4 research outputs found
Influence of Olfactory Epithelium on Mitral/Tufted Cell Dendritic Outgrowth
- Author
- A Blanchart
- A Walz
- A Walz
- AK McAllister
- AK McAllister
- AK McAllister
- Andreas Walz
- CA Byrd
- D Malun
- D Nakajima
- DJ Phillips
- DK Binder
- DM Lin
- F Polleux
- GA Schwarting
- H Kobayashi
- H Treloar
- Ha Tran
- HB Treloar
- HN Beck
- Huaiyang Chen
- I Matsuura
- I Rockle
- J Shou
- Jamie C. Posthumus
- JC Hocking
- JH Cho
- JM Couper Leo
- JW Hinds
- JW Hinds
- JW Hinds
- K Kosaka
- KJ Ressler
- KL Whitford
- KL Whitford
- L Lopez-Mascaraque
- L Lopez-Mascaraque
- Michael Hendricks
- MS Bailey
- P Mombaerts
- P Peretto
- PA Dijkhuizen
- PJ Lein
- PPC Graziadei
- Q Gong
- Qizhi Gong
- R Threadgill
- R Vassar
- RP Stout
- S Esquenazi
- S Matsutani
- T Cutforth
- T Hirata
- T Kaneko-Goto
- T Nakamura
- U Michel
- W Balemans
- W Balemans
- W Lee
- WC Smith
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2008
- Field of study
Stereotypical connections between olfactory sensory neuron axons and mitral cell dendrites in the olfactory bulb establish the first synaptic relay for olfactory perception. While mechanisms of olfactory sensory axon targeting are reported, molecular regulation of mitral cell dendritic growth and refinement are unclear. During embryonic development, mitral cell dendritic distribution overlaps with olfactory sensory axon terminals in the olfactory bulb. In this study, we investigate whether olfactory sensory neurons in the olfactory epithelium influence mitral cell dendritic outgrowth in vitro. We report a soluble trophic activity in the olfactory epithelium conditioned medium which promotes mitral/tufted cell neurite outgrowth. While the trophic activity is present in both embryonic and postnatal olfactory epithelia, only embryonic but not postnatal mitral/tufted cells respond to this activity. We show that BMP2, 5 and 7 promote mitral/tufted cells neurite outgrowth. However, the BMP antagonist, Noggin, fails to neutralize the olfactory epithelium derived neurite growth promoting activity. We provide evidence that olfactory epithelium derived activity is a protein factor with molecular weight between 50–100 kD. We also observed that Follistatin can effectively neutralize the olfactory epithelium derived activity, suggesting that TGF-beta family proteins are involved to promote mitral/tufted dendritic elaboration
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.
- Author
- Abecasis GR
- Abecasis Gonçalo R.
- Absher D
- Adair Linda S.
- Adeyemo Adebowale
- Aherrahrou Z
- Ahmadi KR
- Ala-Korpela Mika
- Alexander Myriam
- Altshuler D
- Altshuler David
- Amin Najaf
- Andersen K
- Aragam J
- Arfan Ikram M.
- Arking DE
- Arking Dan E.
- Arnett D
- Arora Pankaj
- Artigas Maria Soler
- Aspelund T
- Aspelund Thor
- Assimes TL
- Atkinson EJ
- Aulchenko YS
- Aulchenko YS
- Aulchenko YS
- Aulchenko Yurii
- Badola S
- Bakker SJ
- Bakker Stephan J. L.
- Ball SG
- Balmforth AJ
- Bandinelli Stefania
- Barbalic M
- Barroso Inês
- Beckmann J
- Beckmann Jacques S.
- Beilby John P.
- Benjamin E
- Benjamin EJ
- Bergman Richard N.
- Bergmann Sven
- Bickel C
- Bilo HJ
- Bis J
- Bis JC
- Bis JC
- Bis Joshua C.
- Blankenberg S
- Blankenberg S
- Blankenberg S
- Blettner M
- Boban M
- Bochud M
- Bochud Murielle
- Boehnke Michael
- Boerwinkle E
- Boerwinkle E
- Boerwinkle E
- Boerwinkle Eric
- Bolton Judith A Hoffman
- Bonnycastle Lori L.
- Borecki I
- Bornstein Stefan R.
- Bots Michiel L.
- Bragg-Gresham Jennifer L.
- Brand Eva
- Brand Stefan-Martin
- Brandstätter A
- Braund PS
- Braund Peter S.
- Brown MJ
- Brown Morris J.
- Bruse P
- Burnett MS
- Burton Paul R.
- Burtt N
- Böger CA
- Böhm BO
- Cambien F
- Campbell H
- Campbell S
- Campbell Harry
- Casas Juan P.
- Caulfield MJ
- Caulfield Mark J.
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- Chakravarti Aravinda
- Chambers JC
- Chambers John C.
- Chandak Giriraj R.
- Chang PP
- Chang Yen-Pei C.
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- Chasman Daniel I.
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- Cho Yoon Shin
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- Connell JM
- Connell John M.
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- Cooper Jackie A.
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- Coresh Josef
- Cornelis MC
- Corsi Anna Maria
- Cotlarciuc I
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- Couper D
- Cupples LA
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- Dahgam Santosh
- Dandona S
- Danesh John
- Davey Smith G
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- Kleefstra N
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- Knouf CW
- Knowles J
- Koenig W
- Kolcic I
- Kollerits B
- Kong A
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- Lehtimäki Terho
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- Rasheed Asif
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- Reffelmann T
- Reilly MP
- Renner W
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- Shuldiner AR
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- Smith George Davey
- Smith Nicholas L.
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- Snieder Harold
- Sober Siim
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- Spector Tim D.
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- Uda Manuela
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- Uitterlinden AG
- Uitterlinden AG
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- Wang TJ
- Wang TJ
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- Wang YA
- Wang Thomas J.
- Wang Xiaoling
- Wareham NJ
- Wareham Nicholas J.
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- Waterworth D
- Waterworth DM
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- Whitteman J
- Wichmann HE
- Wichmann HE
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- Wichmann H. -Erich
- Wiggins Kerri L.
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- Willenborg C
- Willerson JT
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- Wilson James F.
- Winkelmann BR
- Winkler K
- Witteman JC
- Witteman JC
- Witteman JC
- Witteman Jacqueline C. M.
- Wong Andrew
- Wong Tien Y.
- Wright AF
- Wright BJ
- Wright Alan F.
- Wu Ying
- Würtz Peter
- Yajnik Chittaranjan S.
- Yang Q
- Yao Jie
- Zaboli G
- Zelenika Diana
- Zeller T
- Zeller T
- Zeller T
- Zemunik T
- Zerres K
- Zgaga L
- Zhai Guangju
- Zhang W
- Zhang Feng
- Zhang Weihua
- Zhao Jing Hua
- Zhu Haidong
- Zhu Xiaofeng
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- Ziegler A
- Ziegler A
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- Zitting Paavo
- Zukowska-Szczechowska Ewa
- Zweiker R
- Publication venue
- Nature
- Publication date
- 01/01/2011
- Field of study
Blood pressure is a heritable trait influenced by several biological pathways and responsive to environmental stimuli. Over one billion people worldwide have hypertension (≥140 mm Hg systolic blood pressure or ≥90 mm Hg diastolic blood pressure). Even small increments in blood pressure are associated with an increased risk of cardiovascular events. This genome-wide association study of systolic and diastolic blood pressure, which used a multi-stage design in 200,000 individuals of European descent, identified sixteen novel loci: six of these loci contain genes previously known or suspected to regulate blood pressure (GUCY1A3-GUCY1B3, NPR3-C5orf23, ADM, FURIN-FES, GOSR2, GNAS-EDN3); the other ten provide new clues to blood pressure physiology. A genetic risk score based on 29 genome-wide significant variants was associated with hypertension, left ventricular wall thickness, stroke and coronary artery disease, but not kidney disease or kidney function. We also observed associations with blood pressure in East Asian, South Asian and African ancestry individuals. Our findings provide new insights into the genetics and biology of blood pressure, and suggest potential novel therapeutic pathways for cardiovascular disease prevention
The olfactory bulb as an independent developmental domain
- Author
- A Bulfone
- A Kawakami
- A Pini
- A Stoykova
- A-S LaMantia
- AJ Roskams
- B Malnic
- BL Hogan
- BL Schlaggar
- Brunjes
- C Zheng
- CA Byrd
- CA Greer
- D Jiménez
- DD O'Leary
- DM Cummings
- DM Lin
- E Meisami
- E Meisami
- E Stein
- EM Miyashita-Lin
- ET Stoeckli
- F De Castro
- F Valverde
- F Valverde
- FA Ebrahimi
- GS Jefferis
- H Treloar
- H Von Campenhausen
- HB Treloar
- HS Li
- J Fan
- JA De Carlos
- JA De Carlos
- JA Gogos
- JA St John
- JC Bartolomei
- JE Schwob
- JL Price
- JM Couper Leo
- JW Hinds
- JW Scott
- K Kalil
- K Patel
- KH Wang
- KT Nguyen Ba-Charvet
- KT Tisay
- L Belluscio
- L López-Mascaraque
- LC Williams-Hogarth
- LL Frazier
- M Devor
- M Yoshida
- MB Luskin
- MJ Donoghue
- MJ Renzi
- MS Bailey
- N Soussi-Yanicostas
- N Sugisaki
- OI Buiakova
- P Derer
- P Mombaerts
- P Rakic
- PC Brunjes
- PPC Graziadei
- Q Gong
- RP Stout
- S Konzelmann
- S Matsutani
- SA Bayer
- SA Goldman
- SA Przyborski
- SL Sullivan
- SM Potter
- T Fukuchi-Shimogori
- T Hirata
- T Hirata
- T Humphrey
- T Kitsukawa
- T Nakashiba
- T Seki
- T Shu
- TE Benson
- V Marillat
- VS Caviness Jr
- X Wang
- X Zhang
- Y Sato
- Z Zou
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Intoxikationen
- Author
- A Abderhalden
- A Ahlmark
- A Aigner
- A Albertini
- A Albertini
- A Arelarris
- A Ashford
- A Assls de
- A Bader
- A Bayet
- A Behrend
- A Bennecke
- A Biemond
- A Bingel
- A Birch-Hirschfeld
- A Birch-Hirschfeld
- A Birch-Hirschfeld
- A Blau
- A Bochkor
- A Bostroem
- A Bostroem
- A Braestrup
- A Braunmühl
- A Braunmühl
- A Braunmüiil
- A Braunmüiil
- A Braunmüiil
- A Brown
- A Burger
- A Buschke
- A Buschke
- A Buzzo
- A Bär
- A Cahn
- A Call
- A Canatni
- A Chesler
- A Chevalier
- A Chevalier
- A Chevalier
- A Christomanos
- A Christomanos
- A Christomanos
- A Costedoat
- A Courcoux
- A Courtois
- A Dellaporta
- A Dellaporta
- A Delpech
- A Delpech
- A Dietrich
- A Dietrich
- A Dowzenko
- A Dürck
- A Eldahl
- A Eldahl
- A Elschnigg
- A Enders
- A Erlicki
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- V Dhers
- V Fellenius
- V Gaupp
- V Kesztele
- V Koszler
- V Lachnpt
- V Leigheb
- V Meduna
- V Menon
- V Moellendorff
- V Monakow
- V Plavec
- V Tschisch
- V Zahle
- Vas
- Velden van der
- VH Vogel
- Villaverde
- Villaverde
- Villaverde
- Villaverde
- Villaverde
- VR Mason
- VR Mason
- W Altmann
- W Anschitz
- W Arcisz
- W Arnold
- W Beiglböck
- W Berger
- W Block
- W Blume
- W Blume
- W Blume
- W Boor de
- W Brainrussel
- W Bredemann
- W Brown
- W Cone
- W Cordes
- W Dameshek
- W Dontenwill
- W Ehrhardt
- W Filehne
- W Friemann
- W Gennerich
- W Goldfarb
- W Guiljarowski
- W Hay
- W Haymaker
- W Heine
- W Heineke
- W Heineke
- W Heinichen
- W Herkel
- W Hesse
- W Heubner
- W Heubner
- W Hoerburger
- W Hortsch
- W Huecx
- W Höfer
- W Höirer
- W Kat
- W Kirschbaum
- W Klein
- W Kürbitz
- W Laubender
- W Laubmann
- W Ludwig
- W Mahoney
- W Noell
- W Noell
- W Noell
- W Noell
- W Noell
- W Palmer
- W Paulus
- W Reiml
- W Reisert
- W Riese
- W Riese
- W Roehl
- W Rotter
- W Rotter
- W Rotter
- W Rotter
- W Schclz
- W Scholz
- W Scholz
- W Scholz
- W Scholz
- W Scholz
- W Scholz
- W Scholz
- W Scholz
- W Scholz
- W Schopper
- W Schorz
- W Schulemann
- W Schwarzacher
- W Schütze
- W Souullenberg
- W Spalteholz
- W Spielmeyer
- W Spielmeyer
- W Spielmeyer
- W Spielmeyer
- W Spielmeyer
- W Spielmeyer
- W Stecher
- W Steinbrinck
- W Stepp
- W Stich
- W Stocker
- W Straub
- W Uhthoff
- W Uhthoff
- W Uhthoff
- W Uhthoff
- W Wechselmann
- W Wechselmann
- W Weigeldt
- W Weigeldt
- W Weimann
- W Weimann
- W Weimann
- W Weimann
- W Weimann
- W Weimann
- W Weimann
- W Weimann
- W Weise
- W Wild
- WA Bastedo
- WA Horwitz
- WA Jacobs
- WA Jacobs
- WA Jacobs
- Wachholz
- Wagner-Jauregg
- Wassmuth
- WB Cadwalader
- WB Chew
- WC Black
- WD Mcnally
- WD Mcnally
- WD Vögtlin
- WE Clark
- WE Dixon
- WE Loomis
- WE Machle
- Weese
- Westphal
- WF Oettingen
- WG Haynes
- WG Lennox
- WG Lennox
- WG Lennox
- WG Lennox
- WG Spuiller
- WH Büel
- WH Eddy
- WH Hill
- WH Sebrell
- WH Sebrell
- Wieil
- Wiese
- Wirth
- WJ Buchanan
- WJ Dilling
- WJ Eicke
- WJ Eicre
- WJ Horsey
- WJ Horsey
- WJ Mccardie
- WJ Turner
- WJ Waters
- WJ Waters
- WJC Verhaart
- WJC Verhaart
- WJC Verhaart
- WK Hare
- WL Craddock
- WL Lillie
- WL Ritter
- WL Vögtlin
- WL Vögtlin
- WM Stephens
- WM Yater
- WN Aldrige
- WN Bispham
- WN Kemp
- WO Umiker
- Wohlwill
- Wolkow
- WP Lawson
- WR Bowen
- WR Hess
- WR Hess
- WR Hess
- WR Murray
- WT Haverfield
- WT Oettingen
- WU Mcclenahan
- WW Jetter
- WW Jetter
- WW Woons
- Y Jacksch
- Y Okamoto
- Y Tsiminakis
- YC Chang
- Z Swetnik
- Z Wechsler
- Z Wechsler
- Zangger
- Ziegler
- Zutt
- Ä Swansson
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1958
- Field of study