Successful paediatric HIV treatment in rural primary care in Africa

<p>Objective: Clinical outcomes of HIV-infected children on antiretroviral treatment (ART) in a decentralised, nurse/counsellor-led programme.</p> <p>Design: Clinical cohort.</p> <p>Setting: KwaZulu-Natal, South Africa.</p> <p>Patients: HIV-infected children aged <= 15 years on ART, June 2004-2008.</p> <p>Main outcome measures: Survival according to baseline characteristics including age, WHO clinical stage, haemoglobin and CD4%, was assessed in Kaplan-Meier analyses. Hazard ratios for mortality were estimated using Cox proportional hazards regression and changes in laboratory parameters and weight-for-age z scores after 6-12 months' treatment were calculated.</p> <p>Results: 477 HIV-infected children began ART at a median age of 74 months (range 4-180), median CD4 count (CD4%) of 433 cells/mm(3) (17%) and median HIV viral load of log 4.2 copies/ml; 105 (22%) were on treatment for tuberculosis and 317 (76.6%) were WHO stage 3/4. There were significant increases after ART initiation in CD4% (17% vs 22%; p<0.001), haemoglobin (9.9 vs 11.7 g/l; p <= 0.001) and albumin (30 vs 36 g/l; p <= 0.001). 32 (6.7%) children died over 732 child-years of follow-up (43.7 deaths/1000 child-years; 95% CI 32.7 to 58.2), 17 (53.1%) within 90 days of treatment initiation; median age of death was 84 (IQR 10-181) months. Children with baseline haemoglobin <= 8 g/l were more likely to die (adjusted HR 4.5; 95% CI 1.6 to 12.3), as were those aged <18 months compared with >60 months (adjusted HR 3.2; 95% CI 1.2 to 9.1).</p> <p>Conclusions Good clinical outcomes in HIV-infected children on ART are possible in a rural, decentralised service. Few young children are on ART, highlighting the urgent need to identify HIV-exposed infants.</p&gt

Heat transfer to two-phase air/water mixtures flowing in small tubes with inlet disequilibrium

The cooling of gas turbine components was the subject of considerable research. The problem is difficult because the available coolant, compressor bleed air, is itself quite hot and has relatively poor thermophysical properties for a coolant. Injecting liquid water to evaporatively cool the air prior to its contact with the hot components was proposed and studied, particularly as a method of cooling for contingency power applications. Injection of a small quantity of cold liquid water into a relatively hot coolant air stream such that evaporation of the liquid is still in process when the coolant contacts the hot component was studied. No approach was found whereby heat transfer characteristics could be confidently predicted for such a case based solely on prior studies. It was not clear whether disequilibrium between phases at the inlet to the hot component section would improve cooling relative to that obtained where equilibrium was established prior to contact with the hot surface

Monolithic microwave integrated circuit water vapor radiometer

A proof of concept Monolithic Microwave Integrated Circuit (MMIC) Water Vapor Radiometer (WVR) is under development at the Jet Propulsion Laboratory (JPL). WVR's are used to remotely sense water vapor and cloud liquid water in the atmosphere and are valuable for meteorological applications as well as for determination of signal path delays due to water vapor in the atmosphere. The high cost and large size of existing WVR instruments motivate the development of miniature MMIC WVR's, which have great potential for low cost mass production. The miniaturization of WVR components allows large scale deployment of WVR's for Earth environment and meteorological applications. Small WVR's can also result in improved thermal stability, resulting in improved calibration stability. Described here is the design and fabrication of a 31.4 GHz MMIC radiometer as one channel of a thermally stable WVR as a means of assessing MMIC technology feasibility

Exploring prospects of novel drugs for tuberculosis

Tuberculosis remains a disease with an enormous impact on public health worldwide. With the continuously increasing epidemic of drug-resistant tuberculosis, new drugs are desperately needed. However, even for the treatment of drug-sensitive tuberculosis, new drugs are required to shorten the treatment duration and thereby prevent development of drug resistance. Within the past ten years, major advances in tuberculosis drug research have been made, leading to a considerable number of antimycobacterial compounds which are now in the pipeline. Here we discuss a number of these novel promising tuberculosis drugs, as well as the discovery of two new potential drug targets for the development of novel effective drugs to curb the tuberculosis pandemic, ie, the coronin 1 and protein kinase G pathways. Protein kinase G is secreted by mycobacteria and is responsible for blocking lysosomal delivery within the macrophage. Coronin 1 is responsible for activating the phosphatase, calcineurin, and thereby preventing phagosome-lysosome fusion within the macrophage. Blocking these two pathways may lead to rapid killing of mycobacteri

Finite-size scaling of directed percolation above the upper critical dimension

We consider analytically as well as numerically the finite-size scaling behavior in the stationary state near the non-equilibrium phase transition of directed percolation within the mean field regime, i.e., above the upper critical dimension. Analogous to equilibrium, usual finite-size scaling is valid below the upper critical dimension, whereas it fails above. Performing a momentum analysis of associated path integrals we derive modified finite-size scaling forms of the order parameter and its higher moments. The results are confirmed by numerical simulations of corresponding high-dimensional lattice models.Comment: 4 pages, one figur

Prospects for high-resolution microwave spectroscopy of methanol in a Stark-deflected molecular beam

Recently, the extremely sensitive torsion-rotation transitions in methanol have been used to set a tight constraint on a possible variation of the proton-to-electron mass ratio over cosmological time scales. In order to improve this constraint, laboratory data of increased accuracy will be required. Here, we explore the possibility for performing high-resolution spectroscopy on methanol in a Stark-deflected molecular beam. We have calculated the Stark shift of the lower rotational levels in the ground torsion-vibrational state of CH3OH and CD3OH molecules, and have used this to simulate trajectories through a typical molecular beam resonance setup. Furthermore, we have determined the efficiency of non-resonant multi-photon ionization of methanol molecules using a femtosecond laser pulse. The described setup is in principle suited to measure microwave transitions in CH3OH at an accuracy below 10^{-8}

The relation between bar formation, galaxy luminosity, and environment

We derive the bar fraction in three different environments ranging from the field to Virgo and Coma clusters, covering an unprecedentedly large range of galaxy luminosities (or, equivalently, stellar masses). We confirm that the fraction of barred galaxies strongly depends on galaxy luminosity. We also show that the difference between the bar fraction distributions as a function of galaxy luminosity (and mass) in the field and Coma cluster are statistically significant, with Virgo being an intermediate case. We interpret this result as a variation of the effect of environment on bar formation depending on galaxy luminosity. We speculate that brighter disk galaxies are stable enough against interactions to keep their cold structure, thus, the interactions are able to trigger bar formation. For fainter galaxies the interactions become strong enough to heat up the disks inhibiting bar formation and even destroying the disks. Finally, we point out that the controversy regarding whether the bar fraction depends on environment could be resolved by taking into account the different luminosity ranges of the galaxy samples studied so far.Comment: 4 pages, 2 figures. To appear in the proceedings of EWASS 2012 Special Session 4, Structure of galaxy disks shaped by secular evolution and environmental processes, ed. P. Di Matteo and C. Jog, Memorie della Societ\`a Astronomica Italiana Supplement Serie

On Critical Exponents and the Renormalization of the Coupling Constant in Growth Models with Surface Diffusion

It is shown by the method of renormalized field theory that in contrast to a statement based on a mathematically ill-defined invariance transformation and found in most of the recent publications on growth models with surface diffusion, the coupling constant of these models renormalizes nontrivially. This implies that the widely accepted supposedly exact scaling exponents are to be corrected. A two-loop calculation shows that the corrections are small and these exponents seem to be very good approximations.Comment: 4 pages, revtex, 2 postscript figures, to appear in Phys.Rev.Let