fitting into teenage life” and “use in the community” were associated with adolescents' needs to form their own identity and have autonomy. Conclusion: This study shows that adolescent needs regarding medical device use are complex. It provides evidence to suggest that devices designed inclusively for adolescents may lead to improved adherence and also facilitate transition through the adolescent years and achievement of adolescent goals

Capturing user requirements in medical device development: the role of ergonomics

Czerniak, L. / SS. Cyril & Methodius Grad. Clas

Rapid evolution of fluoroquinolone-resistant Escherichia coli in Nigeria is temporally associated with fluoroquinolone use

The genetic basis for antimicrobial resistance was studied in fecal Escherichia coli isolates in a Nigerian community in parallel with antimicrobial use. The results showed that fluoroquinolones, and not chloroquine as has been hypothesized elsewhere, appear to be the selective force for fluoroquinolone-resistant fecal E. coli in this setting. Jennie Crowe and Rebeccah Lijek are student co-authors. --author-supplied descriptio

Blocking NMDAR Disrupts Spike Timing and Decouples Monkey Prefrontal Circuits: Implications for Activity-Dependent Disconnection in Schizophrenia

We employed multi-electrode array recording to evaluate the influence of NMDA receptors (NMDAR) on spike-timing dynamics in prefrontal networks of monkeys as they performed a cognitive control task measuring specific deficits in schizophrenia. Systemic, periodic administration of an NMDAR antagonist (phencyclidine) reduced the prevalence and strength of synchronous (0-lag) spike correlation in simultaneously recorded neuron pairs. We employed transfer entropy analysis to measure effective connectivity between prefrontal neurons at lags consistent with monosynaptic interactions and found that effective connectivity was persistently reduced following exposure to the NMDAR antagonist. These results suggest that a disruption of spike timing and effective connectivity might be interrelated factors in pathogenesis, supporting an activity-dependent disconnection theory of schizophrenia. In this theory, disruption of NMDAR synaptic function leads to dys-regulated timing of action potentials in prefrontal networks, accelerating synaptic disconnection through a spike-timing-dependent mechanism

Medical Device Development: the challenge for ergonomics

High quality, well designed medical devices are necessary to provide safe and effective clinical care for patients as well as to ensure the health and safety of professional and lay device users. Capturing the user requirements of users and incorporating these into design is an essential component of this. The field of ergonomics has an opportunity to assist, not only with this area, but also to encourage a more general consideration of the user during medical device development. A review of the literature on methods for assessing user requirements in engineering and ergonomics found that little published work exists on the ergonomics aspects of medical device development. In particular there is little advice available to developers on which issues to consider during design and development or recommendations for good practice in terms of the methods and approaches needed to capture the full range of user requirements. The Multidisciplinary Assessment of Technology Centre for Healthcare (MATCH) is a research collaboration that is working in conjunction with industrial collaborators to apply ergonomics methods to real case study projects with the ultimate aim of producing an industry-focused guide to applying ergonomics principles in medical device development

Capturing User Requirements in Medical Device Development: The Role of Ergonomics

Measuring and fulfilling user requirements during medical device development will result in successful products that improve patient safety, improve device effectiveness and reduce product recalls and modifications. Medical device users are an extremely heterogeneous group and for any one device the users may include patients, their carers as well as various healthcare professionals. There are a number of factors that make capturing user requirements for medical device development challenging including the ethical and research governance involved with studying users as well as the inevitable time and financial constraints. Most ergonomics research methods have been developed in response to such practical constraints and a number of these have potential for medical device development. Some are suitable for specific points in the device cycle such as contextual inquiry and ethnography, others, such as usability tests and focus groups may be used throughout development. When designing user research there are a number of factors that may affect the quality of data collected including the sample of users studied, the use of proxies instead of real end-users and the context in which the research is performed. As different methods are effective in identifying different types of data, ideally more than one method should be used at each point in development, however financial and time factors may often constrain this

Immunogenicity and efficacy of alphavirus-derived replicon vaccines for respiratory syncytial virus and human metapneumovirus in nonhuman primates

Human respiratory syncytial virus (hRSV) and human metapneumovirus (hMPV) are major causes of illness among children, the elderly, and the immunocompromised. No vaccine has been licensed for protection against either of these viruses. We tested the ability of two Venezuelan equine encephalitis virus-based viral replicon particle (VEE-VRP) vaccines that express the hRSV or hMPV fusion (F) protein to confer protection against hRSV or hMPV in African green monkeys. Animals immunized with VEE-VRP vaccines developed RSV or MPV F-specific antibodies and serum neutralizing activity. Compared to control animals, immunized animals were better able to control viral load in the respiratory mucosa following challenge and had lower levels of viral genome in nasopharyngeal and bronchoalveolar lavage fluids. The high level of immunogenicity and protective efficacy induced by these vaccine candidates in nonhuman primates suggest that they hold promise for further development