Negative emotionality, self-regulation behaviors, and the teacher-child relationship in preschool classrooms

2012 Fall.Includes bibliographical references.This study examines the relationship between levels of negative emotionality, quality of the teacher-child relationship, and self-regulation behaviors in preschool children ages 2.5-5 years (N= 67). It was expected that children with high levels of negative emotionality who experienced a close teacher-child relationship would have higher levels of self-regulation as compared to children with high negative emotionality who had a teacher-child relationship marked with distance or conflict. Negative emotionality and parentally reported self-regulation were assessed using the Child Behavior Questionnaire, teacher-child relationship was measured using the Student-Teacher Relationship Scale, and self-regulation behavior was observed using the Preschool Self -Regulation Assessment. Results were not supportive of the predicted relations among negative affect, student-teacher relationship, and self-regulation. Implications are discussed

The relationship between OCT4 and an aggressive phenotype in triple negative breast cancer (TNBC)

Expected release date-April 201

The relationship between OCT4 and an aggressive phenotype in triple negative breast cancer (TNBC)

Expected release date-April 201

An exploratory study of early childhood coaches’ practices and professional learning needs

Coaching is increasingly being used as a mechanism to improve the quality of early childhood education. Yet, for coaching outside of researcher-controlled interventions, limited information details coaches’ reports of their practices’ professional learning needs. We addressed this gap via an exploratory study utilizing online questionnaires of 91 coaches working with educators in a Midwestern US state across 12 coaching initiatives. Most participants had less than 5 years of experience working as an early childhood coach. Almost a third coached for multiple initiatives. Coaching occurred via multiple formats and often addressed behavior management and social emotional development regardless of the coaching initiative. Coaches identified challenges regarding scheduling and working with difficult learners and reported that peer support and being coached themselves were the most beneficial learning experiences. Findings suggest that the perspective of the coach is important in informing training and professional learning for both coaches and educators

What Is the Landscape of Early Childhood Coaching in Nebraska?

Background on Early Childhood Coaching in Nebraska Coaches have become an integral component of supporting teachers and adults working with young children and families nationally (Schachter, 2015). In the state of Nebraska, early childhood (EC) coaching has increasingly become important for this type of work (Jayaraman, Knoche, Marvin, & Bainter, 2014). Indeed, multiple initiatives within the state utilize coaches as a mechanism for supporting change in adult learners that leads to positive outcomes for young children and families. In general, coaching is a unique form of professional development that is relationship-based, whereby coaches work one-on-one or in small groups with adult learners to improve knowledge, skills, and dispositions (Aikens & Akers, 2011). Coaching can take place in adults’ immediate context and tends to be ongoing rather than a single, one-time training (Joyce & Showers, 1980; Rush & Shelden, 2005). As such, coaching has the potential to provide high-quality learning experiences for adults to support high-quality experiences in EC. Based on this growing use of coaching across the state, key stakeholders have collaborated to develop mechanisms that support coach training and development. Since this collaborative work began in 2009–10, a semiannual coach training was developed to provide foundational coaching skills and competencies relevant for all coaching initiatives, such as developing relationships and facilitating coaching conversations. The collaborative group also came to understand that coaches needed ongoing support and initiated the offering of regular “booster” sessions to support coaches’ professional development once they are in the field and actively serving coachees. In efforts to better understand who was coaching and perceptions of the training coaches received, stakeholders conducted an initial survey in 2014 (Jayaraman et al. 2014). Results of this survey (n = 35) revealed that coaches liked the work of coaching and, in particular, coaches commented that they enjoyed building relationships with coachees and observing positive changes. Although these coaches were generally positive about the training they received, myriad challenges were also reported, particularly with regards to the coaching process and their own training and professional development needs. Present Study Since the 2014 study, coaching in various EC initiatives has grown across the state. In 2018, the Nebraska Early Childhood Coach Collaboration team was interested in reassessing the process of coaching in Nebraska. This included understanding who is doing the work of coaching, what constitutes the coaching process, how coaches perceive their work, and how coaches were prepared to do their work. Thus, a new survey was created to understand more about coaching in the state of Nebraska. It contained a variety of questions consisting of both fixed-choice and open-response comments. Data collection was led by Dr. Schachter from the University of Nebraska–Lincoln and was reviewed by the Institutional Review Board. Participants were invited by email to complete an online survey that took approximately 20 minutes to complete. The survey was emailed to key stakeholders in the Spring of 2018 with requests that the survey be forwarded to anyone doing the work of EC coaching in Nebraska. In total, 101 individuals completed the survey. Importantly, all participants self-identified as a “coach.” Participants were able to enter into a raffle to win one of five iPad minis. Survey responses were analyzed descriptively. Next, we present our findings regarding who are the coaches, what is the content of coaching, how coaches perceive their work, how coaches know that coaching is working, and how coaches were prepared. We conclude with recommendations for advancing the work of coaching in the state of Nebraska

Development of a parent version of the Manchester-Minneapolis quality of life survey for use by parents and carers of UK children: MMQL-UK (PF)

Background: Although it is now widely endorsed that children should as far as possible rate their own health related quality of life (HRQL), there are situations where proxy information on child HRQL may be useful, especially where a child is too ill or young to provide their own HRQL assessment. There is limited availability of generic HRQL scales that have a parallel child and parent version and that are reliable, valid, brief, comprehensible and suitable for use in UK populations. The aims of this study were therefore to develop and validate a parent version of the anglicised Manchester-Minneapolis Quality of Life child form (MMQL-UK (CF)) and to determine the level of association between the child and parent versions of this form. Methods: This study was undertaken concurrently with the anglicisation and validation of the MMQL, a measure of HRQL developed for use with children in North America. At that time, no parent version existed, so the MMQL form for children (MMQL-UK (CF)) was used as the basis for the development of the MMQL-UK parent form (PF). The sample included a control group of healthy children and their parents and five exemplar groups; children diagnosed with asthma, diabetes or inflammatory bowel disease and their parents, children in remission from cancer and their parents and children in public care and their carers. Consistency of the MMQL-UK (PF) components were assessed by calculating Cronbach's alpha. Validation of the parent questionnaire was undertaken by comparing MMQL-UK (PF) component scores with comparable components on the proxy PedsQL™ quality of life scales, comparing MMQL-UK (PF) component scores between parents of healthy and chronic disease children and by comparison of component scores from children and their parents or carers. Reproducibility and responsiveness were assessed by retesting parents by follow-up questionnaires. Results: A total of 874 children (completing MMQL-UK (CF)) and 572 parents or carers (completing MMQL-UK (PF)) took part in the study. The internal consistency of all the MMQL-UK (PF) components exceeding the accepted criterion of 0.70 and the construct validity was good with moderate correlations being evident between comparable components of the MMQL-UK (PF) and the proxy PedsQL™. Discriminant validity was demonstrated with significant differences being identified between parents of healthy children and those with chronic conditions. Intra-class correlations exceeded 0.65 for all MMQL-UK (PF) components demonstrating good reproducibility. Weak to moderate levels of responsiveness were demonstrated for all but social functioning. The MMQL-UK (PF) showed moderate parent-child correlation with the MMQL-UK (CF) for all components. The best correlations were seen for those components measuring the same construct (Pearson's r ranged from 0.31 to 0.61, p < 0.01 for equivalent components). Conclusion: The MMQL-UK (PF) showed moderate to good correlations with the MMQL-UK (CF) component scores. The MMQL-UK (PF) will be of use when comparing child and parent/carer perception of the impact of a child's condition on their HRQL or where the child is too ill or young to provide their own report

Development and external validation of a clinical prediction model to aid coeliac disease diagnosis in primary care:an observational study

BACKGROUND: Coeliac disease (CD) affects approximately 1% of the population, although only a fraction of patients are diagnosed. Our objective was to develop diagnostic prediction models to help decide who should be offered testing for CD in primary care. METHODS: Logistic regression models were developed in Clinical Practice Research Datalink (CPRD) GOLD (between Sep 9, 1987 and Apr 4, 2021, n=107,075) and externally validated in CPRD Aurum (between Jan 1, 1995 and Jan 15, 2021, n=227,915), two UK primary care databases, using (and controlling for) 1:4 nested case-control designs. Candidate predictors included symptoms and chronic conditions identified in current guidelines and using a systematic review of the literature. We used elastic-net regression to further refine the models. FINDINGS: The prediction model included 24, 24, and 21 predictors for children, women, and men, respectively. For children, the strongest predictors were type 1 diabetes, Turner syndrome, IgA deficiency, or first-degree relatives with CD. For women and men, these were anaemia and first-degree relatives. In the development dataset, the models showed good discrimination with a c-statistic of 0·84 (95% CI 0·83–0·84) in children, 0·77 (0·77–0·78) in women, and 0·81 (0·81–0·82) in men. External validation discrimination was lower, potentially because ‘first-degree relative’ was not recorded in the dataset used for validation. Model calibration was poor, tending to overestimate CD risk in all three groups in both datasets. INTERPRETATION: These prediction models could help identify individuals with an increased risk of CD in relatively low prevalence populations such as primary care. Offering a serological test to these patients could increase case finding for CD. However, this involves offering tests to more people than is currently done. Further work is needed in prospective cohorts to refine and confirm the models and assess clinical and cost effectiveness. FUNDING: National Institute for Health Research Health Technology Assessment Programme (grant number NIHR129020

Spatial monitoring of groundwater drawdown and rebound associated with quarry dewatering using automated time-lapse electrical resistivity tomography and distribution guided clustering

Dewatering systems used for mining and quarrying operations often result in highly artificial and complex groundwater conditions, which can be difficult to characterise and monitor using borehole point sampling approaches. Here automated time-lapse electrical resistivity tomography (ALERT) is considered as a means of monitoring subsurface groundwater dynamics associated with changes in the dewatering regime in an operational sand and gravel quarry. We considered two scenarios: the first was unplanned interruption to dewatering due to a pump failure for a period of several days, which involved comparing ALERT monitoring results before and after groundwater rebound; the second involved a planned interruption to pumping over a period of 6 h, for which near-continuous ALERT monitoring of groundwater rebound and drawdown was undertaken. The results of the second test were analysed using distribution guided clustering (DGC) to provide a more quantitative and objective assessment of changes in the subsurface over time. ALERT successfully identified groundwater level changes during both monitoring scenarios. It provided a more useful indication of the rate of water level rise and maximum water levels than piezometer monitoring results. This was due to the piezometers rapidly responding to pressure changes at depth, whilst ALERT/DGC provided information of slower changes associated with the storage and delayed drainage of water within the sediment. By applying DGC we were able to automatically and quantitatively define changes in the resistivity sections, which correlated well with the direct observations of groundwater at site. For ERT monitoring applications that generate numerous time series, the use of DGC could significantly enhance the efficiency of data interpretation, and provide a means of automating groundwater monitoring through assigning alarm thresholds associated with rapid changes in groundwater conditions

Self-reported sleep duration and napping, cardiac risk factors and markers of subclinical vascular disease: cross-sectional study in older men.

STUDYOBJECTIVES: Daytime sleep has been associated with increased risk of cardiovascular disease and heart failure (HF), but the mechanisms remain unclear. We have investigated the association between daytime and night-time sleep patterns and cardiovascular risk markers in older adults including cardiac markers and subclinical markers of atherosclerosis (arterial stiffness and carotid intima-media thickness (CIMT)). METHODS: Cross-sectional study of 1722 surviving men aged 71-92 examined in 2010-2012 across 24 British towns from a prospective study initiated in 1978-1980. Participants completed a questionnaire and were invited for a physical examination. Men with a history of heart attack or HF (n=251) were excluded from the analysis. RESULTS: Self-reported daytime sleep duration was associated with higher fasting glucose and insulin levels (p=0.02 and p=0.01, respectively) even after adjustment for age, body mass index, physical activity and social class. Compared with those with no daytime sleep, men with daytime sleep >1 hour, defined as excessive daytime sleepiness (EDS), had a higher risk of raised N-terminal pro-brain natriuretic peptide of ≥400 pg/mL, the diagnostic threshold for HF (OR (95% CI)=1.88 (1.15 to 3.1)), higher mean troponin, reduced lung function (forced expiratory volume in 1 s) and elevated von Willebrand factor, a marker of endothelial dysfunction. However, EDS was unrelated to CIMT and arterial stiffness. By contrast, night-time sleep was only associated with HbA1c (short or long sleep) and arterial stiffness (short sleep). CONCLUSIONS: Daytime sleep duration of >1 hour may be an early indicator of HF

The impact of energy systems demands on pressure limited CO2 storage in the Bunter Sandstone of the UK Southern North Sea

National techno-economic pathways to reduce carbon emissions are required for the United Kingdom to meet its decarbonisation obligations as mandated by the Paris Agreement. Analysis using energy systems models indicate that carbon capture and storage is a key technology for the UK to achieve its mitigation targets at lowest cost. There is potential to significantly improve upon the representation of the CO2 storage systems used in these models, but sensitivities of a given reservoir system to future development pathways must be evaluated. To investigate this we generate a range of numerical simulations of CO2 injection into the Bunter Sandstone of the UK Southern North Sea, considered to be one of the most important regional aquifers for CO2 storage. The scenarios investigate the sensitivity of CO2 storage to characteristics of regional development including number of injection sites and target rates of CO2 injection. This enables an evaluation of the impact of a range of deployment possibilities reflecting the range of scenarios that may be explored in an energy system analysis. The results show that limitations in achieving target injection rates are encountered at rates greater than 2 MtCO2/year-site due to local pressure buildup. The areal location of injection sites has minimal impact on the results because the Bunter Sandstone model has good regional connectivity. Rather, the depth of the site is the most important factor controlling limits on CO2 injection due to the relationship between the limiting pressure and the lithostatic pressure gradient. The potential for model simplification is explored by comparison of reservoir simulation with analytical models of average reservoir pressure and near-site pressure. The numerical simulations match average pressure buildup estimated with the “closed-box” analytical model of Zhou et al. (2008) over a 50 year injection period. The pressure buildup at individual sites is estimated using the Mathias et al. (2011) formulation and compared to the simulation response. Discrepancies in the match are mostly due to the interaction of signals from multiple injection sites and heterogeneous permeability in the numerical simulations. These issues should be the focus of further development of simplified models for CO2 storage in an energy systems analysis framework