Modeling and Analysis of Re-entrant Production Systems

This paper presents a model and analysis of a re-entrant production line with finite buffers and unreliable machines. Semiconductor device and liquid crystal display (LCD) fabrication processes are characterized as a re-entrant process, in which a similar sequence of processing step is repeated several times. This re-entrant behavior of material flow with the stochastic nature of the system caused by machine failures or demand changes makes the system difficult predict and analyze. The decomposition method analyzes the behavior of the manufacturing systems by decomposing a long transfer line into small analytically tractable components, called two-machine line building blocks. Existing decomposition methods are limited to an in-linear production system without re-entrant flow. Since many manufacturing systems, particularly semiconductor and LCD production lines, consist of re-entrant flow paths, it is essential that models be developed to reflect this. The purpose of this paper is to present mathematical formulations and algorithms to analyze the material behavior of the re-entrant production system using the decomposition method. In developing equations for the two-machine building blocks for the re-entrant production line, we modify the existing decomposition model that has been created for the multiple-part type line. Two main performance measures are evaluated with the developed mathematical model: production rate and average inventory levels for each buffer space in the system. The qualitative behavior of the re-entrant production line under different machine parameters and demand scenarios is also described.Singapore-MIT Alliance (SMA

Modeling and Analysis of Two-Part Type Manufacturing Systems

This paper presents a model and analysis of a synchronous tandem flow line that produces different part types on unreliable machines. The machines operate according to a static priority rule, operating on the highest priority part whenever possible, and operating on lower priority parts only when unable to produce those with higher priorities. We develop a new decomposition method to analyze the behavior of the manufacturing system by decomposing the long production line into small analytically tractable components. As a first step in modeling a production line with more than one part type, we restrict ourselves to the case where there are two part types. Detailed modeling and derivations are presented with a small two-part-type production line that consists of two processing machines and two demand machines. Then, a generalized longer flow line is analyzed. Furthermore, estimates for performance measures, such as average buffer levels and production rates, are presented and compared to extensive discrete event simulation. The quantitative behavior of the two-part type processing line under different demand scenarios is also provided.Singapore-MIT Alliance (SMA

Mathematical modeling and analysis of flexible production lines

Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2007.This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.Includes bibliographical references (p. 165-[166]).We present a model and analysis of a production line that processes different part types on unreliable machines which operate according to a priority rule. The production line consists of machines separated by storage areas in which parts flow in a fixed sequence. A machine operates on the highest priority part whenever possible, and only operates on lower priority parts when unable to produce the higher priority parts. Part priorities are static and are a function only of part type. The purpose of this thesis is to present mathematical formulations and algorithms for estimating production rates and average inventory levels for each part type in a flexible production line. The qualitative behavior of the multiple-part-type line under different supply and demand scenarios is described.by Young Jae Jang.Ph.D

RpS3, a DNA repair endonuclease and ribosomal protein, is involved in apoptosis

AbstractIt is known that mammalian rpS3 functions as a DNA repair endonuclease and ribosomal protein S3. It was also observed that several ribosomal proteins or DNA repair enzymes are related to apoptosis. We report here a third function of rpS3, induction of apoptosis. The localization of green fluorescent protein (GFP)-rpS3 is changed to the nuclear membrane when lymphocytic cells undergo rpS3-induced apoptosis. Transient expression of GFP-rpS3 activates caspase-8/caspase-3 and sensitizes cytokine-induced apoptosis. Deletion analysis reveals that the two functions of rpS3, DNA repair and apoptosis, use independent functional domains

The Light and Period Variations of the Eclipsing Binary BX Draconis

New CCD photometric observations of BX Dra were obtained for 26 nights from 2009 April to 2010 June. The long-term photometric behaviors of the system are presented from detailed studies of the period and light variations, based on the historical data and our new observations. All available light curves display total eclipses at secondary minima and inverse O'Connell effects with Max I fainter than Max II, which are satisfactorily modeled by adding the slightly time-varying hot spot on the primary star. A total of 87 times of minimum light spanning over about 74 yrs, including our 22 timing measurements, were used for ephemeris computations. Detailed analysis of the O-C diagram showed that the orbital period has changed in combinations with an upward parabola and a sinusoidal variation. The continuous period increase with a rate of +5.65 \times 10^-7 d yr^-1 is consistent with that calculated from the Wilson-Devinney synthesis code. It can be interpreted as a mass transfer from the secondary to the primary star at a rate of 2.74 \times 10^-7 M\odot yr^-1, which is one of the largest rates for contact systems. The most likely explanation of the sinusoidal variation with a period of 30.2 yrs and a semi-amplitude of 0.0062 d is a light-traveltime effect due to the existence of a circumbinary object. We suggest that BX Dra is probably a triple system, consisting of a primary star with a spectral type of F0, its secondary component of spectral type F1-2, and an unseen circumbinary object with a minimum mass of M3 = 0.23 M\odot.Comment: 24 pages, including 5 figures and 9 tables, accepted for publication in PAS

Rate-dependent inhomogeneous-to-homogeneous transition of plastic flows during nanoindentation of bulk metallic glasses: Fact or artifact?

There has been considerable controversy over the "apparent" rate-dependent transition from inhomogeneous-to-homogeneous flow during nanoindentation of bulk metallic glasses (BMGs) at room temperature: whether it arises from the existence of homogeneous-flow regime in BMG deformation map or is an artifact due to the instrumental blurring at high rates. To provide a clue to address this dispute, the authors performed nanoindentation experiments on a Zr-based BMG with two geometrically self-similar indenters. The results are discussed in terms of the discrete plasticity ratio, which is a useful parameter in analyzing the contribution of inhomogeneous plasticity to the total plastic deformation.open232

Hepatitis C Virus and Hepatocarcinogenesis

Hepatitis C virus (HCV) is an RNA virus that is unable to integrate into the host genome. However, its proteins interact with various host proteins and induce host responses. The oncogenic process of HCV infection is slow and insidious and probably requires multiple steps of genetic and epigenetic alterations, the activation of cellular oncogenes, the inactivation of tumor suppressor genes, and dysregulation of multiple signal transduction pathways. Stellate cells may transdifferentiate into progenitor cells and possibly be linked to the development of hepatocellular carcinoma (HCC). Viral proteins also have been implicated in several cellular signal transduction pathways that affect cell survival, proliferation, migration and transformation. Current advances in gene expression profile and selective messenger RNA analysis have improved approach to the pathogenesis of HCC. The heterogeneity of genetic events observed in HCV-related HCCs has suggested that complex mechanisms underlie malignant transformation induced by HCV infection. Considering the complexity and heterogeneity of HCCs of both etiological and genetic aspects, further molecular classification is required and an understanding of these molecular complexities may provide the opportunity for effective chemoprevention and personalized therapy for HCV-related HCC patients in the future. In this review, we summarize the current knowledge of the mechanisms of hepatocarcinogenesis induced by HCV infection