147 research outputs found
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When the past comes back to haunt you: the enduring influence of upbringing on the work-family balance decisions of professional parents
Research on work-family balance decisions generally presents them as an individual’s rational choice between alternatives. The anticipatory socialisation literature highlights the role that early formative experiences play in shaping work and parenting decisions. We go further to emphasise the role of habitus – historically constituted dispositions – in the work-family balance decisions. This relational approach explores how the entrenched and historically formed dispositions of individuals interact dynamically with contextual (i.e. organizational) imperatives. Numerous studies have highlighted the difficulties of reconciling the intense demands of professional careers with family lives. Drawing on 148 interviews with 78 male and female professionals, our study looks at much deeper rooted causes of work-family conflict in professional service firms than have previously been considered. We identify four broad patterns of response to the work-family conflict: professionals may willingly reproduce their parental model, reproduce their parental model against their will, willingly distance themselves from their parental model, and distance themselves from the parental model against their will. We show that the impediments to greater equality lie not only in organizational and societal structures, but within individuals themselves in the form of historically constituted dispositions which contribute towards the maintenance and reproduction of those structures
The role of expertise in dynamic risk assessment: A reflection of the problem-solving strategies used by experienced fireground commanders
Although the concept of dynamic risk assessment has in recent times become more topical in the training manuals of most high risk domains, only a few empirical studies have reported how experts actually carry out this crucial task. The knowledge gap between research and practice in this area therefore calls for more empirical investigation within the naturalistic environment. In this paper, we present and discuss the problem solving strategies employed by sixteen experienced operational firefighters using a qualitative knowledge elicitation tool — the critical decision method. Findings revealed that dynamic risk assessment is not merely a process of weighing the risks of a proposed course of action against its benefits, but rather an experiential and pattern recognition process. The paper concludes by discussing the implications of designing training curriculum for the less experienced officers using the elicited expert knowledge
Unveiling professional development: A critical review of stage models
In research across professions, the development of professional skill traditionally was seen as a process of accumulation of knowledge and skills, promoted by practical experience. More recently, this view has been modified to incorporate skillful know-how that is progressively acquired by passing through developmental stages, such as novice, competent, and expert. The authors of this article critically review contemporary stage models that are typically applied across professions. Their principal critique is that a focus on stages veils or conceals more fundamental aspects of professional skill development. On the basis of their critique, the authors propose an alternative model that builds on the strengths of previous models while seeking to overcome their main limitations. Finally, the authors outline the implications of their alternative model for professional education, workplace practices, and research on professional development
Understanding atmospheric organic aerosols via factor analysis of aerosol mass spectrometry: a review
Organic species are an important but poorly characterized constituent of airborne particulate matter. A quantitative understanding of the organic fraction of particles (organic aerosol, OA) is necessary to reduce some of the largest uncertainties that confound the assessment of the radiative forcing of climate and air quality management policies. In recent years, aerosol mass spectrometry has been increasingly relied upon for highly time-resolved characterization of OA chemistry and for elucidation of aerosol sources and lifecycle processes. Aerodyne aerosol mass spectrometers (AMS) are particularly widely used, because of their ability to quantitatively characterize the size-resolved composition of submicron particles (PM1). AMS report the bulk composition and temporal variations of OA in the form of ensemble mass spectra (MS) acquired over short time intervals. Because each MS represents the linear superposition of the spectra of individual components weighed by their concentrations, multivariate factor analysis of the MS matrix has proved effective at retrieving OA factors that offer a quantitative and simplified description of the thousands of individual organic species. The sum of the factors accounts for nearly 100% of the OA mass and each individual factor typically corresponds to a large group of OA constituents with similar chemical composition and temporal behavior that are characteristic of different sources and/or atmospheric processes. The application of this technique in aerosol mass spectrometry has grown rapidly in the last six years. Here we review multivariate factor analysis techniques applied to AMS and other aerosol mass spectrometers, and summarize key findings from field observations. Results that provide valuable information about aerosol sources and, in particular, secondary OA evolution on regional and global scales are highlighted. Advanced methods, for example a-priori constraints on factor mass spectra and the application of factor analysis to combined aerosol and gas phase data are discussed. Integrated analysis of worldwide OA factors is used to present a holistic regional and global description of OA. Finally, different ways in which OA factors can constrain global and regional models are discussed
Enforced Expression of the Transcriptional Coactivator OBF1 Impairs B Cell Differentiation at the Earliest Stage of Development
OBF1, also known as Bob.1 or OCA-B, is a B lymphocyte-specific transcription factor which coactivates Oct1 and Oct2 on B cell specific promoters. So far, the function of OBF1 has been mainly identified in late stage B cell populations. The central defect of OBF1 deficient mice is a severely reduced immune response to T cell-dependent antigens and a lack of germinal center formation in the spleen. Relatively little is known about a potential function of OBF1 in developing B cells. Here we have generated transgenic mice overexpressing OBF1 in B cells under the control of the immunoglobulin heavy chain promoter and enhancer. Surprisingly, these mice have greatly reduced numbers of follicular B cells in the periphery and have a compromised immune response. Furthermore, B cell differentiation is impaired at an early stage in the bone marrow: a first block is observed during B cell commitment and a second differentiation block is seen at the large preB2 cell stage. The cells that succeed to escape the block and to differentiate into mature B cells have post-translationally downregulated the expression of transgene, indicating that expression of OBF1 beyond the normal level early in B cell development is deleterious. Transcriptome analysis identified genes deregulated in these mice and Id2 and Id3, two known negative regulators of B cell differentiation, were found to be upregulated in the EPLM and preB cells of the transgenic mice. Furthermore, the Id2 and Id3 promoters contain octamer-like sites, to which OBF1 can bind. These results provide evidence that tight regulation of OBF1 expression in early B cells is essential to allow efficient B lymphocyte differentiation
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NMR-based metabolic characterization of chicken tissues and biofluids: a model for avian research
Introduction
Poultry is one of the most consumed meat in the world and its related industry is always looking for ways to improve animal welfare and productivity. It is therefore essential to understand the metabolic response of the chicken to new feed formulas, various supplements, infections and treatments.
Objectives
As a basis for future research investigating the impact of diet and infections on chicken’s metabolism, we established a high-resolution proton nuclear magnetic resonance (NMR)-based metabolic atlas of the healthy chicken (Gallus gallus).
Methods
Metabolic extractions were performed prior to 1H-NMR and 2D NMR spectra acquisition on twelve biological matrices: liver, kidney, spleen, plasma, egg yolk and white, colon, caecum, faecal water, ileum, pectoral muscle and brain of 6 chickens. Metabolic profiles were then exhaustively characterized.
Results
Nearly 80 metabolites were identified. A cross-comparison of these matrices was performed to determine metabolic variations between and within each section and highlighted that only eight core metabolites were systematically found in every matrice.
Conclusion
This work constitutes a database for future NMR-based metabolomic investigations in relation to avian production and health
Emotional Engineers: Toward Morally Responsible Design
Engineers are normally seen as the archetype of people who make decisions in a rational and quantitative way. However, technological design is not value neutral. The way a technology is designed determines its possibilities, which can, for better or for worse, have consequences for human wellbeing. This leads various scholars to the claim that engineers should explicitly take into account ethical considerations. They are at the cradle of new technological developments and can thereby influence the possible risks and benefits more directly than anybody else. I have argued elsewhere that emotions are an indispensable source of ethical insight into ethical aspects of risk. In this paper I will argue that this means that engineers should also include emotional reflection into their work. This requires a new understanding of the competencies of engineers: they should not be unemotional calculators; quite the opposite, they should work to cultivate their moral emotions and sensitivity, in order to be engaged in morally responsible engineering
Epistemic Constraints on Autonomous Symbolic Representation in Natural and Artificial Agents
We set out to address, in the form of a survey, the fundamental constraints upon self-updating representation in cognitive agents of natural and artificial origin. The foundational epistemic problem encountered by such agents is that of distinguishing errors of representation from inappropriateness of the representational framework. Resolving this conceptual difficulty involves ensuring the empirical falsifiability of both the representational hypotheses and the entities so represented, while at the same time retaining their epistemic distinguishability. We shall thus argue that perception-action frameworks provide an appropriate basis for the development of an empirically meaningful criterion for validating perceptual categories. In this scenario, hypotheses about the agent’s world are defined in terms of environmental affordances (characterised in terms of the agent’s active capabilities). Agents with the capability to hierarchically-abstract this framework to a level consonant with performing syntactic manipulations and making deductive conjectures are consequently able to form an implicitly symbolic representation of the environment within which new, higher-level, modes of environment manipulation are implied (e.g. tool-use). This abstraction process is inherently open-ended, admitting a wide-range of possible representational hypotheses — only the form of the lowest-level of the hierarchy need be constrained a priori (being the minimally sufficient condition necessary for retention of the ability to falsify high-level hypotheses). In biological agents capable of autonomous cognitive-updating, we argue that the grounding of such a priori ‘bootstrap’ representational hypotheses is ensured via the process of natural selection
‘Curiouser and curiouser!’:organizations as wonderland – a metaphorical alternative to the rational model
The metaphors in Morgan’s (1986) Images of Organization largely imply order, rationality, stability and manageability. This reflects that the text is concerned with facilitating the design and management of organizations. This article draws on Lewis Carroll’s (1865) novel Alice’s Adventures in Wonderland to propose Wonderland as an alternative metaphor that places at centre stage issues such as absurdity, irrationality, uncertainty and disorder. Rather than a marginal or temporary aberration, it is argued that such conditions need to be understood as an everyday experience for many. This metaphor is important because those who are tasked with managing organizations may find it stressful and puzzling that they are so inept, when they compare their experiences and achievements with the rational model. In this sense, it offers both comfort and perhaps encouragement, but it should also foster humility and caution in terms of what those at the top can achieve. Likewise, those on the receiving end of irrational decisions or who reside in absurd worlds can gain solace from knowing that they are not alone, whilst those concerned with resisting such conditions can find strength in the knowledge that those in positions of authority are not omniscient/omnipotent
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