Warren Montag, Louis Althusser

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Kompleksowe postepowanie leczenicze nowotowrów gruczołu sutkowego = Comprehensive therapeutic treatments methods of mammary gland carcinoma

Mieszkowski Jan, Pastwik Magdalena, Stejbach Karolina, Przybyłowicz Magdalena, Pijankowska Edyta. Kompleksowe postepowanie leczenicze nowotowrów gruczołu sutkowego = Comprehensive therapeutic treatments methods of mammary gland carcinoma. Journal of Education, Health and Sport. 2015;5(7):314-342. ISSN 2391-8306. DOI 10.5281/zenodo.20068http://ojs.ukw.edu.pl/index.php/johs/article/view/2015%3B5%287%29%3A314-342https://pbn.nauka.gov.pl/works/585127http://dx.doi.org/10.5281/zenodo.20068Formerly Journal of Health Sciences. ISSN 1429-9623 / 2300-665X. Archives 2011–2014 http://journal.rsw.edu.pl/index.php/JHS/issue/archive Deklaracja.Specyfika i zawartość merytoryczna czasopisma nie ulega zmianie.Zgodnie z informacją MNiSW z dnia 2 czerwca 2014 r., że w roku 2014 nie będzie przeprowadzana ocena czasopism naukowych; czasopismo o zmienionym tytule otrzymuje tyle samo punktów co na wykazie czasopism naukowych z dnia 31 grudnia 2014 r.The journal has had 5 points in Ministry of Science and Higher Education of Poland parametric evaluation. Part B item 1089. (31.12.2014).© The Author (s) 2015;This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland and Radom University in Radom, PolandOpen Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non commercialuse, distribution and reproduction in any medium, provided the work is properly cited.The authors declare that there is no conflict of interests regarding the publication of this paper.Received: 15.06.2015. Revised 05.07.2015. Accepted: 12.07.2015. KOMPLEKSOWE POSTEPOWANIE LECZENICZE NOWOTOWRÓW GRUCZOŁU SUTKOWEGOComprehensive therapeutic treatments methods of mammary gland carcinomaMieszkowski Jan1, Pastwik Magdalena2, Stejbach Karolina2, Przybyłowicz Magdalena2, Pijankowska Edyta2  1. Uniwersytet Kazimierza Wielkiego, Bydgoszcz, Polska2. Uniwersytet Mikołaja Kopernika w Toruniu, Collegium Medicum w Bydgoszczy Autor do korespondencji: mgr farm. Jan Mieszkowski e-mail [email protected] Słowa kluczowe: gruczoł sutkowy, kancerogeneza, mammografia, chemioterapia, mastektomia.Key words: mammary gland, carcinogenesis, mammography, chemotherapy, mastectomy. Streszczenie:            Nowotwory piersi są obecnie najczęściej diagnozowanym nowotworem wśród kobiet na świecie, z liczbą nowo zdiagnozowanych zachorowań w 2012 roku na poziomie 1 670 000 pacjentek.  Wśród zgonów z powodu chorób nowotworowych, nowotwór piersi jest pierwszą, w krajach mniej rozwiniętych i drugą (po nowotworach płuc) w krajach rozwiniętych przyczyną zgonów kobiet. W Polsce obserwuje się ciągły wzrost zachorowań na nowotwory piersi. Najczęściej nowotwory piersi wykrywane są u kobiet w wieku 50 - 69 lat, jednak ostatnio obserwowany jest wyraźny wzrost zachorowań u kobiet młodszych.            W ostatnim dwudziestoleciu nowe strategie profilaktyczne pozwalają na wykrywanie rozwoju choroby we wczesnym jej stadium,  zwiększając znacząco szansę pacjentek na dłuższe życie lub wyzdrowienie. Niezmiennie jednak leczenie nowotworów piersi  pozostaje procesem długotrwałym i nie dającym gwarancji na zahamowanie rozwoju zmian chorobowych i wyzdrowienie. Skuteczność terapeutyczna stosowanych metod leczenia jest bardzo zróżnicowana i wymaga każdorazowo indywidualizacji, oraz zastosowania odrębnych strategii leczenia (chirurgia, farmakoterapia, fizjoterapia, psychoterapia), które pozwolą na poprawę ogólnego stanu zdrowia chorego, spowolnienie progresji choroby lub poprawę komfortu życia.            Niniejszy artykuł jest próbą usystematyzowania dostępnych metod diagnostyki i terapii nowotworów piersi ze szczególnym  skupieniem się na kompleksowym podejściem do problemu klinicznego jakim są nowotwory piersi. Ma to na celu lepszego zrozumienie roli wczesnej diagnostyki w przeciwdziałaniu rozwojowi nowotworów piersi oraz konieczności prowadzenia kompleksowych działań leczniczych (współdziałania metod leczenia z zakresu farmacji, fizjoterapii, psychologii) w terapii tego schorzenia. Summary            Breast cancers are now the most commonly diagnosed cancer amongst worldwide women, with the number of newly diagnosed cases 1 670 000 patients (in 2012). Among deaths due to cancer, breast cancer is the first cause of women death in less developed countries and the second (after lung cancer) in developed countries. In Poland continuous increase of breast cancer incidences is being observed. Breast cancers are mostly diagnosed in 50 - 69 years women, but recently the number of breast cancer rates in younger women is increasing.            In the last two decades, new prevention strategies allow the detection of the disease development in its early stages, significantly increasing the chance of patients longer life or full  recovery. However, the treatment of breast cancer remains a long-term process which not gives a guarantee for the inhibition and recovery. The therapeutic efficacy of therapy methods is very diverse and always requires customization, and uses separate treatment strategies (surgery, pharmacotherapy, physiotherapy, psychotherapy), which will improve patient general health, slowing down the disease progression or improving the quality of life.            This article is an attempt to systematize the available diagnosis and treatment methods of breast cancer with a particular focus on a comprehensive approach to this clinical problem. The aim is to better understand the role of early diagnosis in prevention of breast cancer development and the need of a comprehensive approach (interaction of treatments methods in the field of pharmacy, physiotherapy, psychology) in the treatment of this disease

Single high-dose vitamin D supplementation as an approach for reducing ultramarathon-induced inflammation : a double-blind randomized controlled trial

Purpose: A growing number of studies indicate the importance of vitamin D supplementation for sports performance. However, the effects of a single high-dose vitamin D supplementation on ultramarathon-induced inflammation have not been investigated. We here analyzed the effect of a single high-dose vitamin D supplementation on the inflammatory marker levels in ultramarathon runners after an ultramarathon run (maximal run 240 km). Methods: In the study, 35 runners (amateurs) were assigned into two groups: single high-dose vitamin D supplementation group, administered vitamin D (150,000 IU) in vegetable oil 24 h before the start of the run (n = 16); and placebo group (n = 19). Blood was collected for analysis 24 h before, immediately after, and 24 h after the run. Results: Serum 25(OH)D levels were significantly increased after the ultramarathon in both groups. The increase was greater in the vitamin D group than in the control group. Based on post-hoc and other analyses, the increase in interleukin 6 and 10, and resistin levels immediately after the run was significantly higher in runners in the control group than that in those in the supplementation group. Leptin, oncostatin M, and metalloproteinase tissue inhibitor levels were significantly decreased in both groups after the run, regardless of the supplementation. Conclusions: Ultramarathon significantly increases the serum 25(OH)D levels. Attenuation of changes in interleukin levels upon vitamin D supplementation confirmed that vitamin D has anti-inflammatory effect on exercise-induced inflammation

Gross motor coordination and their relationship with body mass and physical activity level during growth in children aged 8-11 years old: a longitudinal and allometric approach

© 2022 The Authors. Published by PeerJ. This is an open access article available under a Creative Commons licence. The published version can be accessed at the following link on the publisher’s website: https://doi.org/10.7717/peerj.13483Background: Gross motor coordination (GMC) is fundamental to the harmonious development of physical skills during the growth of children. This research aimed to explore the developmental changes in GMC during childhood, having controlled for the differences in children's body size and shape using a longitudinal, allometric scaling methodology. Methods: A total of 104 children from North-East Italy of third-fourth- and fifth-grade students and each participant were tested for three consequently years. Subjects performed the short version of korperkoordinationstest fur kinder (KTK3) and the anthropometric characteristics were simultaneously collected. The physical activity questionnaire (PAQ-C) was used to evaluate the weekly physical engagement. Results: Ontogenetic multiplicative models suggested nonlinear associations with GMC across the children's developmental years. Linear physique was a significant predictor associated with the development of GMC across time. PAQ-C was significantly associated with GMC from 8 to 13 years old. Conclusion: Growth does not respect linear trends. A greater lean body mass could be assessed as a reliable predictor of GMC in children. The crucial period of life to improve the GMC is 8-10 years, while stabilization becomes evident from 10 to 13 years.Published onlin

How art constitutes the human : aesthetics, empathy, and the interesting in autofiction

This chapter examines ‘graphic autofiction’ in Lynda Barry’s One! Hundred! Demons! (2002) and What It Is (2009) and Phoebe Gloeckner’s A Child’s Life and Other Stories (2000) and The Diary of A Teenage Girl: An Account in Words and Pictures (2002), demonstrating how it allows feminist performances that visualize cartoonists’ authentic experiences of sexual and other forms of trauma. The chapter makes a valuable contribution to current debates on autofiction by moving beyond its literary expressions and investigating how the hybrid medium of comics accommodates the genre and how that, in its turn, complicates the representation of trauma. It also proposes that ‘graphic autofiction’ allows the formation of feminist counter-narratives to the silencing of female abuse victims and the latter’s representation beyond victimhood