1,580 research outputs found
Smoking as an early risk factor for problematic parenting practices
Parenting among those who use non-illicit and more common drugs such as cigarettes remains an understudied area for investigation. Secondary data analyses were performed in 2015 on a prospective study with parent and twin data available on n=3,009 individual members of female twin pairs born between July 1975 and June 1985 identified from Missouri-state birth records. Maternal smoking when the twins were 3+ years of age remained a significant predictor of offspring report of childhood sexual abuse (OR, 1.40; 95% CI, 1.02-1.92) after controlling for key covariates. Given limited public health resources, mothers who smoke during child's preschool years may be targeted for tailored parenting intervention
Familial influences on the full range of variability in attention and activity levels during adolescence: A longitudinal twin study
AbstractTo investigate familial influences on the full range of variability in attention and activity across adolescence, we collected maternal ratings of 339 twin pairs at ages 12, 14, and 16, and estimated the transmitted and new familial influences on attention and activity as measured by the Strengths and Weaknesses of Attention-Deficit/Hyperactivity Disorder Symptoms and Normal Behavior Scale. Familial influences were substantial for both traits across adolescence: genetic influences accounted for 54%–73% (attention) and 31%–73% (activity) of the total variance, and shared environmental influences accounted for 0%–22% of the attention variance and 13%–57% of the activity variance. The longitudinal stability of individual differences in attention and activity was largely accounted for by familial influences transmitted from previous ages. Innovations over adolescence were also partially attributable to familial influences. Studying the full range of variability in attention and activity may facilitate our understanding of attention-deficit/hyperactivity disorder's etiology and intervention.</jats:p
Associations among adolescent conduct problems and perceived peer and parental acceptance of adolescent alcohol use
Do genetic influences on abuse and dependence overlap? Explorations using cannabis and alcohol diagnoses
Ataxia Telangiectasia Mutated Dysregulation Results in Diabetic Retinopathy
Ataxia telangiectasia mutated (ATM) acts as a defense against a variety of bone marrow (BM) stressors. We hypothesized that ATM loss in BM-hematopoietic stem cells (HSCs) would be detrimental to both HSC function and microvascular repair while sustained ATM would be beneficial in disease models of diabetes. Chronic diabetes represents a condition associated with HSC depletion and inadequate vascular repair. Gender mismatched chimeras of ATM(-/-) on wild type background were generated and a cohort were made diabetic using streptozotocin (STZ). HSCs from the STZ-ATM(-/-) chimeras showed (a) reduced self-renewal; (b) decreased long-term repopulation; (c) depletion from the primitive endosteal niche; (d) myeloid bias; and (e) accelerated diabetic retinopathy (DR). To further test the significance of ATM in hematopoiesis and diabetes, we performed microarrays on circulating angiogenic cells, CD34(+) cells, obtained from a unique cohort of human subjects with long-standing (>40 years duration) poorly controlled diabetes that were free of DR. Pathway analysis of microarrays in these individuals revealed DNA repair and cell-cycle regulation as the top networks with marked upregulation of ATM mRNA compared with CD34(+) cells from diabetics with DR. In conclusion, our study highlights using rodent models and human subjects, the critical role of ATM in microvascular repair in DR
Finding the mechanism of wave energy flux damping in solar pores using numerical simulations
Context. Solar magnetic pores are, due to their concentrated magnetic fields,
suitable guides for magnetoacoustic waves. Recent observations have shown that
propagating energy flux in pores is subject to strong damping with height;
however, the reason is still unclear. Aims. We investigate possible damping
mechanisms numerically to explain the observations. Methods. We performed 2D
numerical magnetohydrodynamic (MHD) simulations, starting from an equilibrium
model of a single pore inspired by the observed properties. Energy was inserted
into the bottom of the domain via different vertical drivers with a period of
30s. Simulations were performed with both ideal MHD and non-ideal effects.
Results. While the analysis of the energy flux for ideal and non-ideal MHD
simulations with a plane driver cannot reproduce the observed damping, the
numerically predicted damping for a localized driver closely corresponds with
the observations. The strong damping in simulations with localized driver was
caused by two geometric effects, geometric spreading due to diverging field
lines and lateral wave leakage.Comment: 12 pages (including appendix), 13 figures, accepted for publication
by A&
Upstream sequence elements direct post-transcriptional regulation of gene expression under stress conditions in yeast
The magnitude of genetic and environmental influences common to comorbid alcoholism and marijuana problem use is stable across diagnostic phenotypes
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