5 research outputs found
Preliminary safety and efficacy of first-line pertuzumab combined with trastuzumab and taxane therapy for HER2-positive locally recurrent or metastatic breast cancer (PERUSE).
- Author
- Abdel Azeem H
- Abulkhair O
- Achille M
- Aksoy S
- Alabiso O
- Alarc\uf3n J
- Aleknavicius E
- Alexandre J
- Allen M
- Alonso I.
- Alonso JL
- Altwegeiri T
- Amorim G
- Andel J
- Andrade J
- Andreetta C
- Andres Conejero R
- Angel Garcia J
- Ant\uf3n Torres A
- Arance A
- Arcediano A
- Artignan X
- Augereau P
- Aziz Z
- Azribi F
- Bachelot T
- Bachmeier K
- Baird R
- Barletta H
- Barnadas Molins A
- Barraclough L
- Barrett S
- Barrios C
- Baruch NB
- Beato C
- Beith J
- Berdah JF
- Beresford M
- Bernstein V
- Bj\uf6meklett HG
- Bodoky G
- Boer K
- Bondarenko I
- Bonetti A
- Bourgeois H
- Brain E
- Butt M
- Califaretti N
- Campone M
- Cariello A
- Cascinu S
- Castillo C
- Catala S
- Cavero M
- Cede\uf1o M
- Chakraborti P
- Christensen B
- Cicin I
- Ciruelos E
- Cocquyt V
- Cort\ue9s J
- Coskun HS
- Costa L
- Coudert B
- Cruz M
- Curigliano G
- Dalenc F
- Dalmau E
- Damasceno M
- De Boer R
- de Gr\ue8ve J
- de Jongh F
- de la Cruz LR
- de Prado DS
- Del Mar Gordon M
- Del Val O
- Di Costanzo F
- Dohollou N
- Dominguez A
- du Toit Y
- Easton V
- Echarri MJ
- Efremidou A
- El-Saghir N
- Errihani H
- Ettl J
- Evron E
- Facchini T
- Fein LE
- Feng J
- Ferra\uf9 F
- Ferreira A
- Fountzilas G
- Fox S
- Frassoldati A
- Fried G
- Gaafar R
- Gal\ue1n A
- Garate CO
- Garc\ueda M
- Garcia Mata J
- Garcia A
- Garcia L
- Garre EG
- Geffen D
- Genet D
- Gennari A
- Ghosn M
- Giacobino A
- Gianni L
- Goldberg H
- Goncalves A
- Gonzalez A
- Gozy M
- Grasso D
- Greil R
- Gridelli C
- Grischke EM
- Grosjean J
- Guerra YC
- Hegg R
- Hernandez C
- Hesse T
- Hicks J
- Hicks J
- Hoffmann O
- Hu X
- Huizing M
- Humphreys A
- Illarramendi JJ
- Inbar M
- Jafri M
- Jerusalem G
- Jes\ufas Flori\ue1n Jerico MS
- Jiang J
- Jiveliouk I
- Joffe J
- Joy A
- Juarez A
- Juhasz B
- Juhasz-Boess I
- Juozaityte E
- K\ufchn T
- K\ufctner R
- Kaen LA
- Kahan Z
- Kalofonos H
- Karminsky N
- Khandan F
- Klint L
- Kovalyov O
- Kukulska M
- L\uf3pez L\uf3pez R
- Laing R
- Lang I
- Laplaige P
- Largillier R
- Latini L
- Lazaro J
- Levitt N
- Li H
- Li N
- Li N
- Lindegger N
- Llombart A
- Llorca C
- Llorente R
- Loman N
- Lopez Ceballos MH
- Lueck HJ
- Luigi C
- Lux M
- Mano M
- Mart\uednez Ja\uf1ez N
- Martin P
- Martinez E
- Martinez MP
- Matos E
- Mattson J
- Matus J
- Mavroudis D
- McAdam K
- McCarthy N
- Mele M
- Menj\uf3n Beltr\ue1n S
- Merot JL
- Miles D
- Montemurro F
- Mueller V
- Murias A
- Narbe U
- Newby J
- Ngan R
- Nowecki Z
- Ober A
- Oltra A
- Oosterkamp R
- Orfeuvre H
- Ozyilkan O
- Padrik P
- Paluch-Shimon S
- Panasci L
- Panwar U
- Papazisis K
- Passos Coelho JL
- Pectasides D
- Pelaez I
- Peretz-Yablonski T
- Perez M
- Peron YI
- Perren T
- Perrin C
- PERUSE investigators: Bouzid K
- Petzer A
- Poole C
- Pottier V
- Puglisi F
- Rafael Rodriguez Cid J
- Rashid K
- Rayson D
- Redondo A
- Repp R
- Revesz J
- Ribelles N
- Ricci F
- Rigg A
- Robidoux A
- Rodr\uedguez R
- Rodriguez C
- Roerdink H
- Rosengarten O
- Ruggeri EM
- Ruohola J
- Saad Eldin I
- Saarni O
- Salas F
- Sanchez R
- Saura S
- Schmid P
- Schneeweiss A
- Schroeder W
- Sehdev S
- Shparyk Y
- Siddiqi N
- Simon E
- Singer C
- Smiljanic S
- Smok-Kalwat J
- Soria T
- Sousa G
- Steger G
- Stemmer S
- Stoeger H
- Streb J
- Stuart-Harris R
- Susnjar S
- Tanner M
- Taylor W
- Teixeira L
- Tondini C
- Tong Z
- Torrego JC
- Trifunovic J
- Turner N
- Uslu R
- V\ue1squez FM
- Van de Wouw Y
- Van den Bosch J
- Van der Velden A
- Van Warmerdam L
- Varughese M
- Vasilopoulos G
- Vera R
- Verma S
- Verrill M
- Vi\uf1as Villaro G
- Voitko N
- von Schumann R
- Vrijaldenhoven S
- Wagner S
- Wang S
- Wardley A
- Waters S
- Westwell S
- Wheatley D
- Wildiers H
- Wojtukiewicz M
- Woodward N
- Wronski A
- Yeo B
- Yordi G
- Zahm DM
- Zhang Q
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2019
- Field of study
BACKGROUND:
Pertuzumab combined with trastuzumab and docetaxel is the standard first-line therapy for HER2-positive metastatic breast cancer, based on results from the phase III CLEOPATRA trial. PERUSE was designed to assess the safety and efficacy of investigator-selected taxane with pertuzumab and trastuzumab in this setting.
PATIENTS AND METHODS:
In the ongoing multicentre single-arm phase IIIb PERUSE study, patients with inoperable HER2-positive advanced breast cancer (locally recurrent/metastatic) (LR/MBC) and no prior systemic therapy for LR/MBC (except endocrine therapy) received docetaxel, paclitaxel or nab-paclitaxel with trastuzumab [8\u2009mg/kg loading dose, then 6\u2009mg/kg every 3\u2009weeks (q3w)] and pertuzumab (840\u2009mg loading dose, then 420\u2009mg q3w) until disease progression or unacceptable toxicity. The primary end point was safety. Secondary end points included overall response rate (ORR) and progression-free survival (PFS).
RESULTS:
Overall, 1436 patients received at least one treatment dose (initially docetaxel in 775 patients, paclitaxel in 589, nab-paclitaxel in 65; 7 discontinued before starting taxane). Median age was 54\u2009years; 29% had received prior trastuzumab. Median treatment duration was 16\u2009months for pertuzumab and trastuzumab and 4\u2009months for taxane. Compared with docetaxel-containing therapy, paclitaxel-containing therapy was associated with more neuropathy (all-grade peripheral neuropathy 31% versus 16%) but less febrile neutropenia (1% versus 11%) and mucositis (14% versus 25%). At this preliminary analysis (52 months' median follow-up), median PFS was 20.6 [95% confidence interval (CI) 18.9-22.7] months overall (19.6, 23.0 and 18.1\u2009months with docetaxel, paclitaxel and nab-paclitaxel, respectively). ORR was 80% (95% CI 78%-82%) overall (docetaxel 79%, paclitaxel 83%, nab-paclitaxel 77%).
CONCLUSIONS:
Preliminary findings from PERUSE suggest that the safety and efficacy of first-line pertuzumab, trastuzumab and taxane for HER2-positive LR/MBC are consistent with results from CLEOPATRA. Paclitaxel appears to be a valid alternative taxane backbone to docetaxel, offering similar PFS and ORR with a predictable safety profile.
CLINICALTRIALS.GOV:
NCT01572038
Influence of Storage Time of Moringa oleifera seed on the coagulant activity efficiency for raw water treatment
- Author
- Antov MG Sciban MB, Prodanovic JM.
- Baptista ATA Silva MO, Guttierres R, Bergamasco R, Vieira MF, Vieira AMS.
- Bobbarala V Kumar P, Chandrasekhar K, Penumajji S.
- Dange PS Lad RK.
- De Paula HM De Oliveira MS, Sarmento AP, Andrade LS.
- Feria JJ Berm�dez S, Estrada AM.
- Feria JJ Rodi-o JP, Gutierrez GE.
- Feria JJ Tavera MJ, Perna O.
- Fernandez GH Alves J, Angelo AM, Albuquerque R, Silva dos Fernandes RH.
- Katayon S Noor MJ, Asma M, Ghani LA, Thamer AM, Azni I, Ahmad J, Khor BC, Suleyman AM.
- Kaur A Sharma S.
- L�pez S Mat�as CA, Mat�as D, Garc�a IA.
- Nasirian H Nazmara S, Hossein A, Hosseini M, Shiri L, Vazirianzadeh B.
- Okuda T Baes AU, Nishijima W, Okada M.
- Rodi-o J Feria JJ, Paternina R, Marrugo J.
- Rungrodnimitchai S.
- Salazar LL Luna M, Salazar R.
- Scaramal G Bordini G, Marquetotti A, Nishi L, Cordeiro K, Bergamasco R.
- Scaramal G Guilherme I, Jurca V, De Abreu Alves B, Fagundes M, Bergamasco R.
- Sulaiman M Andrawus D, Mohammed K, Mohammed D, Aliyu B, Abd Manan F.
- S�nchez J Beltr�n J, Peres JA.
- Yogeswari M Sham B, Ganesan P.
- Publication venue
- 'Indian Society for Education and Environment'
- Publication date
- Field of study
Structural and Magnetic Properties of Transition-Metal-Doped Zn 1−x Fe x O
- Author
- A Kaushik
- A Parra-Palomino
- A Tsukazaki
- A Tsukazaki
- A Zunger
- AK Mishra
- AS Risbud
- B. Anis
- BD Cullity
- Chun-Gang Duan
- CNR Rao
- D Karmakar
- D Song
- DW Chu
- E Vincent
- F Li
- G Kresse
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- G Lawes
- GY Ahn
- GY Ahn
- GZ Xing
- H Chang
- H Gu
- IA Sarsari
- J T-Thienprasert
- JB Wang
- JJ Beltr
- JP Perdew
- K Sato
- K Sato
- K Srinivas
- K Ueda
- L Patterson
- LB Duan
- M Karyaoui
- M Liu
- M Ungureanu
- Mahmoud Abdel-Hafiez
- MHF Sluiter
- NH Hong
- PD Sahare
- PK Sharma
- Q Wang
- R Janisch
- RN Aljawfi
- S Karamat
- S Kumar
- S Nakamura
- S Singh
- S Singh
- S Thota
- SJ Pearton
- SW Yoon
- T Dietl
- T Dietl
- T Kataoka
- T Pandiyarajan
- T. A. Abdel-Baset
- W Cheng
- Y Lin
- Y Liu
- Y Wang
- Y Zhang
- Y Zhou
- Yue-Wen Fang
- Z Jin
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Body mass index and complications following major gastrointestinal surgery: a prospective, international cohort study and meta-analysis.
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- Telfer R
- Temiz C
- Teng V
- Teoh Pj
- Ter Bruggen Ffja
- Ter Horst L
- Ter Weele K
- Thacoor A
- Thakker Ce
- Thakur H
- Tharakan Rg
- Tharmachandirar T
- Theodoreson Md
- Theodoropoulou K
- Thethi R
- Thevathasan Aa
- Thirumal V
- Thomas D
- Thomas G
- Thomas-Davies M
- Thompson Jd
- Thompson Od
- Tiedt L
- Tilston Tw
- Tippins F
- Tirnaksiz Mb
- Toale C
- Tognolo L
- Toh C
- Tomas K
- Toner E
- Tongo F
- Tonkins M
- Toorenvliet Br
- Topal U
- Topalan K
- Topham C
- Torlot Ge
- Torrance Hd
- Tosun V
- Toto Of
- Trail M
- Traynor Bp
- Trecarten S
- Trimble A
- Trist Aj
- Troia A
- Trompetto M
- Truma A
- Truss A
- Tsui Ay
- Tulum H
- Tung L
- Turaga S
- Turati L
- Turkmen M
- Turley H
- Turnbull Ja
- Turner Ejh
- Turner J
- Turner L
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- Tutam Dn
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- Uctepe F
- Uittenbogaart M
- Ulkucu A
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- Uppal E
- Urquhart A
- Uzun B
- Uzun O
- Uzun S
- Uzunoglu Ec
- Vable T
- Valderrama P\ue9rez A
- Valli A
- Vallve-Bernal M
- Van Bruggen D
- van Dalen Ashm
- van de Ven Awh
- van der Harst E
- van der Hoeven Ac
- Van der Lubbe M
- van der Pool Aem
- van der Zee C
- Van Dijck Wpm
- van Elst Tr
- van Engelenburg T
- van Geloven A
- Van Grevenstein Wmu
- Van Heumen Tm
- van Leeuwen Bl
- van Rijckevorsel Vajim
- van Steensel L
- Van Tol Rr
- van Verschuer Vmt
- van Wijnbergen Jwm
- Vanmali P
- Varley R
- Varma D
- Varma N
- Varma Rk
- Varo Mu\uf1oz A
- Vasko P
- Vasquez G
- Vaughan R
- Vazquez-Gonzalez I
- Veenker Cgh
- Vela Polanco Ff
- Vendramin E
- Venn M
- Ventre Cm
- Venturini S
- Verardi L
- Verboeket B
- Verma K
- Verma S
- Vermaas M
- Vernon Ok
- Vi\uf1as-Salas J
- Villarejo Campos P
- Vinci A
- Vithanage Na
- Vivekanantham S
- Vives-Rodriguez E
- Vries Jjm
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- Wali A
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- Webb E
- Weinberg D
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- Whewell H
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- White U
- Whitehurst K
- Whitham Rdj
- Whittingham H
- Wiersema R
- Wiezer R
- Wijesekera M
- Wijffels N
- Wijnhoven Bpl
- Wild Jrl
- Wilkinson D
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- Willems Yr
- Williams M
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- Wills J
- Wilson H
- Wilson Hcp
- Wilson R
- Wilson T
- Wiltshire Jj
- Winarski A
- Wing Vc
- Wingfield Lr
- Winslow F
- Woin E
- Wong C
- Wong E
- Wong V
- Wood Ad
- Woodcock N
- Woodward H
- Woon E
- Wright A
- Wright Ev
- Wye J
- Wylam D
- Wylie J
- Wynell-Mayow Wm
- Xiao C
- Xu Gx
- Xylas D
- Y\u131gman S
- Yalcin Y
- Yaman S
- Yan A
- Yang T
- Yasar C
- Yates Ja
- Yauw S
- Yavuz G
- Yazkan Z
- Yekenkurul E
- Yener A
- Yeoh Tsl
- Yetiskin E
- Yildirim N
- Yildirim R
- Yildiz S
- Yildiz Ss
- Yildiz T
- Yilmaz I
- Yilmaz M
- Yilmaz S
- Yilmaz T
- Yim N
- Yoganathan S
- Yong Cs
- Yong N
- Yoruk I
- Yousif A
- Yow L
- Yuen R
- Yuksek B
- Yuksek Ma
- Yuksel A
- Yurdaor Ss
- Yurekli Am
- Zaidi R
- Zegeye Mi
- Zengin T
- Zhang Aa
- Zhao J
- Ziff O
- Zigiotto D
- Zijlmans Jl
- Zimmerman D
- Ziprin P
- Zope S
- Zuhair M
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2018
- Field of study
AIM:
Previous studies reported conflicting evidence on the effects of obesity on outcomes after gastrointestinal surgery. The aims of this study were to explore the relationship of obesity with major postoperative complications in an international cohort and to present a meta-analysis of all available prospective data.
METHODS:
This prospective, multicentre study included adults undergoing both elective and emergency gastrointestinal resection, reversal of stoma or formation of stoma. The primary end-point was 30-day major complications (Clavien-Dindo Grades III-V). A systematic search was undertaken for studies assessing the relationship between obesity and major complications after gastrointestinal surgery. Individual patient meta-analysis was used to analyse pooled results.
RESULTS:
This study included 2519 patients across 127 centres, of whom 560 (22.2%) were obese. Unadjusted major complication rates were lower in obese vs normal weight patients (13.0% vs 16.2%, respectively), but this did not reach statistical significance (P = 0.863) on multivariate analysis for patients having surgery for either malignant or benign conditions. Individual patient meta-analysis demonstrated that obese patients undergoing surgery for malignancy were at increased risk of major complications (OR 2.10, 95% CI 1.49-2.96, P < 0.001), whereas obese patients undergoing surgery for benign indications were at decreased risk (OR 0.59, 95% CI 0.46-0.75, P < 0.001) compared to normal weight patients.
CONCLUSIONS:
In our international data, obesity was not found to be associated with major complications following gastrointestinal surgery. Meta-analysis of available prospective data made a novel finding of obesity being associated with different outcomes depending on whether patients were undergoing surgery for benign or malignant disease
The plant translational apparatus
- Author
- A Benedetti De
- A Chakrabarti
- A Flynn
- A Heerden Van
- A Lazaris-Karatzas
- A Mahe
- A Makkinje
- A Pause
- A Pause
- A Pay
- A Perez-Mendez
- AAM Thomas
- AC Nairn
- AG Hinnebusch
- AG Ryazanov
- AG Ryazanov
- AG Ryazanov
- AG Ryazanov
- AJ Fleming
- AK Huttly
- AM Mehta
- AM Metz
- AM Metz
- AM Metz
- AM Metz
- AM Pappenheimer Jr
- AM Perlick
- AR Pokalsky
- B Chaudhry
- B Floyd
- B Golinska
- B Hay
- B Joshi
- B Riis
- B Stankovic
- BG Ness Van
- BK Ray
- BS Pater De
- C Curie
- C Curie
- C Curie
- C Goyer
- C Gualerzi
- C Heufler
- C Wang
- C Webster
- C Webster
- C Wei
- C-L Wei
- CE Samuel
- CG Proud
- CG Proud
- CK Shewmaker
- CL Bokros
- CT Caskey
- D Bevec
- D Chakravarti
- D Chamot
- D Curtis
- D Etchison
- D St Johnston
- D Thiele
- DA Ornelles
- DA Wasserman
- DC Eustice
- DL Melanson
- DM Valenzucla
- DR Gallie
- DW Russell
- E Beltr�n-Pe�a
- E Ceglarz
- E Davies
- E Davies
- E Fehling
- E Fehling
- E Palen
- EA Robinson
- EG Fey
- EH Harris
- ES Maxwell
- F Aguilar
- F Omura
- F Sutton
- F Yang
- G Hansen
- G Hern�ndez
- G Lu
- G Monke
- G Zhouravleva
- GD Schuler
- GDF Maessen
- GJ Bassell
- GMC Janssen
- GMC Janssen
- GMC Janssen
- GMC Janssen
- GW Owttrim
- GW Owttrim
- H Damme Van
- H Mitsui
- H Yoon
- HA Kang
- HAA Heugten Van
- HB Krishnan
- HB Mehta
- HF Noller
- HJ Himmelfarb
- HM Hanauske-Abel
- HM Hanauske-Abel
- HO Voorma
- HO Voorma
- HO Voorma
- HP Braun
- HR Bourne
- HTF Damme Van
- I Hwang
- I Marty
- I Nakamura
- I Stansfield
- I Stansfield
- IG Wool
- J Bailey-Serres
- J Cavallius
- J Chaudhuri
- J Chevesich
- J Condeelis
- J Gao
- J Gao
- J Humphreys
- J Mundy
- J Sanders
- J Sanders
- J Schnier
- J Scoble
- J Yoder-Hill
- J-J Chen
- JA Grifo
- JA Lenstra
- JC Larkin
- JD Hugdahl
- JE Habben
- JE Hesketh
- JF Carvalho
- JG Howe
- JJ Osterhout
- JK Morelli
- JK Zhu
- JO Langland
- JO Langland
- JP Perentesis
- JP Stafstrom
- JP Stafstrom
- JPG Ballestra
- JS Butler
- JS Gantt
- JS Gantt
- JS Gantt
- JW Bodley
- JW Bodley
- JW Checkley
- JW Raff
- JWB Hershey
- JWB Hershey
- JWB Hershey
- JY Chen
- JY Chen
- K Das
- K Kongsuwan
- K Luby-Phelps
- K Moldave
- K Nagashima
- KA Brander
- KA Brander
- KD Scharf
- KD Scharf
- KS Browning
- KS Browning
- KS Browning
- KS Browning
- KS Browning
- KS Browning
- KS Browning
- KS Browning
- L Barbieri
- L Frolova
- L Montesano
- L Montesano
- L P�rez
- LA Benkowski
- LC Mattheakis
- LD Phan
- LE Littlepage
- LH Campbell
- LH Madsen
- LI Slobin
- LI Slobin
- LL Spremulli
- M Altmann
- M Altmann
- M Altmann
- M Altmann
- M Axelos
- M Bektas
- M Garcia-Hernandez
- M Jaramillo
- M Kozak
- M Kozak
- M Kozak
- M Lebrun
- M Lijsebettens Van
- M Ruhl
- M Sha
- M Wakiyama
- MA Dunn
- MA Taylor
- MA Taylor
- MAM Kasperaitis
- MD Adams
- ME Vayda
- ME Vayda
- MF Tuite
- MG Rosenfeld
- MH Park
- MH Park
- MH Schreier
- MJ Clemens
- ML Allen
- ML Balasta
- MM Sikorski
- MT Garcia-Barrio
- N Datta
- N Oizumi
- N Price
- N Sonenberg
- N Sonenberg
- NA Durso
- NG Kambouris
- NJ Oppenheimer
- O Nyg�rd
- P Cammarano
- P Cammarano
- P Cammarano
- P Joanin
- P Lenk
- P Linder
- P Linder
- P Raychaudhuri
- P Silar
- PC Bonham-Smith
- PC Bonham-Smith
- PG Wilson
- PJ Nielsen
- R Amons
- R Benne
- R Benne
- R Bollini
- R Coppolecchia
- R Kaempfer
- R Kawahara
- R Nishi
- R Nishi
- R Nishi
- R Perez-Bercoff
- R Werner
- R Yan
- RB Turley
- RB Turley
- RB Turley
- RC Venema
- RC Venema
- RC Wek
- RD Abramson
- RD Clarke
- RE Rhoads
- RE Rhoads
- RE Rhoads
- RE Rhoads
- RE Thach
- RH Singer
- RPC Valle
- RT Timmer
- S Andersson
- S Cho
- S Ejiri
- S Ejiri
- S Ejiri
- S Ejiri
- S Hasezawa
- S Jayachandran
- S Kidou
- S Lax
- S Mader
- S Matsumoto
- S Matsumoto
- S Penman
- S Reinbothe
- S Reinbothe
- SC Milburn
- SE Carberry
- SE Carberry
- SE Carberry
- SE Carberry
- SH Zhang
- SJ Lauer
- SJ Lauer
- SJ Lauer
- SK Smailov
- SM Shaikhin
- SN Seal
- SN Seal
- SN Seal
- SN Seal
- SN Seal
- SN Seal
- SN Seal
- SR Lax
- SR Lax
- SR Lax
- T Berberich
- T Liboz
- T Mizoguchi
- T Naranda
- T Naranda
- T Twardowski
- TA Jongens
- TE Dever
- TE Dever
- TG Kinzy
- TL Ripmaster
- TR Lenvik
- U Warskulat
- V Sangwan
- VM Pain
- VM Pain
- VM Ursin
- W Rychlik
- W Yang
- W Yang
- W You
- WC Merrick
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- WC Merrick
- WC Merrick
- WJ Iglewski
- Y Fujiwara
- Y Hihara
- Y Ito
- Y Kim
- Y Kimata
- Z Smit-McBride
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study