Causal ACTH-Depot Therapy during Pregnancies following Infertility Treatment

The aim of this paper was to confirm the efficacy of adrenocorticotropin depot (ACTH-depot) therapy in pregnancies with threatened miscarriage and preterm delivery through the desired stimulation of the adrenal glands controlled by the rest of organism. The activity of hypothalamic-pituitary-adrenal axis plays a key role in pregnancy. Such naturally stimulated endogenous corticosteroid hormones are free from unwanted side effects of their synthetics analogs. Low level of maternal blood ACTH and insufficient increase of induced by hypothalamic hormones oxytocinases (cystine-β-aminopeptidases) were indication to ACTH-depot therapy (0.5 mg/week) in our consecutive prospective studies. Contrary to antenatal use of synthetic corticosteroids, there are no temporal limits of this therapy, which has to be more often recommended into clinical prevention of fetal morbidity, treatment of premature delivery, and finally elimination of the newborn's mortality caused by the neuroendocrinological gestoses

Analiza technologii i kosztów produkcji brykietów drzewnych i ich dystrybucja

The paper analyzes the costs of production of wood sawdust briquettes, manufactured by the company Brykiet-Pol2, based in Goleszów in southern Poland. In addition, production technology, raw material supply and distribution of the finished product were analyzed. The costs of producing one ton of briquettes for the four assessed variants ranged from PLN 364.8 (option D) to PLN 648.7 (option A). The cost structure was dominated by the purchase of raw material and depreciation of the technological line. The most economically advantageous production variant was option C, currently implemented in the company (production costs: PLN 458.7·t-1 ), and the proposed option D, using two briquetting presses. The latter option increased production efficiency and reduced unit costs of briquette production in a three-shift system around the clock.W pracy dokonano analizy kosztów produkcji brykietów z trocin drzewnych w przedsiębiorstwie produkcyjno-handlowym Brykiet-Pol2, mającym siedzibę w Goleszowie leżącym w południowej części Polski. Dodatkowo przeanalizowano technologię produkcji, zaopatrzenie w surowiec i dystrybucję wyrobu gotowego. Koszty produkcji jednej tony brykietów dla czterech ocenianych wariantów wahały się od 364,8 PLN (wariant D) do 648,7 PLN (wariant A). W strukturze kosztów dominował zakup surowca oraz amortyzacja linii technologicznej. Najbardziej korzystnym z ekonomicznego punktu widzenia był realizowany w przedsiębiorstwie wariant produkcji C (koszty produkcji 458,7 PLN·t-1 ) oraz proponowany wariant produkcji D. Wtedy wykorzystywane były dwie brykieciarki, co zwiększyło wydajność produkcji i zmniejszyło jednostkowe koszty produkcji brykietów w systemie trzyzmianowym przez całą dobę

Causal ACTH-Depot Therapy during Pregnancies following Infertility Treatment

The aim of this paper was to confirm the efficacy of adrenocorticotropin depot (ACTH-depot) therapy in pregnancies with threatened miscarriage and preterm delivery through the desired stimulation of the adrenal glands controlled by the rest of organism. The activity of hypothalamic-pituitary-adrenal axis plays a key role in pregnancy. Such naturally stimulated endogenous corticosteroid hormones are free from unwanted side effects of their synthetics analogs. Low level of maternal blood ACTH and insufficient increase of induced by hypothalamic hormones oxytocinases (cystine-β-aminopeptidases) were indication to ACTHdepot therapy (0.5 mg/week) in our consecutive prospective studies. Contrary to antenatal use of synthetic corticosteroids, there are no temporal limits of this therapy, which has to be more often recommended into clinical prevention of fetal morbidity, treatment of premature delivery, and finally elimination of the newborn's mortality caused by the neuroendocrinological gestoses