Enhancement of Soybean Meal Alters Gut Microbiome and Influences Behavior of Farmed Atlantic Salmon (Salmo salar)

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Feeding black soldier fly larvae (Hermetia illucens) reared on organic rest streams alters gut characteristics of Atlantic salmon (Salmo salar)

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Panorama atual e potencial de aplicação da abordagem dos serviços ecossistêmicos do solo no Brasil

Human pressure on ecosystems has undesirable impacts on human well-being. After the Millennium Project, much interdisciplinary research has been developed worldwide aiming to understand these impacts on ecosystem flows and processes, and to learn about the costs and the benefits of ecosystem services for production. Soil provides many ecosystem services, since its multi-functionality is the basis for food production, water filtration, nutrient cycling, and other goods essential to life. This article presents the main concepts and classifications of soil ecosystem services and of its functions; the indicators and the methods for assessment, modeling, and valuation of ecosystem services; some recent applications to assess and evaluate impacts of agricultural management practices on soil ecosystem services; as well as challenges and opportunities for research and for development of public policies related to agro-environmental sustainability in Brazil. Although the role of soil in supplying ecosystem services is yet undervalued, scientists are gradually recognizing soil processes and functions as fundamental to assess ecosystem services and the effects of land use and management on them. Interdisciplinary approaches to integrate science and public policies are necessary to build governance based on ecosystem services.A pressão humana sobre os serviços ecossistêmicos tem resultado em impactos indesejáveis sobre o bem-estar humano. Com o Projeto Millennium, várias pesquisas interdisciplinares têm sido desenvolvidas em todo o mundo com o objetivo de entender esses impactos sobre os fluxos e os processos dos ecossistemas e internalizar os custos e os benefícios dos serviços ecossistêmicos para a produção. O solo fornece muitos serviços ecossistêmicos, uma vez que sua multifuncionalidade é a base para a produção de alimentos, filtração de água, ciclagem de nutrientes e outros bens essenciais à vida. Este artigo apresenta os principais conceitos e classificações dos serviços ecossistêmicos do solo e de suas funções; os indicadores e os métodos de avaliação, modelagem e valoração dos serviços ecossistêmicos; algumas aplicações recentes para avaliar impactos de práticas de manejo agrícola sobre os serviços ecossistêmicos do solo; bem como os desafios e as oportunidades para a pesquisa e para o desenvolvimento de políticas públicas relacionadas à sustentabilidade agroambiental no Brasil. Apesar de o papel do solo para prestação de serviços ecossistêmicos ainda ser subestimado, os cientistas têm gradualmente reconhecido os processos e as funções do solo como fundamentais para avaliar os serviços ecossistêmicos e os efeitos do uso e manejo da terra sobre eles. Abordagens interdisciplinares que integrem ciência e políticas públicas são necessárias para construir uma governança com base em serviços ecossistêmicos

Envejecimiento de la población

•Actividades básicas de la vida diaria en personas mayores y factores asociados •Asociación entre depresión y posesión de mascotas en personas mayores •Calidad de vida en adultos mayores de Santiago aplicando el instrumento WHOQOL-BREF •Calidad de vida en usuarios con enfermedad de Parkinson, demencia y sus cuidadores, comuna de Vitacura •Caracterización de egresos hospitalarios de adultos mayores en Puerto Natales (2007-2009) •Comportamiento de las patologías incluidas como GES para el adulto mayor atendido en un Cesfam •Contribución de vitaminas y minerales a las ingestas recomendadas diarias en ancianos institucionalizados de Madrid •Estado de salud oral del paciente inscrito en el Programa de Visita Domiciliaria •Evaluación del programa de discapacidad severa en Casablanca con la matriz de marco lógico •Factores asociados a satisfacción vital en una cohorte de adultos mayores de Santiago, Chile •Pauta instrumental para la identificación de riesgos para el adulto mayor autovalente, en su vivienda •Perfil farmacológico del paciente geriátrico institucionalizado y posibles consecuencias en el deterioro cognitivo •Programa de cuidados paliativos y alivio del dolor en Puerto Natales •Rehabilitación mandibular implantoprotésica: efecto en calidad de vida relacionada con salud bucal en adultos mayores •Salud bucodental en adultos mayores autovalentes de la Región de Valparaíso •Transición epidemiológica y el estudio de carga de enfermedad en Brasi

Hukum perdata 1 : buku panduan mahasiswa

Bibl. : 199 - 200xi, 200 hlm. ; 23 cm

Hukum perdata I: Buku panduan mahasiswa

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Hukum perdata: Buku panduan mahasiswa

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Enhancement Of Chlorpromazine Antitumor Activity By Pluronics F127/l81 Nanostructured System Against Human Multidrug Resistant Leukemia

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)The development of specific tyrosine kinase inhibitors (TKIs) revolutionized the treatment of chronic myeloid leukemia (CML). However, chemoresistance of tumor cells to TKIs has already been described, and several mechanisms account for the multidrug resistance (MDR) phenotypes, including the over expression of P-glycoprotein (P-gp). This decreases the rate of healing and complete tumor remission. Nanotechnological tools have been studied to allow advances in this field. Poloxamers (Pluronics) have been proposed as drug carriers to improve therapeutic efficacy and decrease side effects, even in cancer therapy, due to their ability to inhibit P-gp. Antipsychotic phenothiazines have been described as potent cytotoxic drugs against several types of tumor cells in vitro. Here, we show that nanostructured micellar systems containing the phenothiazine derivative chlorpromazine (CPZ) potentiated the cytotoxicity of free CPZ and increased the selectivity against CML tumor cells, demonstrating the pharmacological potential of these poloxamer-based nanostructured systems containing CPZ in cancer therapy. (C) 2016 Elsevier Ltd. All rights reserved.111102112Brazilian agency FAPESP [2011/21433-7, 2012/12247-8, 2013/05099-5]Brazilian agency CNPq [301239/2012-6]Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq

Algoritmo para a composição de dados por internação a partir do sistema de informações hospitalares do sistema único de saúde (SIH/SUS) - Composição de dados por internação a partir do SIH/SUS

A autorização de internação hospitalar (AIH), unidade de observação do Sistema de Informações Hospitalares do SUS (SIH/SUS), pode corresponder a uma internação de caráter agudo ou a um período delimitado de uma internação de longa duração. Este trabalho apresenta um algoritmo para a composição de dados por internação a partir das AIHs, possibilitando a consideração adequada da mortalidade hospitalar, custos sob a perspectiva do SUS e tempo de permanência hospitalar em internações de longa permanência, típicas, em especial, entre pacientes crônicos/fora de possibilidade terapêutica e psiquiátricos

Vkorc1 V66m Mutation In African Brazilian Patients Resistant To Oral Anticoagulant Therapy.

Warfarin-based anticoagulant therapy is associated with large variability in dose response. Genetic variability in the VKORC1 and CYP2C9 genes is associated with increased warfarin sensitivity. In addition, rare coding region mutations in VKORC1 have been associated with resistance to warfarin. VKORC1 and CYP2C9 variability associated with altered warfarin response is less well characterized in African and mixed-raced populations such as Brazilians. To determine genetic variability associated with altered warfarin response among Brazilian patients, sixty-two adult patients with extreme resistance or sensitivity to warfarin were genotyped for variants in CYP2C9 and VKORC1. Of the 51 patients on low doses of warfarin, the VKORC1--1639 (3673) G>A polymorphism associated with warfarin sensitivity was present in 48 (94.1%), including 97% of Caucasians, 82% of African-descent patients, and all 7 (100%) patients of Indian descent. Additionally, 52.9% of warfarin sensitive patients had at least one CYP2C9*2 or CYP2C9*3 decreased metabolism allele, 63.6% of Caucasians and 54% of African-descent patients. Of the 11 patients on high doses of warfarin, sequencing of VKORC1 revealed a nonsynonymous V66M mutation in two warfarin resistant patients, both of African-descent. Brazilian patients requiring low doses of warfarin have a high frequency of VKORC1 and CYP2C9 variants associated with warfarin sensitivity. The presence of the rare VKORC1 V66M in two warfarin high dose outlier patients implies that this variant may be more frequent among African Brazilians and has implications for future warfarin studies in other populations of African descent.126e206-1