Schematic overview on the standard process of unrelated donor search (black) and the donor center-initiated typing project (red).

<p>*: Both national registries may be identical if donor and patient live in the same country. **: The donor selection process is described in the <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0020268#s2" target="_blank">Methods</a> section. An overview is given in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0020268#pone-0020268-g002" target="_blank">Figure 2</a>.Here, we present results of a project that combines donor center-initiated HLA typing with actual donor searches. We intended to show that this approach is suited to increase chances of patients with ongoing donor searches to find matching donors.</p

Overview on the selection process for donor center-initiated HLA-DRB1 typing.

<p>Overview on the selection process for donor center-initiated HLA-DRB1 typing.</p

Overview on donors who donated stem cells for their respective target patients after donor center-initiated typing.

<p>Mismatches are underlined.</p><p>*: CT result as provided by transplant center.</p

Additional file 6: Figure S5. of 2.7 million samples genotyped for HLA by next generation sequencing: lessons learned

Mean primer dimer rates of HLA loci for different workflows. Error bars show standard deviation. (PDF 5 kb

Additional file 1: Figure S1. of 2.7 million samples genotyped for HLA by next generation sequencing: lessons learned

Prevalence of low-quality samples over time and for different sample provenances (DE, Germany; PL, Poland; UK, United Kingdom). (PDF 5 kb

Additional file 4: of ABO allele-level frequency estimation based on population-scale genotyping by next generation sequencing

Mappings from EAG group codes as used in the JAGS model calculations to the allele groups (AlleleGroupIdentifiers.csv). (CSV 6 kb

Additional file 2: of ABO allele-level frequency estimation based on population-scale genotyping by next generation sequencing

JAGS model specification file (ABO_model.bug). (BUG 38 kb