5 research outputs found

    Non-Newtonian aspects in full film lubrication

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    Additional file 1. Representative experimental hut located at Camp Blanding Joint Training Center, Florida, USA

    MOESM3 of Evaluation of the long-term efficacy of K-Othrine® PolyZone on three surfaces against laboratory reared Anopheles gambiae in semi-field conditions

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    Additional file 3. Graphs showing temperature variations in experimental huts located in full sun, partial sun, and full shade from 20 May 2014 to 20 May 2015. No weather data was collected for the period from 20FEB2015–01APR2015 when no monthly testing was performed. Green = MAX Blue = AVG; Red = MIN

    Plant Growth Regulator Daminozide Is a Selective Inhibitor of Human KDM2/7 Histone Demethylases

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    The JmjC oxygenases catalyze the <i>N</i>-demethylation of <i>N</i><sup>ε</sup>-methyl lysine residues in histones and are current therapeutic targets. A set of human 2-oxoglutarate analogues were screened using a unified assay platform for JmjC demethylases and related oxygenases. Results led to the finding that daminozide (<i>N-</i>(dimethylamino)­succinamic acid, 160 Da), a plant growth regulator, selectively inhibits the KDM2/7 JmjC subfamily. Kinetic and crystallographic studies reveal that daminozide chelates the active site metal via its hydrazide carbonyl and dimethylamino groups
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