Sds22 regulates aurora B activity and microtubule-kinetochore interactions at mitosis

Sds22 defines protein phosphatase 1 location and function at kinetochores and subsequent activity of aurora B in mitosis

Cognitive Neuroscience Perspectives on Language Acquisition and Processing

The earliest investigations of the neural implementation of language started with examining patients with various types of disorders and underlying brain damage. The advent of neuroimaging tools in the twentieth century drastically changed the landscape of the field of the (cognitive) neuroscience of language, expanding the variety and depth of research questions one could ask without being confined to specific populations. Today we have better insights regarding the potential (neuro)cognitive correlates of language and an improved understanding of the neurocognitive consequences of language(s) in the mind/brain. And yet the linking hypotheses between neuroscience on the one hand and language on the other do not offer the level of detail needed to move the field from correlational to explanatory [1]. Thus, any further work that takes a more fine-grained look at both language processing and its neurocognitive substrates is warranted and welcome

Duration and extent of bilingual experience modulate neurocognitive outcomes

The potential effects of bilingualism on executive control (EC) have been heavily debated. One possible source of discrepancy in the evidence may be that bilingualism tends to be treated as a monolithic category distinct from monolingualism. We address this possibility by examining the effects of different bilingual language experiences on brain activity related to EC performance. Participants were scanned (fMRI) while they performed a Flanker task. Behavioral data showed robust Flanker effects, not modulated by language experiences across participants. However, differences in duration of bilingual experience and extent of active language use predicted activation in distinct brain regions indicating differences in neural recruitment across conditions. This approach highlights the need to consider specific bilingual language experiences in assessing neurocognitive effects. It further underscores the utility and complementarity of neuroimaging evidence in this general line of research, contributing to a deeper understanding of the variability reported in the literature

Linguistic immersion and structural effects on the bilingual brain: a longitudinal study

Learning and using additional languages can result in structural changes in the brain. However, the time course of these changes, as well as the factors the predict them, are still not well understood. In this longitudinal study we test the effects of bilingual immersion on brain structure of adult sequential bilinguals not undergoing any language training, who were scanned twice, three years apart. We observed significant increases in grey matter volume in the lower left cerebellum, mean white matter diffusivity in the frontal cortex, and reshaping of the left caudate nucleus and amygdala and bilateral hippocampus. Moreover, both prior length of immersion and L2 age of acquisition were significant predictors of volumetric change in the cerebellum. Taken together, these results indicate that bilingualism-induced neurological changes continue to take place across the lifespan and are strongly related to the quantity and quality of bilingual immersion, even in highly-immersed adult bilingual populations

Redefining bilingualism as a spectrum of experiences that differentially affect brain structure and function

Learning and using an additional language is shown to have an impact on the structure and function of the brain, including in regions involved in cognitive control and the connections between them. However, the available evidence remains variable in terms of the localization, extent and trajectory of these effects. Variability likely stems from the fact that bilingualism has been routinely operationalized as a categorical variable (bilingual/monolingual), whereas it is a complex and dynamic experience with a number of potentially deterministic factors affecting neural plasticity. Here we present the first study investigating the combined effects of experience-based factors (EBFs) in bilingual language use on brain structure and functional connectivity. EBFs include an array of measures of everyday usage of a second language in different types of immersive settings (e.g., amount of use in social settings). Analyses reveal specific adaptations in the brain, both structural and functional, correlated to individual EBFs and their combined effects. Taken together the data show that the brain adapts to be maximally efficient in the processing and control of two languages, although modulated ultimately by individual language experience

Degree of multilingual engagement modulates resting state oscillatory activity across the lifespan

Multilingualism has been demonstrated to lead to a more favorable trajectory of neurocognitive aging, yet our understanding of its effect on neurocognition across the lifespan remains limited. We collected resting state EEG recordings from a sample of multilingual individuals across a wide age range. Additionally, we obtained data on participant multilingual language use patterns alongside other known lifestyle enrichment factors. Language experience was operationalized via a modified multilingual diversity (MLD) score. Generalized additive modeling was employed to examine the effects and interactions of age and MLD on resting state oscillatory power and coherence. The data suggest an independent modulatory effect of individualized multilingual engagement on age-related differences in whole brain resting state power across alpha and theta bands, and an interaction between age and MLD on resting state coherence in alpha, theta, and low beta. These results provide evidence of multilingual engagement as an independent correlational factor related to differences in resting state EEG power, consistent with the claim that multilingualism can serve as a protective factor in neurocognitive aging

Review of factors resulting in systemic biases in the screening, assessment, and treatment of individuals at clinical high-risk for psychosis in the United States

BACKGROUND: Since its inception, research in the clinical high-risk (CHR) phase of psychosis has included identifying and exploring the impact of relevant socio-demographic factors. Employing a narrative review approach and highlighting work from the United States, sociocultural and contextual factors potentially affecting the screening, assessment, and service utilization of youth at CHR were reviewed from the current literature. RESULTS: Existing literature suggests that contextual factors impact the predictive performance of widely used psychosis-risk screening tools and may introduce systemic bias and challenges to differential diagnosis in clinical assessment. Factors reviewed include racialized identity, discrimination, neighborhood context, trauma, immigration status, gender identity, sexual orientation, and age. Furthermore, racialized identity and traumatic experiences appear related to symptom severity and service utilization among this population. CONCLUSIONS: Collectively, a growing body of research from the United States and beyond suggests that considering context in psychosis-risk assessment can provide a more accurate appraisal of the nature of risk for psychosis, render more accurate results improving the field\u27s prediction of conversion to psychosis, and enhance our understanding of psychosis-risk trajectories. More work is needed in the U.S. and across the globe to uncover how structural racism and systemic biases impact screening, assessment, treatment, and clinical and functional outcomes for those at CHR

Monolingual comparative normativity in bilingualism research is out of “control”: Arguments and alternatives

Accepted manuscript, to appeared in Applied Psycholinguistics: https://www.cambridge.org/core/journals/applied-psycholinguistics.Herein, we contextualize, problematize and offer some insights for moving beyond the problem of monolingual comparative normativity in (psycho)linguistic research on bilingualism. We argue that, in the vast majority of cases, juxtaposing (functional) monolinguals to bilinguals fails to offer what the comparison is supposedly intended to do: meet the standards of empirical control in line with the scientific method. Instead, the default nature of monolingual comparative normativity has historically contributed to inequalities in many facets of bilingualism research and continues to impede progress on multiple levels. Beyond framing our views on the matter, we offer some epistemological considerations and methodological alternatives to this standard practice that improve empirical rigor while fostering increased diversity, inclusivity and equity in our field

Monolingual comparative normativity in bilingualism research is out of “control”: Arguments and alternatives

Herein, we contextualize, problematize, and offer some insights for moving beyond the problem of monolingual comparative normativity in (psycho) linguistic research on bilingualism. We argue that, in the vast majority of cases, juxtaposing (functional) monolinguals to bilinguals fails to offer what the comparison is supposedly intended to do: meet the standards of empirical control in line with the scientific method. Instead, the default nature of monolingual comparative normativity has historically contributed to inequalities in many facets of bilingualism research and continues to impede progress on multiple levels. Beyond framing our views on the matter, we offer some epistemological considerations and methodological alternatives to this standard practice that improve empirical rigor while fostering increased diversity, inclusivity, and equity in our field.publishedVersio