Single inorganic–organic hybrid nanowires with ambipolar photoresponse

We report for the first time single nanowires (NWs) with ambipolar (positive/negative) photoresponse that changes sign depending on the illumination wavelength. The single NWs were grown by the meniscus-guided method using inorganic (ZnO nanoparticles)–organic (PEDOT:PSS) hybrid materials. The ambipolar photoresponse of the single NWs enabled us to develop an unprecedented spectrum-discriminating NW photodetector array

EnCLAP: Combining Neural Audio Codec and Audio-Text Joint Embedding for Automated Audio Captioning

We propose EnCLAP, a novel framework for automated audio captioning. EnCLAP employs two acoustic representation models, EnCodec and CLAP, along with a pretrained language model, BART. We also introduce a new training objective called masked codec modeling that improves acoustic awareness of the pretrained language model. Experimental results on AudioCaps and Clotho demonstrate that our model surpasses the performance of baseline models. Source code will be available at https://github.com/jaeyeonkim99/EnCLAP . An online demo is available at https://huggingface.co/spaces/enclap-team/enclap .Comment: Accepted to ICASSP 202

Light propagation in conjugated polymer nanowires decoupled from a substrate

Light-emitting conjugated polymer nanowires are vertically grown and remotely manipulated into a freestanding straight or curved structure in three-dimension. This approach enabled us to eliminate substrate coupling, a critical issue in nanowire photonics in the past decade. We for the first time accomplished characterization of propagation and bending losses of nanowires completely decoupled from a substrate

Real-time detection of malicious network activity using stochastic models

Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2006.Includes bibliographical references (p. 115-122).This dissertation develops approaches to rapidly detect malicious network traffic including packets sent by portscanners and network worms. The main hypothesis is that stochastic models capturing a host's particular connection-level behavior provide a good foundation for identifying malicious network activity in real-time. Using the models, the dissertation shows that a detection problem can be formulated as one of observing a particular "trajectory" of arriving packets and inferring from it the most likely classification for the given host's behavior. This stochastic approach enables us not only to estimate an algorithm's performance based on the measurable statistics of a host's traffic but also to balance the goals of promptness and accuracy in detecting malicious network activity. This dissertation presents three detection algorithms based on Wald's mathematical framework of sequential analysis. First, Threshold Random Walk (TRW) rapidly detects remote hosts performing a portscan to a target network. TRW is motivated by the empirically observed disparity between the frequency with which connections to newly visited local addresses are successful for benign hosts vs. for portscanners. Second, it presents a hybrid approach that accurately detects scanning worm infections quickly after the infected local host begins to engage in worm propagation.(cont.) Finally, it presents a targeting worm detection algorithm, Rate-Based Sequential Hypothesis Testing (RBS), that promptly identifies high-fan-out behavior by hosts (e.g., targeting worms) based on the rate at which the hosts initiate connections to new destinations. RBS is built on an empirically-driven probability model that captures benign network characteristics. It then presents RBS+TRW, a unified framework for detecting fast-propagating worms independently of their target discovery strategy. All these schemes have been implemented and evaluated using real packet traces collected from multiple network vantage points.by Jaeyeon Jung.Ph.D

Living in a glass house: a survey of private moments in the home

ABSTRACT As advances in technology accelerate, sensors and recording devices are increasingly being integrated into homes. Although the added benefit of sensing is often clear (e.g., entertainment, security, encouraging sustainable behaviors, etc.), the home is a private and intimate place, with multiple stakeholders who may have competing priorities and tolerances for what is acceptable and useful. In an effort to develop systems that account for the needs and concerns of householders, we conducted an anonymous survey (N = 475) focusing on the activities and habits that people do at home that they would not want to be recorded. In this paper, we discuss those activities and where in the home they are performed, and offer suggestions for the design of UbiComp systems that rely on sensing and recording

Comparison of pharmacogenomic information for drug approvals provided by the national regulatory agencies in Korea, Europe, Japan, and the United States

Pharmacogenomics, which is defined as the study of changes in the properties of DNA and RNA associated with drug response, enables the prediction of the efficacy and adverse effects of drugs based on patients’ specific genetic mutations. For the safe and effective use of drugs, it is important that pharmacogenomic information is easily accessible to clinical experts and patients. Therefore, we examined the pharmacogenomic information provided on drug labels in Korea, Europe, Japan, and the United States (US). The selection of drugs that include pharmacogenomic information was based on the drug list that includes genetic information from the Korea Ministry of Food and Drug Safety (MFDS) and US Food and Drug Administration (FDA) websites. Drug labels were retrieved from the sites of MFDS, FDA, European Medicines Agency, and Japanese Pharmaceuticals and Medical Devices Agency. Drugs were classified as per the Anatomical Therapeutic Chemical code, and the biomarkers, labeling sections, and necessity of genetic tests were determined. In total, 348 drugs were selected from 380 drugs with available pharmacogenomic information in Korea and the US after applying the inclusion and exclusion criteria. Of these drugs, 137, 324, 169, and 126 were with pharmacogenomics information in Korea, the US, Europe, and Japan, respectively. The most commonly represented drug class was antineoplastic and immunomodulating agents. Regarding the classification as per the mentioned biomarkers, the cytochrome P450 enzyme was the most frequently mentioned information, and the targeted anticancer drugs most commonly required genetic biomarker testing. The reasons for differences in drug labeling information based on country include differences in mutant alleles according to ethnicity, frequencies at which drug lists are updated, and pharmacogenomics-related guidelines. Clinical experts must continuously strive to identify and report mutations that can explain drug efficacy or side effects for safe drug use