Cousins Photometry and Temperatures for the Hyades, Coma, NGC 752, Praesepe, and M67

In this paper, new Cousins VRI data are presented for NGC 752 and Praesepe, and new and extant data are combined into an augmented database for M67. For those three clusters, catalogs containing Cousins VRI photometry, reddening-corrected values of (V -K)(J), and temperatures are produced. The same is done for Coma by using both previously published and newly derived Cousins photometry. An extant set of catalogs for the Hyades is updated to include V magnitudes and values of (R -I)(C) that were published after the original catalogs appeared. Finally, M67 V magnitudes published previously by Sandquist are corrected for an effect that depends on location on the face of the cluster. The corrected data and values of (V -I)(C) given by Sandquist are then set out in a supplementary catalog. Data files containing all of these catalogs are deposited in the CDS archives. To assess the quality of the data in the catalogs, the consistency of extant Cousins VRI databases is tested by performing analyses with the following features: (1) quantities as small as a few millimags are regarded as meaningful; (2) statistical analysis is applied; (3) no use is made of data other than VRI measurements and comparable results; (4) no inferences are drawn from color-magnitude comparisons; (5) pertinent data that have not been included previously are analyzed; and (6) results based on direct comparisons of stellar groups at the telescope are featured. In this way, it is found that our updated M67 color data and those of Sandquist are on the E region zero point. In contrast, values of (V -I)(C) from Montgomery and collaborators are found to be too red by 27 +/- 3 mmag, with an even larger offset being likely for unpublished data from Richer and his collaborators. Zero-point tests of our Cousins VRI colors for Coma, Praesepe, and NGC 752 are also satisfactory. Scale factor tests of the M67 colors are performed, and a likely scale factor error in the Montgomery et al. colors is found. However, it appears at present that the scale factors of our M67 colors and those of Sandquist are satisfactory. For the most part, zero-point tests of the assembled V magnitudes are also satisfactory, although it is found that further work on the V magnitudes for Praesepe and M67 would be useful. To put these results in perspective, it is pointed out that photometric tests that are satisfactory at the few-millimag level have been published for some two decades and so are not appearing for the first time in this paper.Astronom

Medical Implications of Space Radiation Exposure Due to Low Altitude Polar Orbits

Space radiation research has progressed rapidly in recent years, but there remain large uncertainties in predicting and extrapolating biological responses to humans. Exposure to cosmic radiation and Solar Particle Events may pose a critical health risk to future spaceflight crews and can have a serious impact to all biomedical aspects of space exploration. The relatively minimal shielding of the cancelled 1960's Manned Orbiting Laboratory program's space vehicle and the high inclination polar orbits would have left the crew susceptible to high exposures of cosmic radiation and high dose-rate SPEs that are mostly unpredictable in frequency and intensity. In this study, we have modeled the nominal and off-nominal radiation environment that a MOL-like spacecraft vehicle would be exposed to during a 30-day mission using high performance, multi-core computers. Projected doses from a historically large SPE (e.g. the August 1972 solar event) have been analyzed in the context of the MOL orbit profile, providing an opportunity to study its impact to crew health and subsequent contingencies.It is reasonable to presume that future commercial, government, and military spaceflight missions in low-Earth orbit will have vehicles with similar shielding and orbital profiles. Studying the impact of cosmic radiation to the mission's operational integrity and the health of MOL crewmembers provides an excellent surrogate and case-study for future commercial and military spaceflight missions.Comment: 6 pages, 4 figures, 2 table

Estimating Peak Demand for Beach Parking Spaces

The United States Army Corps of Engineers planning guidance stipulates that in order for local beach communities to qualify for Federal cost share funds for Hurricane and Storm Damage Reduction beach renourishment projects, the community must provide public beach access and parking to satisfy peak demand. This study presents a method for estimating peak demand for beach parking spaces in the presence of parking constraints. A Tobit regression model is developed to estimate the number of parking spaces that would be necessary to meet unconstrained demand on a given percentage of peak demand days. For example, the model can be used to estimate the number of parking spaces that would be adequate to meet peak demand on 90% of peak parking days. The Tobit model provides a promising framework for estimating peak parking demand under constrained parking conditions, a situation that characterizes most beach communities.

Possible Stellar Metallicity Enhancements from the Accretion of Planets

A number of recently discovered extrasolar planet candidates have surprisingly small orbits, which may indicate that considerable orbital migration takes place in protoplanetary systems. A natural consequence of orbital migration is for a series of planets to be accreted, destroyed, and then thoroughly mixed into the convective envelope of the central star. We study the ramifications of planet accretion for the final main sequence metallicity of the star. If maximum disk lifetimes are on the order of 10 Myr, stars with masses near 1 solar mass are predicted to have virtually no metallicity enhancement. On the other hand, early F and late A type stars with masses of 1.5--2.0 solar masses can experience significant metallicity enhancements due to their considerably smaller convection zones during the first 10 Myr of pre-main-sequence evolution. We show that the metallicities of an aggregate of unevolved F stars are consistent with an average star accreting about 2 Jupiter-mass planets from a protoplanetary disk having a 10 Myr dispersal time.Comment: 14 pages, AAS LaTeX, 3 figures, accepted to ApJ Letter

Inhibition of vascular endothelial growth factor with a sequence-specific hypoxia response element antagonist

Vascular endothelial growth factor (VEGF) and its receptors have been implicated as key factors in tumor angiogenesis that are up-regulated by hypoxia. We evaluated the effects of DNA-binding small molecules on hypoxia-inducible transcription of VEGF. A synthetic pyrrole-imidazole polyamide designed to bind the hypoxia response element (HRE) was found to disrupt hypoxia-inducible factor (HIF) binding to HIRE. In cultured HeLa cells, this resulted in a reduction of VEGF mRNA and secreted protein levels. The observed effects were polyamide-specific and dose-dependent. Analysis of genome-wide effects of the HIRE-specific polyamide revealed that a number of hypoxia-inducible genes were down-regulated. Pathway-based regulation of hypoxia-inducible gene expression with DNA-binding small molecules may represent a new approach for targeting angiogenesis

Setting and motivation in the decision to participate: An approach to the engagement of diverse samples in mobile research.

Internet and mobile based research are powerful tools in the creation of large, cohort studies (eCohort). However, recent analysis indicates that an underrepresentation of minority and low income groups in these studies might exceed that found in traditional research [1-5]. In this report, we present findings from an experiment in research engagement using the Eureka Research Platform developed to enroll diverse populations in support of biomedical clinical research. This experiment involved the recruitment of African American and Latino participants in a smartphone based survey at a temporary, charitable, dental event sponsored, in part, by the research team, in order to explore the impact of setting and approach on recruitment outcomes. 211 participants enrolled including a significant representation of African Americans (51%) and Latinos (31%) and those with education levels at high school or less (37%). Interviews conducted after the study confirmed that our recruitment efforts within the context of a service event affected the decision to participate. While further research is necessary, this experiment holds promise for the engagement of underrepresented groups in research

Improving Mitochondrial Function Protects Bumblebees from Neonicotinoid Pesticides

Global pollination is threatened by declining insect pollinator populations that may be linked to neonicotinoid pesticide use. Neonicotinoids over stimulate neurons and depolarize their mitochondria, producing immobility and death. However, mitochondrial function can be improved by near infrared light absorbed by cytochrome c oxidase in mitochondrial respiration. In flies, daily exposure to 670nm light throughout life increases average lifespan and aged mobility, and reduces systemic inflammation. Here we treat bumble bees with Imidacloprid a common neonicotinoid. This undermined ATP and rapidly induced immobility and reduced visual function and survival. Bees exposed to insecticide and daily to 670nm light showed corrected ATP levels and significantly improved mobility allowing them to feed. Physiological recordings from eyes revealed that light exposure corrected deficits induced by the pesticide. Overall, death rates in bees exposed to insecticide but also given 670nm light were indistinguishable from controls. When Imidacloprid and light exposure were withdrawn, survival was maintained. Bees and insects generally cannot see deep red light so it does not disturb their behaviour. Hence, we show that deep red light exposure that improves mitochondrial function, reverses the sensory and motor deficits induced by Imidacloprid. These results may have important implications as light delivery is economic and can be placed in hives/colonies

The molecular basis of host specialization in bean pathovars of Pseudomonas syringae

Biotrophic phytopathogens are typically limited to their adapted host range. In recent decades, investigations have teased apart the general molecular basis of intraspecific variation for innate immunity of plants, typically involving receptor proteins that enable perception of pathogen-associated molecular patterns or avirulence elicitors from the pathogen as triggers for defense induction. However, general consensus concerning evolutionary and molecular factors that alter host range across closely related phytopathogen isolates has been more elusive. Here, through genome comparisons and genetic manipulations, we investigate the underlying mechanisms that structure host range across closely related strains of Pseudomonas syringae isolated from different legume hosts. Although type III secretionindependent virulence factors are conserved across these three strains, we find that the presence of two genes encoding type III effectors (hopC1 and hopM1) and the absence of another (avrB2) potentially contribute to host range differences between pathovars glycinea and phaseolicola. These findings reinforce the idea that a complex genetic basis underlies host range evolution in plant pathogens. This complexity is present even in host–microbe interactions featuring relatively little divergence among both hosts and their adapted pathogens

Structured computer-based training in the interpretation of neuroradiological images

Computer-based systems may be able to address a recognised need throughout the medical profession for a more structured approach to training. We describe a combined training system for neuroradiology, the MR Tutor that differs from previous approaches to computer-assisted training in radiology in that it provides case-based tuition whereby the system and user communicate in terms of a well-founded Image Description Language. The system implements a novel method of visualisation and interaction with a library of fully described cases utilising statistical models of similarity, typicality and disease categorisation of cases. We describe the rationale, knowledge representation and design of the system, and provide a formative evaluation of its usability and effectiveness

Pro-inflammatory flagellin proteins of prevalent motile commensal bacteria are variably abundant in the intestinal microbiome of elderly humans

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