Transdiagnostic treatment of bipolar disorder and comorbid anxiety using the Unified Protocol for Emotional Disorders: A pilot feasibility and acceptability trial

BACKGROUND Comorbid anxiety in bipolar disorder (BD) is associated with greater illness severity, reduced treatment response, and greater impairment. Treating anxiety in the context of BD is crucial for improving illness course and outcomes. The current study examined the feasibility, acceptability and preliminary efficacy of the Unified Protocol (UP), a transdiagnostic cognitive behavioral therapy, as an adjunctive treatment to pharmacotherapy for BD and comorbid anxiety disorders. METHODS Twenty-nine patients with BD and at least one comorbid anxiety disorder were randomized to pharmacotherapy treatment-as-usual (TAU) or TAU with 18 sessions of the UP (UP+TAU). All patients completed assessments every four weeks to track symptoms, functioning, emotion regulation and temperament. Linear mixed-model regressions were conducted to track symptom changes over time and to examine the relationship between emotion-related variables and treatment response. RESULTS Satisfaction ratings were equivalent for both treatment groups. Patients in the UP+TAU group evidenced significantly greater reductions over time in anxiety and depression symptoms (Cohen's d's>0.80). Baseline levels of neuroticism, perceived affective control, and emotion regulation ability predicted magnitude of symptom change for the UP+TAU group only. Greater change in perceived control of emotions and emotion regulation skills predicted greater change in anxiety related symptoms. LIMITATIONS This was a pilot feasibility and acceptability trial; results should be interpreted with caution. CONCLUSIONS Treatment with the UP+TAU was rated high in patient satisfaction, and resulted in significantly greater improvement on indices of anxiety and depression relative to TAU. This suggests that the UP may be a feasible treatment approach for BD with comorbid anxiety.This work was supported by a Postdoctoral National Research Service Award from the National Institutes of Health [F32 MH098490] to K. Ellard. (F32 MH098490 - Postdoctoral National Research Service Award from the National Institutes of Health)Accepted manuscrip

CHEMICAL DIVERSITY IN THE ULTRA-FAINT DWARF GALAXY TUCANA II

We present the first detailed chemical abundance study of the ultra-faint dwarf galaxy Tucana II, based on high-resolution Magellan/MIKE spectra of four red giant stars. The metallicities of these stars range from [Fe/H] = −3.2 to −2.6, and all stars are low in neutron-capture abundances ([Sr/Fe] and [Ba/Fe] < −1). However, a number of anomalous chemical signatures are present. One star is relatively metal-rich ([Fe/H] = −2.6) and shows [Na, α, Sc/Fe] < 0, suggesting an extended star formation history with contributions from AGB stars and SNe Ia. Two stars with [Fe/H] < −3 are mildly carbon-enhanced ([C/Fe] ~ 0.7) and may be consistent with enrichment by faint supernovae, if such supernovae can produce neutron-capture elements. A fourth star with [Fe/H] = −3 is carbon-normal, and exhibits distinct light element abundance ratios from the carbon-enhanced stars. This carbon-normal star implies that at least two distinct nucleosynthesis sources, both possibly associated with Population III stars, contributed to the early chemical enrichment of this galaxy. Despite its very low luminosity, Tucana II shows a diversity of chemical signatures that preclude it from being a simple "one-shot" first galaxy yet still provide a window into star and galaxy formation in the early universe.National Science Foundation (U.S.) (AST- 1255160)National Science Foundation (U.S.) (PHY-1430152

Exponential stability of delayed recurrent neural networks with Markovian jumping parameters

This is the post print version of the article. The official published version can be obtained from the link below - Copyright 2006 Elsevier Ltd.In this Letter, the global exponential stability analysis problem is considered for a class of recurrent neural networks (RNNs) with time delays and Markovian jumping parameters. The jumping parameters considered here are generated from a continuous-time discrete-state homogeneous Markov process, which are governed by a Markov process with discrete and finite state space. The purpose of the problem addressed is to derive some easy-to-test conditions such that the dynamics of the neural network is stochastically exponentially stable in the mean square, independent of the time delay. By employing a new Lyapunov–Krasovskii functional, a linear matrix inequality (LMI) approach is developed to establish the desired sufficient conditions, and therefore the global exponential stability in the mean square for the delayed RNNs can be easily checked by utilizing the numerically efficient Matlab LMI toolbox, and no tuning of parameters is required. A numerical example is exploited to show the usefulness of the derived LMI-based stability conditions.This work was supported in part by the Engineering and Physical Sciences Research Council (EPSRC) of the UK under Grant GR/S27658/01, the Nuffield Foundation of the UK under Grant NAL/00630/G, and the Alexander von Humboldt Foundation of Germany

Tropical Atlantic climate response to low-latitude and extratropical sea-surface temperature : a Little Ice Age perspective

Author Posting. © American Geophysical Union, 2009. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Geophysical Research Letters 36 (2009): L11703, doi:10.1029/2009GL038677.Proxy reconstructions and model simulations suggest that steeper interhemispheric sea surface temperature (SST) gradients lead to southerly Intertropical Convergence Zone (ITCZ) migrations during periods of North Atlantic cooling, the most recent of which was the Little Ice Age (LIA; ∼100–450 yBP). Evidence suggesting low-latitude Atlantic cooling during the LIA was relatively small (<1°C) raises the possibility that the ITCZ may have responded to a hemispheric SST gradient originating in the extratropics. We use an atmospheric general circulation model (AGCM) to investigate the relative influence of low-latitude and extratropical SSTs on the meridional position of the ITCZ. Our results suggest that the ITCZ responds primarily to local, low-latitude SST anomalies and that small cool anomalies (<0.5°C) can reproduce the LIA precipitation pattern suggested by paleoclimate proxies. Conversely, even large extratropical cooling does not significantly impact low-latitude hydrology in the absence of ocean-atmosphere interaction.This work was supported by NSF grants OCE 0623364 and ATM 033746 as well as the student research fund of MIT’s Department of Earth, Atmospheric and Planetary Science

The R-Process Alliance: Chemical Abundances for a Trio of R-Process-Enhanced Stars -- One Strong, One Moderate, One Mild

We present detailed chemical abundances of three new bright (V ~ 11), extremely metal-poor ([Fe/H] ~ -3.0), r-process-enhanced halo red giants based on high-resolution, high-S/N Magellan/MIKE spectra. We measured abundances for 20-25 neutron-capture elements in each of our stars. J1432-4125 is among the most r-process rich r-II stars, with [Eu/Fe]= +1.44+-0.11. J2005-3057 is an r-I star with [Eu/Fe] = +0.94+-0.07. J0858-0809 has [Eu/Fe] = +0.23+-0.05 and exhibits a carbon abundance corrected for evolutionary status of [C/Fe]_corr = +0.76, thus adding to the small number of known carbon-enhanced r-process stars. All three stars show remarkable agreement with the scaled solar r-process pattern for elements above Ba, consistent with enrichment of the birth gas cloud by a neutron star merger. The abundances for Sr, Y, and Zr, however, deviate from the scaled solar pattern. This indicates that more than one distinct r-process site might be responsible for the observed neutron-capture element abundance pattern. Thorium was detected in J1432-4125 and J2005-3057. Age estimates for J1432-4125 and J2005-3057 were adopted from one of two sets of initial production ratios each by assuming the stars are old. This yielded individual ages of 12+-6 Gyr and 10+-6 Gyr, respectively.Comment: 30 pages, includes a long table, 5 figure

Measuring Accuracy of Automated Parsing and Categorization Tools and Processes in Digital Investigations

This work presents a method for the measurement of the accuracy of evidential artifact extraction and categorization tasks in digital forensic investigations. Instead of focusing on the measurement of accuracy and errors in the functions of digital forensic tools, this work proposes the application of information retrieval measurement techniques that allow the incorporation of errors introduced by tools and analysis processes. This method uses a `gold standard' that is the collection of evidential objects determined by a digital investigator from suspect data with an unknown ground truth. This work proposes that the accuracy of tools and investigation processes can be evaluated compared to the derived gold standard using common precision and recall values. Two example case studies are presented showing the measurement of the accuracy of automated analysis tools as compared to an in-depth analysis by an expert. It is shown that such measurement can allow investigators to determine changes in accuracy of their processes over time, and determine if such a change is caused by their tools or knowledge.Comment: 17 pages, 2 appendices, 1 figure, 5th International Conference on Digital Forensics and Cyber Crime; Digital Forensics and Cyber Crime, pp. 147-169, 201

The time to perform spinal or general anaesthesia in COVID-19 positive parturients requiring emergency caesarean delivery: a prospective crossover simulation study

Background: Spinal anaesthesia is the commonest performed technique for caesarean deliveries except in the emergency setting where general anaesthesia is preferred due to its rapid onset and predictability. There are several modifications to performing general anaesthesia for COVID-19 patients in Australia. We hypothesised that the performance time of these techniques amongst specialist anaesthetists would be similar for COVID-19 parturients undergoing emergency caesarean delivery. Methods: We designed a simulation cross-over study. The primary outcome was the time taken to perform general anaesthesia or spinal anaesthesia in this setting. We also examined the decision-making process time, the decision to incision time and the level of stress associated with both scenarios. Results: Nine specialist anaesthetists participated in the research. There was no difference in the time taken to perform spinal or general anaesthesia (mean difference (GA–SA scenario) –1.2 (–5.3–2.8) minutes, p = 0.5). Irrespective of group allocation the mean time to complete the spinal anaesthesia scenario was 27.4 (standard deviation = 7.8) minutes, while for the general anaesthesia scenario was 24.0 (7.2) minutes. There was no difference between these times (mean difference (GA–SA scenario) = –3.5 minutes, 95th percent confidence interval –9.7–2.8 minutes, p = 0.24). There was no evidence of a carryover effect for the two scenarios based on the group allocation (p = 0.69) and no significant difference between stress levels (p = 0.44). Conclusions: The time to perform spinal anaesthesia was similar to the time to perform general anaesthesia for a confirmed COVID-19 parturient in a simulation environment

Lattice polytopes from Schur and symmetric Grothendieck polynomials

Given a family of lattice polytopes, two common questions in Ehrhart Theory are determining when a polytope has the integer decomposition property and determining when a polytope is reflexive. While these properties are of independent interest, the confluence of these properties is a source of active investigation due to conjectures regarding the unimodality of the $h^\ast$-polynomial. In this paper, we consider the Newton polytopes arising from two families of polynomials in algebraic combinatorics: Schur polynomials and inflated symmetric Grothendieck polynomials. In both cases, we prove that these polytopes have the integer decomposition property by using the fact that both families of polynomials have saturated Newton polytope. Furthermore, in both cases, we provide a complete characterization of when these polytopes are reflexive. We conclude with some explicit formulas and unimodality implications of the $h^\ast$-vector in the case of Schur polynomials.Comment: 37 pages, 3 tables, 4 figures; Comments Welcome; Version 2: updated references to acknowledge one result was previously known, corrected values in Table 1 and reference correct OEIS sequence; Version 3: Final Version. To appear in Electronic Journal of Combinatoric

Exponential synchronization of complex networks with Markovian jump and mixed delays

This is the post print version of the article. The official published version can be obtained from the link - Copyright 2008 Elsevier LtdIn this Letter, we investigate the exponential synchronization problem for an array of N linearly coupled complex networks with Markovian jump and mixed time-delays. The complex network consists of m modes and the network switches from one mode to another according to a Markovian chain with known transition probability. The mixed time-delays are composed of discrete and distributed delays, both of which are mode-dependent. The nonlinearities imbedded with the complex networks are assumed to satisfy the sector condition that is more general than the commonly used Lipschitz condition. By making use of the Kronecker product and the stochastic analysis tool, we propose a novel Lyapunov–Krasovskii functional suitable for handling distributed delays and then show that the addressed synchronization problem is solvable if a set of linear matrix inequalities (LMIs) are feasible. Therefore, a unified LMI approach is developed to establish sufficient conditions for the coupled complex network to be globally exponentially synchronized in the mean square. Note that the LMIs can be easily solved by using the Matlab LMI toolbox and no tuning of parameters is required. A simulation example is provided to demonstrate the usefulness of the main results obtained.This work was supported in part by the Biotechnology and Biological Sciences Research Council (BBSRC) of the UK under Grants BB/C506264/1 and 100/EGM17735, the Engineering and Physical Sciences Research Council (EPSRC) of the UK under Grants GR/S27658/01 and EP/C524586/1, an International Joint Project sponsored by the Royal Society of the UK, the Natural Science Foundation of Jiangsu Province of China under Grant BK2007075, the National Natural Science Foundation of China under Grant 60774073, and the Alexander von Humboldt Foundation of Germany