Unsupervised robust nonparametric learning of hidden community properties

We consider learning of fundamental properties of communities in large noisy networks, in the prototypical situation where the nodes or users are split into two classes according to a binary property, e.g., according to their opinions or preferences on a topic. For learning these properties, we propose a nonparametric, unsupervised, and scalable graph scan procedure that is, in addition, robust against a class of powerful adversaries. In our setup, one of the communities can fall under the influence of a knowledgeable adversarial leader, who knows the full network structure, has unlimited computational resources and can completely foresee our planned actions on the network. We prove strong consistency of our results in this setup with minimal assumptions. In particular, the learning procedure estimates the baseline activity of normal users asymptotically correctly with probability 1; the only assumption being the existence of a single implicit community of asymptotically negligible logarithmic size. We provide experiments on real and synthetic data to illustrate the performance of our method, including examples with adversaries.Comment: Experiments with new types of adversaries adde

Apoptotic cell death in the lactating mammary gland is enhanced by a folding variant of α-lactalbumin

Apoptosis is essential to eliminate secretory epithelial cells during the involution of the mammary gland. The environmental regulation of this process is however, poorly understood. This study tested the effect of HAMLET (human α-lactalbumin made lethal to tumor cells) on mammary cells. Plastic pellets containing HAMLET were implanted into the fourth inguinal mammary gland of lactating mice for 3 days. Exposure of mammary tissue to HAMLET resulted in morphological changes typical for apoptosis and in a stimulation of caspase-3 activity in alveolar epithelial cells near the HAMLET pellets but not more distant to the pellet or in contralateral glands. The effect was specific for HAMLET and no effects were observed when mammary glands were exposed to native a-lactalbumin or fatty acid alone. HAMLET also induced cell death in vitro in a mouse mammary epithelial cell line. The results suggest that HAMLET can mediate apoptotic cell death in mammary gland tissu

Beneficiation of Fertilizer Minerals - Saladipura - An Experience

India constitutes approximately one sixth of world's population living in 2% earth's land-mass. The need for increased agricultural out-put by ensuring intensive cultivation can hardly be over emphasised. The most important means of achieving the target is to increase the output of fertilizer minerals and hence chemical fertilizer within the country itself which will enable not only to become self sufficient, but also save fore- ign exchange under widely fluctuating price conditions

Professor DS Kotharis Reflections on the Parallelism between Epistemological Foundations of Modern Physics and Indian Philosophical Thought Part II: The Principle of complementarity and Syadvada

A favourite theme in Prof Kothari's talks and writings during his later years was the close parallelism between Bohr's principle of complementarity and Indian philosophical thought, in particular, the  Syadvada of J ain philosophy 1-6. In this part of the article , we have tried to summarize Prof Kothari's views on the subject

Polynomial time algorithms for multicast network code construction

The famous max-flow min-cut theorem states that a source node s can send information through a network (V, E) to a sink node t at a rate determined by the min-cut separating s and t. Recently, it has been shown that this rate can also be achieved for multicasting to several sinks provided that the intermediate nodes are allowed to re-encode the information they receive. We demonstrate examples of networks where the achievable rates obtained by coding at intermediate nodes are arbitrarily larger than if coding is not allowed. We give deterministic polynomial time algorithms and even faster randomized algorithms for designing linear codes for directed acyclic graphs with edges of unit capacity. We extend these algorithms to integer capacities and to codes that are tolerant to edge failures

Neuronal Activity in the Human Subthalamic Nucleus Encodes Decision Conflict during Action Selection

The subthalamic nucleus (STN), which receives excitatory inputs from the cortex and has direct connections with the inhibitory pathways\ud of the basal ganglia, is well positioned to efficiently mediate action selection. Here, we use microelectrode recordings captured during\ud deep brain stimulation surgery as participants engage in a decision task to examine the role of the human STN in action selection. We\ud demonstrate that spiking activity in the STN increases when participants engage in a decision and that the level of spiking activity\ud increases with the degree of decision conflict. These data implicate the STN as an important mediator of action selection during decision\ud processes.\u

Collaborative care model versus usual care for the management of musculoskeletal and co-existing mental health conditions: a randomised feasibility mixed-methods study.

This study aimed to assess the feasibility of a future trial comparing the collaborative care model with usual care for patients with musculoskeletal conditions and co-existing symptoms of anxiety and depression. A single-centre, parallel-arm, one-to-one, randomised controlled trial design using a mixed-methods approach was used. semistructured interviews and focus groups were conducted post intervention with all participants and staff respectively to explore acceptability towards the model and identify recommendations for improvements. An orthopaedic rehabilitation outpatient tertiary hospital. Adult patients with musculoskeletal conditions and co-existing moderate or severe symptoms of anxiety and depression attending outpatient therapy appointments. The collaborative care model consisted of a tailored management programme to facilitate the integration of care provided by physical and mental healthcare professionals. A case manager screened and coordinated targeted mental health support for participants. Participants allocated to usual care had no support from the case manager. Feasibility indicators (rates of recruitment, randomisation and retention), acceptability of clinical outcome measures, usage of additional resources and cost of intervention implementation. Of the 89 patients who provided consent to take part, 40 participants who matched the eligibility criteria were randomised to either the intervention (n=20) or usual care arm (n=20). Overall adherence to the intervention was 58.82%, while the withdrawal rate was 37.5% at 6 months. All of the 27 participants who were retained completed self-reported outcomes. Qualitative data highlighted that integrated mental health support was favourably perceived. In addition to prenegotiating protected psychology time, the need for operationalised communication between the case manager and clinicians was identified as a recommendation for a future trial. The trial and intervention were acceptable to patients and healthcare professionals. While the findings demonstrate the feasibility of trial recruitment, a future trial will require optimised retention strategies to improve adherence and withdrawal rates. NCT05018039. [Abstract copyright: © Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

Hall Coefficient of Equilibrium Supercurrents Flowing inside Superconductors

We study augmented quasiclassical equations of superconductivity with the Lorentz force, which is missing from the standard Ginzburg-Landau and Eilenberger equations. It is shown that the magnetic Lorentz force on equilibrium supercurrents induces finite charge distribution and the resulting electric field to balance the Lorentz force. An analytic expression is obtained for the corresponding Hall coefficient of clean type-II superconductors with simultaneously incorporating the Fermi-surface and gap anisotropies. It has the same sign and magnitude at zero temperature as the normal state for an arbitrary pairing, having no temperature dependence specifically for the s-wave pairing. The gap anisotropy may bring a considerable temperature dependence in the Hall coefficient and can lead to its sign change as a function of temperature, as exemplified for a model d-wave pairing with a two-dimensional Fermi surface. The sign change may be observed in some high-$T_{c}$ superconductors.Comment: 7 pages, 3 figure

The optic nerve: a new window into cerebrospinal fluid composition?

Cerebrospinal fluid (CSF) pressure and composition are generally thought to be homogeneous within small limits throughout all CSF compartments. CSF sampled during lumbar puncture therefore should be representative for all CSF compartments. On the basis of clinical findings, histology and biochemical markers, we present for the first time strong evidence that the subarachnoid spaces (SAS) of the optic nerve (ON) can become separated from other CSF compartments in certain ON disorders, thus leading to an ON sheath compartment syndrome. This may result in an abnormal concentration gradient of CSF molecular markers determined in locally sampled CSF compared with CSF taken during lumbar punctur