Generalized Modified Ratio Estimator for Estimation of Finite Population Mean

A generalized modified ratio estimator is proposed for estimating the population mean using the known population parameters. It is shown that the simple random sampling without replacement sample mean, the usual ratio estimator, the linear regression estimator and all the existing modified ratio estimators are the particular cases of the proposed estimator. The bias and the mean squared error of the proposed estimator are derived and are compared with that of existing estimators. The conditions for which the proposed estimator performs better than the existing estimators are also derived. The performance of the proposed estimator is assessed with that of the existing estimators for certain natural population

Quantum coherence of the Heisenberg spin models with Dzyaloshinsky-Moriya interactions

We study quantum coherence in a spin chain with both symmetric exchange and antisymmetric Dzyaloshinsky-Moriya couplings. Quantum coherence is quantified using the recently introduced quantum Jensen-Shannon divergence, which has the property that it is easily calculable and has several desirable mathematical properties. We calculate exactly the coherence for arbitrary number of spins at zero temperature in various limiting cases. The $\sigma^{z} \sigma^{z}$ interaction tunes the amount of coherence in the system, and the antisymmetric coupling changes the nature of the coherence. We also investigate the effect of non-zero temperature by looking at a two-spin system and and similar behavior, with temperature dampening the coherence. The characteristic behavior of coherence resembles that of entanglement and is opposite to that of discord. The distribution of the coherence on the spins is investigated and found that it arises entirely due to the correlations between the spins.Comment: Accepted for publication in Scientific Report

Lowest Weight Representations, Singular Vectors and Invariant Equations for a Class of Conformal Galilei Algebras

The conformal Galilei algebra (CGA) is a non-semisimple Lie algebra labelled by two parameters $d$ and $\ell$. The aim of the present work is to investigate the lowest weight representations of CGA with $d = 1$ for any integer value of $\ell$. First we focus on the reducibility of the Verma modules. We give a formula for the Shapovalov determinant and it follows that the Verma module is irreducible if $\ell = 1$ and the lowest weight is nonvanishing. We prove that the Verma modules contain many singular vectors, i.e., they are reducible when $\ell \neq 1$. Using the singular vectors, hierarchies of partial differential equations defined on the group manifold are derived. The differential equations are invariant under the kinematical transformation generated by CGA. Finally we construct irreducible lowest weight modules obtained from the reducible Verma modules

Application of PCR-based DNA sequencing technique for the detection of Leptospira in peripheral blood of septicemia patients

Aim: Isolation, dark field detection and microscopic agglutination test (MAT) are considered ―gold standard‖ tests for diagnosis of Leptospirosis. Several PCR assays are reported but very few have been evaluated for detection of Leptospirosis. Therefore, this study was undertaken. This study aims to design and standardize polymerase chain reaction (PCR) - based DNA sequencing technique for the detection of pathogenic Leptospira from peripheral blood of patients clinically diagnosed with septicemia. Methodology and Results: Two hundred and seven (207) blood samples from patients were diagnosed with septicemia which includes 100 bacterial (other than Leptospira) culture positive and 107 bacterial culture negative samples were studied. Primers for Nested PCR targeting LipL32 gene of Leptospira interrogans were designed and the specificity of primers was tested against serum samples positive/negative by either MAT or dark field microscopy. PCR amplified products were further confirmed by DNA sequencing. The standardized nPCR was sensitive and specific to Leptospira interrogans. Twenty-one (21%) out of 100 culture positive blood samples, three (2.8%) out of 107 culture negative samples showed nPCR positivity and were confirmed as Leptospira interrogans by DNA sequencing (p<0.001). A sensitive nPCR specific to Leptospira interrogans was developed. Conclusion, significance and impact of study: The p value (<0.001) signifies that Leptospira is commonly associated with other bacteria circulating in blood indicating that a decreased immune status is created primarily by a bacterium with enhanced possibility of development of Leptospiral infection probably be of an endogenous origin

Dosing pole recommendations for lymphatic filariasis elimination: A height-weight quantile regression modeling approach

BACKGROUND: The World Health Organization (WHO) currently recommends height or age-based dosing as alternatives to weight-based dosing for mass drug administration lymphatic filariasis (LF) elimination programs. The goals of our study were to compare these alternative dosing strategies to weight-based dosing and to develop and evaluate new height-based dosing pole scenarios. METHODOLOGY/PRINCIPAL FINDINGS: Age, height and weight data were collected from \u3e26,000 individuals in five countries during a cluster randomized LF clinical trial. Weight-based dosing for diethylcarbamazine (DEC; 6 mg/kg) and ivermectin (IVM; 200 ug/kg) with tablet numbers derived from a table of weight intervals was treated as the gold standard for this study. Following WHO recommended age-based dosing of DEC and height-based dosing of IVM would have resulted in 32% and 27% of individuals receiving treatment doses below those recommended by weight-based dosing for DEC and IVM, respectively. Underdosing would have been especially common in adult males, who tend to have the highest LF prevalence in many endemic areas. We used a 3-step modeling approach to develop and evaluate new dosing pole cutoffs. First, we analyzed the clinical trial data using quantile regression to predict weight from height. We then used weight predictions to develop new dosing pole cutoff values. Finally, we compared different dosing pole cutoffs and age and height-based WHO dosing recommendations to weight-based dosing. We considered hundreds of scenarios including country- and sex-specific dosing poles. A simple dosing pole with a 6-tablet maximum for both DEC and IVM reduced the underdosing rate by 30% and 21%, respectively, and was nearly as effective as more complex pole combinations for reducing underdosing. CONCLUSIONS/SIGNIFICANCE: Using a novel modeling approach, we developed a simple dosing pole that would markedly reduce underdosing for DEC and IVM in MDA programs compared to current WHO recommended height or age-based dosing

A multi-center, open-labeled, cluster-randomized study of the safety of double and triple drug community mass drug administration for lymphatic filariasis

BackgroundThe Global Programme to Eliminate Lymphatic Filariasis (GPELF) provides antifilarial medications to hundreds of millions of people annually to treat filarial infections and prevent elephantiasis. Recent trials have shown that a single-dose, triple-drug treatment (ivermectin with diethylcarbamazine and albendazole [IDA]) is superior to a two-drug combination (diethylcarbamazine plus albendazole [DA]) that is widely used in LF elimination programs. This study was performed to assess the safety of IDA and DA in a variety of endemic settings.Methods and findingsLarge community studies were conducted in five countries between October 2016 and November 2017. Two studies were performed in areas with no prior mass drug administration (MDA) for filariasis (Papua New Guinea and Indonesia), and three studies were performed in areas with persistent LF despite extensive prior MDA (India, Haiti, and Fiji). Participants were treated with a single oral dose of IDA (ivermectin, 200 μg/kg; diethylcarbamazine, 6 mg/kg; plus albendazole, a fixed dose of 400 mg) or with DA alone. Treatment assignment in each study site was randomized by locality of residence. Treatment was offered to residents who were ≥5 years of age and not pregnant. Adverse events (AEs) were assessed by medical teams with active follow-up for 2 days and passive follow-up for an additional 5 days. A total of 26,836 persons were enrolled (13,535 females and 13,300 males). A total of 12,280 participants were treated with DA, and 14,556 were treated with IDA. On day 1 or 2 after treatment, 97.4% of participants were assessed for AEs. The frequency of all AEs was similar after IDA and DA treatment (12% versus 12.1%, adjusted odds ratio for IDA versus DA 1.15, 95% CI 0.87-1.52, P = 0.316); 10.9% of participants experienced mild (grade 1) AEs, 1% experienced moderate (grade 2) AEs, and 0.1% experienced severe (grade 3) AEs. Rates of serious AEs after DA and IDA treatment were 0.04% (95% CI 0.01%-0.1%) and 0.01% (95% CI 0.00%-0.04%), respectively. Severity of AEs was not significantly different after IDA or DA. Five of six serious AEs reported occurred after DA treatment. The most common AEs reported were headache, dizziness, abdominal pain, fever, nausea, and fatigue. AE frequencies varied by country and were higher in adults and in females. AEs were more common in study participants with microfilaremia (33.4% versus 11.1%, P ConclusionsIn this study, we observed that IDA was well tolerated in LF-endemic populations. Posttreatment AE rates and severity did not differ significantly after IDA or DA treatment. Thus, results of this study suggest that IDA should be as safe as DA for use as a MDA regimen for LF elimination in areas that currently receive DA.Trial registrationClinicaltrials.gov registration number: NCT02899936

A Unique Multi-Agent-Based Approach for Enhanced QoS Resource Allocation in Multi Cloud Environment while Maintaining Minimized Energy and Maximize Revenue

The use of the multi-cloud data storage in one heterogeneous service is a polynimbus cloud strategy. Cloud computing uses a pay-as-you-go model to deliver services to a variety of end users. Customers can outsource daunting tasks to cloud data centres for processing and producing results, thanks to cloud computing. Cloud computing becomes the popular IT brand that provides various on-demand services over the internet. This technology is devoted to distributing computer and software resources. The proven usefulness of workflows to enforce relevant scientific achievements is the availability of data from advanced scientific tools. Scheduling algorithms are essential in order to automate these strenuous workflows efficiently. A number of new heuristics based on a Cloud resource model have been developed. The majority of these heuristic - based address QoS issues in one or two dimensions. The cloud computing technology offers a decentralised pool of services and resources with various models that are provided to the customers across the Internet in an on-demand, continuously distributed, and pay-per-use model. The key challenge we address in this paper is to maximise revenue while maintaining a minimum consumption of energy with an enhanced QoS for resource allocation. The obtained results from proposed method when compared with the existing state of art methods observed to be novel and better