A follow-up study of the business graduates of 1948 and 1949 of Cambridge High and Latin School with implications for curriculum revision.

Thesis (Ed.M.)--Boston Universit

CONCEPTUALIZING THE PREVENTION OF HUMAN TRAFFICKING: SURVIVORS PERSPECTIVES

The following study seeks to conceptualize the prevention of human trafficking from the perspective of survivors. The study design was informed through a Public Health Framework and the application of Postmodernism, Social Constructionist Theory, Ecological Perspective and Empowerment Perspective. An integrative mixed-method, participatory research design was applied, namely Concept Mapping. Data was collected over approximately two-months, and included 35 survivors of human trafficking from 4 different states. Data collected from survivors resulted in a statement set (N = 108) and a 10-Cluster Final solution depicting the ways in which survivors conceptualized prevention. Additional outputs provide insight as to survivors’ perspectives on importance and feasibility of the prevention data

Genre-based literacy pedagogy: the nature and value of genre knowledge in teaching and learning writing on a university first year media studies course

A thesis submitted to the Faculty of Humanities, Uniiversity of Luton, in partial fulfilment of the requirements for the degree of Doctor of PhilosophyIn the teaching and learning of literacy, descriptions of text have a problematic status as a result of the growing understanding of literacy as both a cognitive process and a social practice. In the teaching of academic subjects at university, student text is not usually an object of study. The research in this thesis draws on a language based theory oflearning to place textual description at the centre of the teaching and learning of both literacy and academic subjects at university. Participant observation and practice-based research methods were used to implement a form of text-oriented literacy teaching and to explore its compatibility with processes and practices orientations to literacy. Over an eighteen month period, systemic functional grammar was used to investigate and describe the texts of a film studies classroom and the descriptions were used in genre based literacy pedagogy. The effects of the pedagogy are measured in terms of students' performance in an end of course assignment, students' accounts of their writing processes, and student and subject-tutor perception of the text description and the pedagogy. In the thesis, a linguistic description of a key curriculum genre -a Taxonomic Film Analysis -is presented. An account is given of the pedagogy by means of which this essay genre was represented in the film studies classroom as a realisation of choices from linguistic, conceptual and activity systems. Systemic functional grammar-based text description is seen to have provided a means whereby a literacy tutor could collaborate with a subject tutor to provide a subject-specific form of literacy teaching which was evaluated as relevant by students and tutors. The account and the evaluation help to clarify the role that description of text can play in relation to processes and practices ofliteracy use in the teaching and learning of literacy in a film studies classroom and have implications for the teaching and learning of literacy at university more generally

Changing patterns in long-acting bronchodilator trials in chronic obstructive pulmonary disease

Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality worldwide. Developments in the understanding of COPD have led to standard guidelines for diagnosis, treatment, and spirometry assessments, which have in turn influenced trial designs and inclusion criteria. Substantial clinical evidence has been gained from clinical trials and supports a positive approach to COPD management. However, there appear to be changing trends in recent trials. Large bronchodilator studies have reported lower improvements in trough forced expiratory volume in 1 second (FEV1) values versus placebo than were observed in earlier studies, while the rate of FEV1 decline seems to be lower in more recent trials. In addition, recent evidence has called into question the usefulness of bronchodilator reversibility testing as a trial inclusion criterion. Baseline patient populations and use of concomitant medications have also changed over recent years due to increased treatment options. The impact of these many variables on clinical trial results is explored, with a particular focus on changes in inclusion criteria and patient baseline demographics

Applications of neuroimaging to disease-modification trials in Alzheimer's disease.

Critical to development of new therapies for Alzheimer's disease (AD) is the ability to detect clinical or pathological change over time. Clinical outcome measures typically used in therapeutic trials have unfortunately proven to be relatively variable and somewhat insensitive to change in this slowly progressive disease. For this reason, development of surrogate biomarkers that identify significant disease-associated brain changes are necessary to expedite treatment development in AD. Since AD pathology is present in the brain many years prior to clinical manifestation, ideally we want to develop biomarkers of disease that identify abnormal brain structure or function even prior to cognitive decline. Magnetic resonance imaging, fluorodeoxyglucose positron emission tomography, new amyloid imaging techniques, and spinal fluid markers of AD all have great potential to provide surrogate endpoint measures for AD pathology. The Alzheimer's disease neuroimaging initiative (ADNI) was developed for the distinct purpose of evaluating surrogate biomarkers for drug development in AD. Recent evidence from ADNI demonstrates that imaging may provide more sensitive, and earlier, measures of disease progression than traditional clinical measures for powering clinical drug trials in Alzheimer's disease. This review discusses recently presented data from the ADNI dataset, and the importance of imaging in the future of drug development in AD

Dual-Mode Scramjet Flameholding Operability Measurements

Flameholding measurements were made in two different direct connect combustor facilities that were designed to simulate a cavity flameholder in the flowfield of a hydrocarbon fueled dual-mode scramjet combustor. The presence of a shocktrain upstream of the flameholder has a significant impact on the inlet flow to the combustor and on the flameholding limits. A throttle was installed in the downstream end of the test rigs to provide the needed back-pressurization and decouple the operation of the flameholder from the backpressure formed by heat release and thermal choking, as in a flight engine. Measurements were made primarily with ethylene fuel but a limited number of tests were also performed with heated gaseous JP-7 fuel injection. The flameholding limits were measured by ramping inlet air temperature down until blowout was observed. The tests performed in the United Technologies Research Center (UTRC) facility used a hydrogen fueled vitiated air heater, Mach 2.2 and 3.3 inlet nozzles, a scramjet combustor rig with a 1.666 by 6 inch inlet and a 0.65 inch deep cavity. Mean blowout temperature measured at the baseline condition with ethylene fuel, the Mach 2.2 inlet and a cavity pressure of 21 psia was 1502 oR. Flameholding sensitivity to a variety of parameters was assessed. Blowout temperature was found to be most sensitive to fuel injection location and fuel flowrates and surprisingly insensitive to operating pressure (by varying both back-pressurization and inlet flowrate) and inlet Mach number. Video imaging through both the bottom and side wall windows was collected simultaneously and showed that the flame structure was quite unsteady with significant lateral movements as well as movement upstream of the flameholder. Experiments in the University of Virginia (UVa) test facility used a Mach 2 inlet nozzle with a 1 inch by 1.5 inch exit cross section, an aspect ratio of 1.5 versus 3.6 in the UTRC facility. The UVa facility tests were designed to measure the sensitivity of flameholding limits to inlet air vitiation by using electrically heated air and adding steam at levels to simulate vitiated air heaters. The measurements showed no significant difference in blowout temperature with inlet air mole fractions of steam from 0 to 6.7%