724 research outputs found
Uplift Quadratic Program in Irish Electricity Price Setting
Bord Gis required a deeper insight into the dynamics of Uplift prices. The aim of the group was to apply a variety of analytical tools to the problem in order to satisfy Bord Gis requirements. The group conducted a KKT Optimality Analysis of the quadratic program used to determine the Uplift prices, performed statistical analysis to identify the binding constraints and their sensitives to the Uplift prices, simulated a synthetic stochastic process that is consistent with the Uplift pricing series and investigated alternative objective functions for the quadratic program
The relation between locus transferrin and the breeding quality traits of country cattle race: lowland Blak-White and Lowland Red-White
International audienc
Draft Genome Sequence of Staphylococcus epidermidis UMB7543, Isolated from a Female Patient with Recurrent Urinary Tract Infections
Staphylococcus epidermidis is a Gram-positive bacterium that is part of the normal human flora, found in multiple anatomical sites. Here, we present the 2.6-Mbp draft genome sequence of S. epidermidis UMB7543, isolated from a catheterized urine sample from a female patient with a documented diagnosis of recurrent urinary tract infection
Comparative Genomic Study of Streptococcus anginosus Reveals Distinct Group of Urinary Strains
Streptococcus anginosus is a prevalent member of the human flora. While it has been found in the microbiota of healthy asymptomatic individuals, it has also been associated with genitourinary tract infections and bacteremia. Based upon multilocus sequence analysis, two subspecies and two genomosubspecies have been characterized for the species. We previously conducted whole-genome sequencing of 85 S. anginosus isolates from the urinary tract. Here, we present genomic analysis of this species, including isolates from the urinary tract as well as gut and fecal, vaginal, oral, respiratory, and blood and heart samples. Average nucleotide identity and core genome analysis revealed that these strains form two distinct groups. Group 1 is comprised of the S. anginosus type strain and other previously identified S. anginosus subspecies and genomosubspecies, including isolates from throughout the human body. In contrast, group 2 consists of predominantly urinary streptococci (n = 77; 85.6%). Both of these S. anginosus groups are distinct from other members of the Streptococcus anginosus group (SAG) species S. intermedius and S. constellatus. Genes conserved among all strains of one group but not in any strains in the other group were next identified. Group 1 strains included genes found in S. intermedius and S. constellatus, suggesting that they were lost within the ancestor of the group 2 strains. In contrast, genes unique to the group 2 strains were homologous to more distant streptococci, indicative of acquisition via horizontal gene transfer. These genes are ideal candidates for use as marker genes to distinguish between the two groups in the human microbiota. IMPORTANCE Whole-genome analysis of S. anginosus strains provides greater insight into the diversity of this species than from marker genes alone. Our investigation of 166 publicly available S. anginosus genomes via average nucleotide identity and core genome analysis revealed two phylogenomically distinct groups of this species, with one group almost exclusively consisting of isolates from the urinary tract. In contrast, only 8 urinary strains were identified within the other group, which contained the S. anginosus type strain, as well as all identified subspecies and genomosubspecies. While genomic analysis suggested that this urinary group of S. anginosus is genomically different from the previously characterized S. anginosus subspecies, phenotypic characterization is still needed. Given prior reports of the prevalence of S. anginosus in the urinary tract of both continent and incontinent females, future studies are needed to investigate if the symptom state of the urinary tract is associated with these two different groups
SEPP1 (selenoprotein P, plasma, 1)
Review on SEPP1 (selenoprotein P, plasma, 1), with data on DNA, on the protein encoded, and where the gene is implicated
Systematic classification of the His-Me finger superfamily
The His-Me finger endonucleases, also known as
HNH or -metal endonucleases, form a large and
diverse protein superfamily. The His-Me finger domain
can be found in proteins that play an essential
role in cells, including genome maintenance, intron
homing, host defense and target offense. Its overall
structural compactness and non-specificity make
it a perfectly-tailored pathogenic module that participates
on both sides of inter- and intra-organismal
competition. An extremely low sequence similarity
across the superfamily makes it difficult to identify
and classify new His-Me fingers. Using state-of-theart
distant homology detection methods, we provide
an updated and systematic classification of His-Me
finger proteins. In this work, we identified over 100
000 proteins and clustered them into 38 groups, of
which three groups are new and cannot be found in
any existing public domain database of protein families.
Based on an analysis of sequences, structures,
domain architectures, and genomic contexts, we provide
a careful functional annotation of the poorly
characterized members of this superfamily. Our results
may inspire further experimental investigations
that should address the predicted activity and clarify
the potential substrates, to provide more detailed insights
into the fundamental biological roles of these
proteins
SEP15 (15 kDa selenoprotein)
Review on SEP15 (15 kDa selenoprotein), with data on DNA, on the protein encoded, and where the gene is implicated
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