578 research outputs found
A very faint core-collapse supernova in M85
An anomalous transient in the early Hubble-type (S0) galaxy Messier 85 (M85)
in the Virgo cluster was discovered by Kulkarni et al. (2007) on 7 January 2006
that had very low luminosity (peak absolute R-band magnitude MR of about -12)
that was constant over more than 80 days, red colour and narrow spectral lines,
which seem inconsistent with those observed in any known class of transient
events. Kulkarni et al. (2007) suggest an exotic stellar merger as the possible
origin. An alternative explanation is that the transient in M85 was a type
II-plateau supernova of extremely low luminosity, exploding in a lenticular
galaxy with residual star-forming activity. This intriguing transient might be
the faintest supernova that has ever been discovered.Comment: 7 pages, 2 figures. Submitted to Nature "Brief Communication Arising"
on 18 July 2007, Accepted on 17 August 2007. Arising from: Kulkarni et al.
2007, Nature, 447, 458-46
Gene Function Classification Using Bayesian Models with Hierarchy-Based Priors
We investigate the application of hierarchical classification schemes to the
annotation of gene function based on several characteristics of protein
sequences including phylogenic descriptors, sequence based attributes, and
predicted secondary structure. We discuss three Bayesian models and compare
their performance in terms of predictive accuracy. These models are the
ordinary multinomial logit (MNL) model, a hierarchical model based on a set of
nested MNL models, and a MNL model with a prior that introduces correlations
between the parameters for classes that are nearby in the hierarchy. We also
provide a new scheme for combining different sources of information. We use
these models to predict the functional class of Open Reading Frames (ORFs) from
the E. coli genome. The results from all three models show substantial
improvement over previous methods, which were based on the C5 algorithm. The
MNL model using a prior based on the hierarchy outperforms both the
non-hierarchical MNL model and the nested MNL model. In contrast to previous
attempts at combining these sources of information, our approach results in a
higher accuracy rate when compared to models that use each data source alone.
Together, these results show that gene function can be predicted with higher
accuracy than previously achieved, using Bayesian models that incorporate
suitable prior information
Progress in Understanding and Treating SCN2A-Mediated Disorders
Advances in gene discovery for neurodevelopmental disorders have identified SCN2A dysfunction as a leading cause of infantile seizures, autism spectrum disorder, and intellectual disability. SCN2A encodes the neuronal sodium channel NaV1.2. Functional assays demonstrate strong correlation between genotype and phenotype. This insight can help guide therapeutic decisions and raises the possibility that ligands that selectively enhance or diminish channel function may improve symptoms. The well-defined function of sodium channels makes SCN2A an important test case for investigating the neurobiology of neurodevelopmental disorders more generally. Here, we discuss the progress made, through the concerted efforts of a diverse group of academic and industry scientists as well as policy advocates, in understanding and treating SCN2A-related disorders
International Trade Under the Rule of Law Conference
The central focus of the conference was the dispute settlement system of the World Trade Organization (WTO), with a view toward exploring the need for a superstructure of international law governing trade and economic cooperation between countries
No. 5 - International Trade under the Rule of Law: An American Society of International Law Centennial Regional Meeting
Organized and sponsored by the Dean Rusk Center and designated an American Society of International Law Centennial Regional Meeting, this conference focused on the Dispute Settlement System (DSS) of the World Trade Organization (WTO) with a view toward discussing the need for a superstructure of international law governing trade and economic cooperation between states
An Update on Grading of Salivary Gland Carcinomas
Histologic grade is a significant predictor of outcome in salivary gland carcinomas. However, the sheer variety of tumor type and the rarity of these tumors pose challenges to devising highly predictive grading schemes. As our knowledge base has evolved, it is clear that carcinoma ex pleomorphic adenoma is not automatically a high grade tumor as is traditionally suggested. These tumors should be further qualified as to type/grade of carcinoma and extent, since intracapsular and minimally invasive carcinomas ex pleomorphic adenoma behave favorably. The two carcinoma types for which grading schemes are common include adenoid cystic carcinoma and mucoepidermoid carcinoma. Adenoid cystic carcinomas are graded based solely on pattern with solid components portending a worse prognosis. Occasionally, adenoid cystic carcinomas may undergo transformation to pleomorphic high grade carcinomas. This feature confers a high propensity for lymph node metastasis and should thus be reported to alert the clinical team. Mucoepidermoid carcinomas are graded in a three tier fashion based on a constellation of features including cystic component, border, mitoses, anaplasia, and perineural invasion among others. All grading schemes are somewhat cumbersome, intimidating and occasionally ambiguous, but evidence suggests that using a scheme consistently shows greater reproducibility than using an intuitive approach. The intermediate grade category demonstrates the most variability between grading systems and thus the most controversy in management. In the AFIP system intermediate grade tumors cluster with high grade tumors, while in the Brandwein system, they cluster with low grade tumors
Can three-flavor oscillations solve the solar neutrino problem?
The most promising solution to the solar neutrino problem are neutrino
oscillations, which usually are analyzed within the reduced 2-flavor scheme,
because the solutions found therein reasonably well reproduce the recent data
of Super-Kamiokande about the recoil-electron energy spectrum, zenith-angle and
seasonal variations, and the event rate data of all the neutrino detectors. In
this work, however, a survey of the complete parameter space of 3-flavor
oscillations is performed. Basically eight new additional solutions could be
identified, where the best one with \Delta m(12)^2=2.7x10^(-10) eV^2, \Delta
m(13)^2=1.0x10^(-5) eV^2, \Theta(12)=23, and \Theta(13)=1.3 (denoted SVO) is
slightly more probable than any 2-flavor solution. However, including the
results of the atmospheric neutrino problem excludes all 3-flavour solutions
apart from the SLMA-solution (\Delta m(12)^2=7.9x10^(-6) eV^2, \Delta
m(13)^2=2.5x10^(-4) eV^2, \Theta(12)=1.4, and \Theta(13)=20). Besides, the
ability of SNO and Borexino to discriminate the various 2- and 3-flavor
solutions is investigated. Only with very good statistics in these experiments
the correct solution to the solar neutrino problem can be identified
unambiguously.Comment: 22 pages, 19 figures, REVTeX, submitted to Phys.Rev.D, article with
better resolved figures available under
http://www.mpa-garching.mpg.de/~schlattl/public.htm
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