Substantial and sustained reduction in under-5 mortality, diarrhea, and pneumonia in Oshikhandass, Pakistan : Evidence from two longitudinal cohort studies 15 years apart

Funding Information: Study 1 was funded through the Applied Diarrheal Disease Research Program at Harvard Institute for International Development with a grant from USAID (Project 936–5952, Cooperative Agreement # DPE-5952-A-00-5073-00), and the Aga Khan Health Service, Northern Areas and Chitral, Pakistan. Study 2 was funded by the Pakistan US S&T Cooperative Agreement between the Pakistan Higher Education Commission (HEC) (No.4–421/PAK-US/HEC/2010/955, grant to the Karakoram International University) and US National Academies of Science (Grant Number PGA-P211012 from NAS to the Fogarty International Center). The funding bodies had no role in the design of the study, data collection, analysis, interpretation, or writing of the manuscript. Publisher Copyright: © 2020 The Author(s).Peer reviewedPublisher PD

Measurement of the sum of WW and WZ production with W+dijet events in pp collisions at sqrt(s) = 7 TeV

A measurement of the inclusive WW+WZ diboson production cross section in proton-proton collisions is reported, based on events containing a leptonically decaying W boson and exactly two jets. The data sample, collected at sqrt(s) = 7 TeV with the CMS detector at the LHC, corresponds to an integrated luminosity of 5.0 inverse femtobarns. The measured value of the sum of the inclusive WW and WZ cross sections is sigma(pp to WW+WZ) = 68.9 +/- 8.7 (stat.) +/- 9.7 (syst.) +/- 1.5 (lum.) pb, consistent with the standard model prediction of 65.6 +/- 2.2 pb. This is the first measurement of WW+WZ production in pp collisions using this signature. No evidence for anomalous triple gauge couplings is found and upper limits are set on their magnitudes

Response to Loïc J.D. Wacquant's 'Three Pernicious Premises in the Study of the American Ghetto'

The results of a search for the pair production of a fourth-generation up-type quark (t') in proton-proton collisions at sqrt(s) = 7 TeV are presented, using data corresponding to an integrated luminosity of about 5.0 inverse femtobarns collected by the Compact Muon Solenoid experiment at the LHC. The t' quark is assumed to decay exclusively to a W boson and a b quark. Events with a single isolated electron or muon, missing transverse momentum, and at least four hadronic jets, of which at least one must be identified as a b jet, are selected. No significant excess of events over standard model expectations is observed. Upper limits for the t' anti-t' production cross section at 95% confidence level are set as a function of t' mass, and t'-quark production for masses below 570 GeV is excluded

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field