Uso de benzodiacepinas por adictos a heroína a propósito de una revisión bibliográfica.

En este trabajo se aborda una revisión bibliográfica sobre la relación existente entre la dependencia a la heroína y el uso, abuso y dependencia a las benzodiacepinas (BZD). Se señala la amplia extensión del consumo de BZD por adictos en general y por los dependientes a heroína en particular, así como la posible naturaleza de tal consumo por este tipo de adictos. En nuestro medio las moléculas de BZD de las que más abusan los pacientes heroinómanos tratados son cloracepato dipotásico y flunitrazepam. Se analizan las posibles causas de esta preferencia en función de los resultados de los estudios revisados. Igualmente se señala la posible existencia de un patrón de uso y abuso particular para este tipo de adicto

Uso de benzodiacepinas por adictos a heroína a propósito de una revisión bibliográfica.

En este trabajo se aborda una revisión bibliográfica sobre la relación existente entre la dependencia a la heroína y el uso, abuso y dependencia a las benzodiacepinas (BZD). Se señala la amplia extensión del consumo de BZD por adictos en general y por los dependientes a heroína en particular, así como la posible naturaleza de tal consumo por este tipo de adictos. En nuestro medio las moléculas de BZD de las que más abusan los pacientes heroinómanos tratados son cloracepato dipotásico y flunitrazepam. Se analizan las posibles causas de esta preferencia en función de los resultados de los estudios revisados. Igualmente se señala la posible existencia de un patrón de uso y abuso particular para este tipo de adicto

Uso de benzodiacepinas por adictos a heroína a propósito de una revisión bibliográfica.

En este trabajo se aborda una revisión bibliográfica sobre la relación existente entre la dependencia a la heroína y el uso, abuso y dependencia a las benzodiacepinas (BZD). Se señala la amplia extensión del consumo de BZD por adictos en general y por los dependientes a heroína en particular, así como la posible naturaleza de tal consumo por este tipo de adictos. En nuestro medio las moléculas de BZD de las que más abusan los pacientes heroinómanos tratados son cloracepato dipotásico y flunitrazepam. Se analizan las posibles causas de esta preferencia en función de los resultados de los estudios revisados. Igualmente se señala la posible existencia de un patrón de uso y abuso particular para este tipo de adicto

Miositis viral con rabdomiólisis secundaria: un caso confirmado y revisión de la literatura

Rhabdomyolysis is a severe syndrome that can produce acute renal failure and even death. Causative mechanisms of rhabdomyolysis include various viruses, among which are the Coxsackie viruses. We report the case of a 36-year-old woman who had rhabdomyolysis due to Coxsackie A9 virus, with severe muscle involvement, though with no important kidney damage. She recovered with intravenous hydration and alkalinization of the urine.La rabdomiólisis es un síndrome grave que puede producir insuficiencia renal aguda e incluso la muerte. Los mecanismos causantes de rabdomiólisis incluyen varios virus, entre los que se encuentran los virus Coxsackie. Presentamos el caso de una mujer de 36 años de edad que tenía rabdomiólisis debido a Coxsackie A9, con afectación muscular grave, aunque sin daño renal importante. Se recuperó con la hidratación intravenosa y la alcalinización de la orina

Tensor product representation of Kothe-Bochner spaces and their dual spaces

We provide a tensor product representation of Kothe-Bochner function spaces of vector valued integrable functions. As an application, we show that the dual space of a Kothe-Bochner function space can be understood as a space of operators satisfying a certain extension property. We apply our results in order to give an alternate representation of the dual of the Bochner spaces of p-integrable functions and to analyze some properties of the natural norms that are defined on the associated tensor products.First and third authors are supported by grant MTM201453009-P of the Ministerio de Economia y Competitividad (Spain). Second and fourth authors are supported by grant MTM2012-36740-C02-02 of the Ministerio de Economia y Competitividad (Spain).Calabuig, JM.; Jiménez Fernández, E.; Juan Blanco, MA.; Sánchez Pérez, EA. (2016). Tensor product representation of Kothe-Bochner spaces and their dual spaces. Positivity. 20(1):155-169. https://doi.org/10.1007/s11117-015-0347-3S155169201Bochner, S.: Integration von Funktionen, deren Werte die Elemente eines Vectorraumes sind. Fundamenta Mathematicae 20, 262–276 (1933)Calabuig, J.M., Delgado, O., Juan, M.A., Sánchez, E.A.: Pérez, On the Banach lattice structure of $$L^1_w$$ L w 1 of a vector measure on a $$\delta$$ δ -ring. Collect. Math. 65, 6567–85 (2014)Calabuig, J.M., Delgado, O., Sánchez Pérez, E.A.: Factorizing operators on Banach function spaces through spaces of multiplication operators. J. Math. Anal. Appl. 364(1), 88–103 (2010)Calabuig, J.M., Gregori, P., Sánchez, E.A.: Pérez, Radon-Nikodým derivatives for vector measures belonging to Köthe function spaces. J. Math. Anal. Appl. 348, 469–479 (2008)Cerdà, J., Hudzik, H., Mastyło, M.: Geometric properties of Köthe-Bochner spaces. Math. Proc. Cambridge Philos. Soc. 120(3), 521–533 (1996)Chakraborty, N.D., Basu, S.: Spaces of p-tensor integrable functions and related Banach space properties. Real Anal. Exchange 34, 87–104 (2008)Chakraborty, N.D., Basu, S.: Integration of vector-valued functions with respect to vector measures defined on $$\delta$$ δ -rings. Ill. J. Math. 55(2), 495–508 (2011)Defant, A., Floret, K.: Tensor norms and operator ideals. North-Holland, Amsterdam (1993)Delgado, O., Juan, M.A.: Representation of Banach lattices as $$L^{1}_{w}$$ L w 1 spaces of a vector measure defined on a $$\delta -$$ δ - ring. Bull. Belgian Math. Soc. 19, 239–256 (2012)Diestel, J., Uhl, J.J.: Vector measures. Am. Math. Soc, Providence (1977)Dobrakov, I.: On integration in Banach spaces, VII. Czechoslovak Math. J. 38, 434–449 (1988)García-Raffi, L.M., Jefferies, B.: An application of bilinear integration to quantum scattering. J. Math. Anal. Appl. 415, 394–421 (2014)Gregori Huerta, P.: Espacios de medidas vectoriales. Thesis, Universidad de Valencia, ISBN:8437060591 (2005)Jefferies, B., Okada, S.: Bilinear integration in tensor products. Rocky Mt. J. Math. 28, 517–545 (1998)Lewis, D.R.: On integrability and summability in vector spaces. Ill. J. Math. 16, 294–307 (1972)Lin, P.-K.: Köthe-Bochner function spaces. Birkhauser, Boston (2004)Lindenstrauss, J., Tzafriri, L.: Classical Banach spaces II. Springer, Berlin (1979)Okada, S., Ricker, W.J., Sánchez Pérez, E.A.: Optimal Domains and integral extensions of operators acting in function spaces. Operator Theory Advances and Applications, vol. 180. Birkhäuser, Basel (2008)Pallu de La Barriére, R.: Integration of vector functions with respect to vector measures. Studia Univ. Babes-Bolyai Math. 43, 55–93 (1998)Rodríguez, J.: On integration of vector functions with respect to vector measures. Czechoslovak Math. J. 56, 805–825 (2006

Adenosine A2A receptor modulation of hippocampal CA3-CA1 synapse plasticity during associative learning in behaving mice

© 2009 Nature Publishing Group All rights reservedPrevious in vitro studies have characterized the electrophysiological and molecular signaling pathways of adenosine tonic modulation on long-lasting synaptic plasticity events, particularly for hippocampal long-term potentiation(LTP). However, it remains to be elucidated whether the long-term changes produced by endogenous adenosine in the efficiency of synapses are related to those required for learning and memory formation. Our goal was to understand how endogenous activation of adenosine excitatory A2A receptors modulates the associative learning evolution in conscious behaving mice. We have studied here the effects of the application of a highly selective A2A receptor antagonist, SCH58261, upon a well-known associative learning paradigm - classical eyeblink conditioning. We used a trace paradigm, with a tone as the conditioned stimulus (CS) and an electric shock presented to the supraorbital nerve as the unconditioned stimulus(US). A single electrical pulse was presented to the Schaffer collateral–commissural pathway to evoke field EPSPs (fEPSPs) in the pyramidal CA1 area during the CS–US interval. In vehicle-injected animals, there was a progressive increase in the percentage of conditioning responses (CRs) and in the slope of fEPSPs through conditioning sessions, an effect that was completely prevented (and lost) in SCH58261 (0.5 mg/kg, i.p.)-injected animals. Moreover, experimentally evoked LTP was impaired in SCH58261- injected mice. In conclusion, the endogenous activation of adenosine A2A receptors plays a pivotal effect on the associative learning process and its relevant hippocampal circuits, including activity-dependent changes at the CA3-CA1 synapse.This study was supported by grants from the Spanish Ministry of Education and Research (BFU2005-01024 and BFU2005-02512), Spanish Junta de Andalucía (BIO-122 and CVI-02487), and the Fundación Conocimiento y Cultura of the Pablo de Olavide University (Seville, Spain).B. Fontinha was in receipt of a studentship from a project grant (POCI/SAU-NEU/56332/2004) supported by Fundação para a Ciência e Tecnologia (FCT, Portugal), and of an STSM from Cost B30 concerted action of the EU

Motor-Coordination-Dependent Learning, More than Others, Is Impaired in Transgenic Mice Expressing Pseudorabies Virus Immediate-Early Protein IE180

The cerebellum in transgenic mice expressing pseudorabies virus immediate-early protein IE180 (TgIE96) was substantially diminished in size, and its histoarchitecture was severely disorganized, resulting in severe ataxia. TgIE96 mice can therefore be used as an experimental model to study the involvement of cerebellar circuits in different learning tasks. The performance of three-month-old TgIE96 mice was studied in various behavioral tests, including associative learning (classical eyeblink conditioning), object recognition, spatial orientation (water maze), startle response and prepulse inhibition, and passive avoidance, and compared with that of wild-type mice. Wild-type and TgIE96 mice presented similar reflexively evoked eyeblinks, and acquired classical conditioned eyelid responses with similar learning curves for both trace and delay conditioning paradigms. The two groups of mice also had similar performances during the object recognition test. However, they showed significant differences for the other three tests included in this study. Although both groups of animals were capable of swimming, TgIE96 mice failed to learn the water maze task during the allowed time. The startle response to a severe tone was similar in both control and TgIE96 mice, but the latter were unable to produce a significant prepulse inhibition. TgIE96 mice also presented evident deficits for the proper accomplishment of a passive avoidance test. These results suggest that the cerebellum is not indispensable for the performance of classical eyeblink conditioning and for object recognition tasks, but seems to be necessary for the proper performance of water maze, prepulse inhibition, and passive avoidance tests

Problematic Internet Use in University Students: associated factors and differences of gender

El objetivo del presente trabajo es realizar un análisis descriptivo del uso problemático de Internet en estudiantes universitarios, evaluando la posible asociación con problemas de salud y conductas adictivas, así como diferencias de género en los tipos utilización. Un total de 2780 alumnos participaron en el estudio entre los años 2011 – 2014, siendo un 29% varones (edad 20.8 ± 5.1 años) y un 71% mujeres (edad de 20.3 ± 4.4 años). La prevalencia de uso problemático de Internet evaluada mediante el Internet Addiction Test fue del 6.08%. Ser menor de 21 años y cursar titulaciones diferentes a ciencias de la salud fueron factores asociados a una mayor frecuencia de este problema, no existiendo diferencias en función del sexo o tipo de domicilio. Los resultados muestran una asociación significativa con algunos problemas de salud (migrañas, dolor lumbar, sobrepeso u obesidad, descanso insuficiente), aspectos psicológicos (riesgo de trastornos de la conducta alimentaria, riesgo de trastorno mental, depresión), problemas familiares y discriminación; no encontrándose asociaciones con consumo de sustancias adictivas (alcohol, tabaco o cannabis). Respecto al tiempo de uso de Internet, las horas de conexión semanales fueron significativamente mayores en las mujeres que en los hombres, tanto en el tiempo total como por motivos de ocio. El análisis del perfil de utilización en usuarios problemáticos reveló que los varones se relacionan más con aspectos de ocio como los juegos o las compras online y las mujeres con aspectos de socialización, como el chat o las redes sociales

The Neurogenesis Actuator and NR2B/NMDA Receptor Antagonist Ro25-6981 Consistently Improves Spatial Memory Retraining Via Brain Region-Specific Gene Expression

NR2B-containing NMDA (NR2B/NMDA) receptors are important in controlling neurogenesis and are involved in generating spatial memory. Ro25-6981 is a selective antagonist at these receptors and actuates neurogenesis and spatial memory. Inter-structural neuroanatomical profiles of gene expression regulating adult neurogenesis and neuroapoptosis require examination in the context of memory retrieval and reversal learning. The aim was to investigate spatial memory retrieval and reversal learning in relation to gene expression-linked neurogenetic processes following blockade of NR2B/NMDA receptors by Ro25-6981. Rats were trained in Morris water maze (MWM) platform location for 5 days. Ro25-6981 was administered (protocol days 6–7) followed by retraining (days 15–18 or 29–32). Platform location was tested (on days 19 or 33) then post-mortem brain tissue sampling (on days 20 or 34). The expression of three genes known to regulate cell proliferation (S100a6), differentiation (Ascl1), and apoptosis (Casp-3) were concomitantly evaluated in the hippocampus, prefrontal cortex, and cerebellum in relation to the MWM performance protocol. Following initial training, Ro25-6981 enhanced visuospatial memory retrieval performance during further retraining (protocol days 29–32) but did not influence visuospatial reversal learning (day 33). Hippocampal Ascl1 and Casp-3 expressions were correspondingly increased and decreased while cerebellar S100a6 and Casp-3 activities were decreased and increased respectively 27 days after Ro25-6981 treatment. Chronological analysis indicated a possible involvement of new mature neurons in the reconfiguration of memory processes. This was attended by behavioral/gene correlations which revealed direct links between spatial memory retrieval enhancement and modified gene activity induced by NR2B/NMDA receptor blockade and upregulation