12 research outputs found
Human malarial disease: a consequence of inflammatory cytokine release
- Author
- A Bouchama
- A Kovelenov
- A Kumar
- A Maran
- A Nissan
- A Rahbar
- A Rouhiainen
- A Schurr
- A Sheikha
- A Takeda
- AC Koong
- AC Windsor
- AD Michelson
- AH Span
- AJ Luty
- AL Graham
- AL Suguitan
- Alison C Budd
- AM Dondorp
- AM Dondorp
- AM Dondorp
- AM Dondorp
- AM Donoghue
- AV Hill
- B Beutler
- B Beutler
- B Franke-Fayard
- B Genton
- B Levy
- B Maegraith
- B Maegraith
- BB Aggarwal
- BC Kone
- BG Maegraith
- BG Yipp
- BH Kean
- BH Kean
- BK Lopansri
- BR Bloom
- BS Cain
- C Fiuza
- C Golgi
- C Ince
- C Krishnamurti
- C Luxemburger
- C Mecher
- C Newbold
- C Othoro
- C Shindoh
- C Szabo
- C Wenisch
- CA Bate
- CA Dinarello
- CAW Bate
- CC Keller
- CC Lee
- CC Mabry
- CJ Fisher
- CL Sprung
- CM Calkins
- CO Enwonwu
- CS Boutlis
- CT Esmon
- CT Esmon
- CY Cheung
- D Annane
- D Anrather
- D Brealey
- D Brealey
- D Dodoo
- D Duma
- D Kwiatkowski
- D Mohanty
- D Yoshinari
- DA Jacobsohn
- DA Svistunenko
- DA Warrell
- DB Wilson
- DC Gore
- DG Davis
- DI Thurnham
- DJ Perkins
- DJ Pombo
- DJ White
- DK Kochar
- DR Spriggs
- DR Spriggs
- E Dekker
- E L'Her
- E Marchiafava
- EA Carswell
- EC Dell'Angelica
- ED Crouser
- EL Bell
- ET Creagan
- F Bauss
- F Benigni
- F Chagnon
- F Marra
- F Plum
- F Rogers
- F Rosner
- FA Husain
- FB Cerra
- FEG Cox
- G Azimi
- G Gutierrez
- G Kaplanski
- G Wambach
- GA Butcher
- GA Butcher
- GE Grau
- GG MacPherson
- GS Supinski
- H Beigel
- H Illner
- H Ishii
- H Kan
- H Kawashima
- H Morita
- H Ogura
- H Tsukahara
- HA Giha
- HA Krebs
- HC Clark
- HC Wang
- HE Meleney
- HJ ter Hofstede
- HY Lan
- I Clark
- IA Clark
- IA Clark
- IA Clark
- IA Clark
- IA Clark
- IA Clark
- IA Clark
- IA Clark
- IA Clark
- IA Clark
- IA Clark
- IA Clark
- IA Clark
- IA Clark
- IA Clark
- IA Clark
- IA Clark
- IA Clark
- IA Clark
- IA Clark
- IA Clark
- Ian A Clark
- IM Medana
- J Arii
- J Baudier
- J Boczkowski
- J Boczkowski
- J Crawley
- J David
- J Langhorne
- J Levraut
- J May
- J Takezawa
- J Taverne
- J Taverne
- JA Carcillo
- JA Martiney
- JA Watts
- JB Molloy
- JC Hatcher
- JC Knight
- JD Eason
- JE Aiyathurai
- JG Prudhomme
- JH Distler
- JH van Zeijl
- JK Patnaik
- JM Freyssinet
- JM Gleadle
- JP Maciejewski
- JP Mira
- JP Revelly
- K Abeyama
- K Bendtzen
- K Kunze
- K Maitland
- K Maitland
- K Maitland
- K Marsh
- K Marsh
- K Marsh
- K Mikawa
- K Pellegrin
- KA Barsness
- KA Barsness
- KA Rockett
- KA Rockett
- KB Sandau
- KB Seydel
- KL Miller
- KN Mendis
- KS Rowin
- L Pellerin
- L Schofield
- L Schofield
- L Schofield
- L Schofield
- L Ulloa
- L Weiss
- LA Callahan
- LA Callahan
- LA Callahan
- LC Lopez
- LH Miller
- Lisa M Alleva
- LL Mantell
- LM Alleva
- M Aidoo
- M English
- M English
- M English
- M English
- M Feldmann
- M Fink
- M Gawaz
- M Helleberg
- M Holecek
- M Hosoya
- M Hosoya
- M Levi
- M Odeh
- M Rug
- M Scharte
- M Schweizer
- M Treacy
- MA Beg
- MA McDevitt
- MB Van Hensbroek
- MC Papadopoulos
- ME Molyneux
- ME Molyneux
- MF Good
- MF Shaio
- MG O'Sullivan
- MI Muniz-Junqueira
- MJ Dunn
- MP Fink
- MP Heyes
- MS Bajaj
- MV Lee
- MV Riley
- N Adachi
- N Balasubramanyan
- N Carbo
- N Clavier
- N Pathan
- N Stocchetti
- ND Karunaweera
- ND Karunaweera
- NJ Guzman
- NJ White
- NJ White
- NM Anstey
- NM Anstey
- NP Day
- O Court
- P Boekstegers
- P Dörmer
- P Kern
- P King
- P Mitchell
- P Ringwald
- P Sasi
- P Scaffidi
- P Wolf
- PF Piguet
- PL Lu
- PM Parizel
- PR Cannon
- PW Stacpoole
- R Kokkola
- R Lauterbach
- R Nieuwland
- R Ross
- R Ubalee
- RA Kreisberg
- RA Patchell
- RA Reid
- RC Bone
- RE Phillips
- RM Bateman
- RM Coleman
- RR Overmann
- RS Bray
- RS Hotchkiss
- S Adams
- S Ehrhardt
- S Ehrhardt
- S Endo
- S Issifou
- S Jayavanth
- S Krishna
- S Krishna
- S Krishna
- S Lanone
- S Lanone
- S Nadel
- S Russwurm
- S Sassa
- S Yokota
- SA Deshpande
- SC Chaiyaroj
- SC Dennis
- SC Wassmer
- SI Miller
- SJ Rogerson
- SJ Rogerson
- SJ Rogerson
- SJ Rogerson
- SL Carpenter
- SL Wangensteen
- SN Wickramasinghe
- SN Wickramasinghe
- T Calandra
- T Calandra
- T Calandra
- T Calandra
- T Calandra
- T Calandra
- T Hellwig-Burgel
- T Ichiyama
- T Ichiyama
- T Imamura
- T Morishima
- T Planche
- T Planche
- T Planche
- T Planche
- T Planche
- T Planche
- T Srichaikul
- T Tatsumi
- T Taylor
- T Togashi
- TC Hurd
- TE Taylor
- TE Taylor
- TJ Van der Meer
- TR Ulich
- U Andersson
- V Combes
- V Combes
- V Combes
- V Delley
- V Eggers
- W Graninger
- WH Taliaferro
- William B Cowden
- XC Lin
- XM Xie
- Y Nakai
- YL Yang
- YM Yao
- YW Xie
- YY Li
- Z Gunduz
- Z Herceg
- Publication venue
- BioMed Central
- Publication date
- 01/01/2006
- Field of study
Malaria causes an acute systemic human disease that bears many similarities, both clinically and mechanistically, to those caused by bacteria, rickettsia, and viruses. Over the past few decades, a literature has emerged that argues for most of the pathology seen in all of these infectious diseases being explained by activation of the inflammatory system, with the balance between the pro and anti-inflammatory cytokines being tipped towards the onset of systemic inflammation. Although not often expressed in energy terms, there is, when reduced to biochemical essentials, wide agreement that infection with falciparum malaria is often fatal because mitochondria are unable to generate enough ATP to maintain normal cellular function. Most, however, would contend that this largely occurs because sequestered parasitized red cells prevent sufficient oxygen getting to where it is needed. This review considers the evidence that an equally or more important way ATP deficency arises in malaria, as well as these other infectious diseases, is an inability of mitochondria, through the effects of inflammatory cytokines on their function, to utilise available oxygen. This activity of these cytokines, plus their capacity to control the pathways through which oxygen supply to mitochondria are restricted (particularly through directing sequestration and driving anaemia), combine to make falciparum malaria primarily an inflammatory cytokine-driven disease
Multi-messenger observations of a binary neutron star merger
- Author
- Aab A
- Aartsen MG
- Abbott BP
- Abbott R
- Abbott TD
- Abbott TMC
- Abdalla H
- Abe F
- Abeysekara AU
- Abramo LR
- Abramowski A
- Abreu P
- Acernese F
- Acero F
- Ackermann M
- Ackley K
- Ackley K
- Adams C
- Adams J
- Adams SM
- Adams T
- Addesso P
- Adhikari RX
- Adya VB
- Affeldt C
- Afrough M
- Agarwal B
- Agathos M
- Agatsuma K
- Aggarwal N
- Aglietta M
- Agliozzo C
- Agudo I
- Aguiar OD
- Aguilar JA
- Aharonian F
- Ahlers M
- Ahrens M
- Aiello L
- Ain A
- Ajith P
- Akras S
- Al Samarai I
- Albert A
- Albert A
- Albuquerque IFM
- Albury JM
- Alcaniz JS
- Alexander KD
- Alfaro R
- Alighieri S Di Serego
- Allam S
- Allekotte I
- Allen B
- Allen G
- Allison J
- Allison JR
- Allocca A
- Almela A
- Altin PA
- Altmann D
- Alvarez C
- Alvarez JD
- Alvarez M Dovale
- Alvarez-Muiz J
- Amati L
- Amato A
- An T
- Ananyeva A
- Anastasi GA
- Anchordoqui L
- Andeen K
- Anderson JP
- Anderson SB
- Anderson T
- Anderson WG
- Andrada B
- Andre M
- Andreoni I
- Andreoni I
- Andringa S
- Angelova SV
- Anghinolfi M
- Angner EO
- Angus CR
- Annis J
- Ansseau I
- Antier S
- Anton G
- Antonelli LA
- Antonelli LA
- Anupama GC
- Aoki K
- Aoki W
- Appert S
- Aptekar RL
- Arai K
- Arakawa M
- Aramo C
- Araya MC
- Arcavi I
- Arceo R
- Ardid M
- Areeda JS
- Aresu G
- Argan A
- Argelles C
- Arnaud N
- Array LWA Long Wavelength
- Array MWA Murchison Widefield
- Arrieta M
- Arsene N
- Arteaga-Velzquez JC
- Artola R
- Arun KG
- Asakura Y
- Asaoka Y
- Ascenzi S
- Ashall C
- Ashley MCB
- Ashton G
- Asorey H
- Assis P
- Ast M
- Aston SM
- Astone P
- Atallah DV
- ATLAS
- Atwood WB
- Aubert J-J
- Aubert P
- Aublin J
- Auffenberg J
- Aufmuth P
- Aulbert C
- AultONeal K
- Austin C
- Avgitas T
- Avila G
- Avila-Alvarez A
- Awad A Kuotb
- Axani S
- Baar S
- Babak S
- Bachetti M
- Backes M
- Bacon P
- Bader MKM
- Badescu AM
- Bae S
- Bagherpour H
- Bai X
- Bailes M
- Baker PT
- Balaceanu A
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- Balasubramanian A
- Balbinot E
- Baldaccini F
- Baldini L
- Ballardin G
- Ballmer SW
- Bally J
- Balzer A
- Banagiri S
- Banerji M
- Bannister KW
- Barayoga JC
- Barbarino C
- Barbato F
- Barber AS
- Barbiellini G
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- Barish BC
- Barker D
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- Bchele M
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- Becerril A
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- Beer C
- Bejger M
- Belahcene I
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- Bellazzini R
- Bellido JA
- Bellm E
- Belmont-Moreno E
- Benetti S
- Benkhali F Ait
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- Berenji B
- Berge D
- Berger BK
- Berger E
- Bergmann G
- Berisso M Gomez
- Berley D
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- Bernhard S
- Bernrhr K
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- Beroiz M
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- Bersanetti D
- Bertaina ME
- Bertin E
- Bertin V
- Bertolini A
- Berton M
- Bertou X
- Bessell MS
- Besson DZ
- Beswick R
- Betzwieser J
- Bhagwat S
- Bhalerao V
- Bhandare R
- Bhattacharya D
- Biagi S
- Biermann PL
- Bilenko IA
- Billingsley G
- Billman CR
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- Bisht A
- Bissaldi E
- Bissaldi E
- Biteau J
- Bitossi M
- Biwer C
- Bizouard MA
- Blackburn JK
- Blackburn L
- Blackman J
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- Blazek J
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- Bloom ED
- Blot S
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- Bohacova M
- Bohe A
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- Bolmont J
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- Bonnand R
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- Bonoli S
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- Botticella MT
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- Caccianiga L
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- CALTECH GROWTH JAGWAR
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- de Oliveira C Mendes
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- De Palma F
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- Observat Toros Transient Robotic
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- Palamos JR
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- Paliya VS
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- Palmerio JT
- Palmese A
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- Pan Howard
- Pan Huang-Wei
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- Pan-STARRS
- Pandey SB
- Pandya H
- Paneque D
- Pang B
- Pang PTH
- Pankova DV
- Pankow C
- Pannarale F
- Pant BC
- Panter M
- Paoletti F
- Paoletti F
- Paoli A
- Papa MA
- Papenbreer P
- Paragi Z
- Parente G
- Parida A
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- Parmiggiani N
- Parra A
- Parsons RD
- Pascucci D
- Pasqualetti A
- Passaquieti R
- Passuello D
- Pastorello A
- Patat F
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- Pavalas GE
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- Pearlstone BL
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- Peixoto CJ Todero
- Pekeur NW
- Pekowsky L
- Pelayo R
- Pele A
- Pellegrino C
- Pelletier G
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- Penn S
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- Piccinni OJ
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- Piel Q
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- Piergiovanni F
- Pierog T
- Pierro V
- Pignata G
- Pike S
- Pilia M
- Pillant G
- Pimenta M
- Pinard L
- Pinat E
- Pinto IM
- Piotrowski LW
- Piran T
- Piran T
- Piranomonte S
- Pirello M
- Piro AL
- Piro L
- Piron F
- Pirronello V
- Pisanu T
- Pita S
- Pitkin M
- Pittori C
- Placco VM
- Platino M
- Plazas AA
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- Podesta RC
- Podsiadlowski P
- Poe M
- Poggiani R
- Poh J
- Poireau V
- Pollmann A Obertacke
- Poolakkil S
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- Popolizio P
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- Porter EK
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- Possenti A
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- Pozanenko AS
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- Prado RR
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- Principe G
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- Prodi GA
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- Prokhorov LG
- Prokoph H
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- Przybylski GT
- Pulone L
- Pumo ML
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- Querel R
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- Quimby RM
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- Reimer A
- Reimer O
- Reimer O
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- Relethford B
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- Ren W
- Ren Z
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- Renzi V
- Reposeur T
- Resconi E
- Resmi L
- Rest A
- Reva IV
- Reyes R De Los
- Reyes SD
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- Riviere C
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- Rodriguez H
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- Rosell A Carnero
- Rosenberg M
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- Rosswog S
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- Rulten CB
- Rumyantsev VV
- Rusu F
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- Sadler EM
- Sadler EM
- Saffe C
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- Sahakian V
- Sai N
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- Sakamaki A
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- Sakellariadou M
- Sako M
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- Salamida F
- Salazar H
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- Saleem M
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- Salemi F
- Salina G
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- Salvadori I
- Salvaterra R
- Samajdar A
- Sammut L
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- Samtleben DFE
- Sanchez B
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- Sanchez LE
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- Schroder FG
- Schroder S
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- Schwanke U
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- Sciutto SJ
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- Segreto A
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- Seitenzahl IR
- Sekiguchi Y
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- Shang Z
- Shannon RM
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- Sharp RG
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- Shimomukai R
- Shingles LJ
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- Shoemaker DH
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- Siebert MR
- Siegel MH
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- Siemens X
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- Sinnis G
- Sintes AM
- Siskind EJ
- Slagmolen BJJ
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- Smida R
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- Smith KW
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- Srivastava AK
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- Starck M
- Starling RLC
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- Stone R
- Stops DJ
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- Strafella F
- Strain KA
- Stratta G
- Streich A
- Strigin SE
- Strotjohann NL
- Strunk A
- Stubbs CW
- Sturani R
- Stuttard T
- Stuver AL
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- Suchyta E
- Sudholz T
- Sugawara Y
- Sugita S
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- Sullivan GW
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- Sumi T
- Summerscales TZ
- Sun L
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- Sunyaev R
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- Supanitsky AD
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- Taboada I
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- Tao C
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- Tenholt F
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- Terrier R
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- Testa V
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- Tuo YL
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- Turley CF
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- Tyurina NV
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- Ulrich R
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- Publication venue
- 'American Astronomical Society'
- Publication date
- 01/01/2017
- Field of study
On 2017 August 17 a binary neutron star coalescence candidate (later designated GW170817) with merger time 12:41:04 UTC was observed through gravitational waves by the Advanced LIGO and Advanced Virgo detectors. The Fermi Gamma-ray Burst Monitor independently detected a gamma-ray burst (GRB 170817A) with a time delay of ~1.7 s with respect to the merger time. From the gravitational-wave signal, the source was initially localized to a sky region of 31 deg2 at a luminosity distance of 40+8-8 Mpc and with component masses consistent with neutron stars. The component masses were later measured to be in the range 0.86 to 2.26 Mo. An extensive observing campaign was launched across the electromagnetic spectrum leading to the discovery of a bright optical transient (SSS17a, now with the IAU identification of AT 2017gfo) in NGC 4993 (at ~40 Mpc) less than 11 hours after the merger by the One- Meter, Two Hemisphere (1M2H) team using the 1 m Swope Telescope. The optical transient was independently detected by multiple teams within an hour. Subsequent observations targeted the object and its environment. Early ultraviolet observations revealed a blue transient that faded within 48 hours. Optical and infrared observations showed a redward evolution over ~10 days. Following early non-detections, X-ray and radio emission were discovered at the transient’s position ~9 and ~16 days, respectively, after the merger. Both the X-ray and radio emission likely arise from a physical process that is distinct from the one that generates the UV/optical/near-infrared emission. No ultra-high-energy gamma-rays and no neutrino candidates consistent with the source were found in follow-up searches. These observations support the hypothesis that GW170817 was produced by the merger of two neutron stars in NGC4993 followed by a short gamma-ray burst (GRB 170817A) and a kilonova/macronova powered by the radioactive decay of r-process nuclei synthesized in the ejecta
Evaluation of appendicitis risk prediction models in adults with suspected appendicitis
- Author
- Abbas Sh
- Abbas Sh
- Abbassi Oa
- Abbott T
- Abdelgadir Am
- Abdelrahman A
- Abdelrahman M
- Abdelrahman M
- Abdelwahed A
- Abellan M
- Abellán Am
- Abellán Am
- Abulafi M
- Acharya A
- Acosta A
- Adam Me
- Adams Re
- Adegbola So
- Adegbola So
- Adimonye A
- Adnan M
- Afshar S
- Agresta F
- Agua Ia
- Aguayo Jl
- Agudo Ar
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- Ahel J
- Ahern Dp
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- Ahmed G
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- Zhang Ay
- Zhou S
- Zorrilla L
- Zuin M
- Zurleni Tz
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2019
- Field of study
Background
Appendicitis is the most common general surgical emergency worldwide, but its diagnosis remains challenging. The aim of this study was to determine whether existing risk prediction models can reliably identify patients presenting to hospital in the UK with acute right iliac fossa (RIF) pain who are at low risk of appendicitis.
Methods
A systematic search was completed to identify all existing appendicitis risk prediction models. Models were validated using UK data from an international prospective cohort study that captured consecutive patients aged 16–45 years presenting to hospital with acute RIF in March to June 2017. The main outcome was best achievable model specificity (proportion of patients who did not have appendicitis correctly classified as low risk) whilst maintaining a failure rate below 5 per cent (proportion of patients identified as low risk who actually had appendicitis).
Results
Some 5345 patients across 154 UK hospitals were identified, of which two‐thirds (3613 of 5345, 67·6 per cent) were women. Women were more than twice as likely to undergo surgery with removal of a histologically normal appendix (272 of 964, 28·2 per cent) than men (120 of 993, 12·1 per cent) (relative risk 2·33, 95 per cent c.i. 1·92 to 2·84; P < 0·001). Of 15 validated risk prediction models, the Adult Appendicitis Score performed best (cut‐off score 8 or less, specificity 63·1 per cent, failure rate 3·7 per cent). The Appendicitis Inflammatory Response Score performed best for men (cut‐off score 2 or less, specificity 24·7 per cent, failure rate 2·4 per cent).
Conclusion
Women in the UK had a disproportionate risk of admission without surgical intervention and had high rates of normal appendicectomy. Risk prediction models to support shared decision‐making by identifying adults in the UK at low risk of appendicitis were identified
First Measurement of the Hubble Constant from a Dark Standard Siren using the Dark Energy Survey Galaxies and the LIGO/Virgo Binary-Black-hole Merger GW170814
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- Vasuth M
- Vecchio A
- Vedovato G
- Veitch J
- Veitch PJ
- Venkateswara K
- Venugopalan G
- Verkindt D
- Vetrano F
- Vicere A
- Viets AD
- Vine DJ
- Vinet J-Y
- Vitale S
- Vivanco FH
- Vo T
- Vocca H
- Vorvick C
- Vyatchanin SP
- Wade AR
- Wade LE
- Wade M
- Walet R
- Walker AR
- Walker M
- Wallace L
- Walsh S
- Wang G
- Wang H
- Wang JZ
- Wang WH
- Wang YF
- Ward RL
- Warden ZA
- Warner J
- Was M
- Watchi J
- Weaver B
- Wechsler R
- Wei L-W
- Weinert M
- Weinstein AJ
- Weiss R
- Wellmann F
- Wen L
- Wessel EK
- Wessels P
- Wester W
- Westhouse JW
- Wette K
- Whelan JT
- Whiting BF
- Whittle C
- Wilken DM
- Williams D
- Williams PKG
- Williamson AR
- Willis JL
- Willke B
- Wimmer MH
- Winkler W
- Wipf CC
- Wittel H
- Woan G
- Woehler J
- Wofford JK
- Worden J
- Wright JL
- Wu DS
- Wysocki DM
- Xiao L
- Yamamoto H
- Yancey CC
- Yang L
- Yap MJ
- Yazback M
- Yeeles DW
- Yu H
- Yu H
- Yuen SHR
- Yvert M
- Zadrozny AK
- Zanolin M
- Zelenova T
- Zendri J-P
- Zertuche LM
- Zevin M
- Zhang J
- Zhang L
- Zhang T
- Zhao C
- Zhou M
- Zhou Z
- Zhu XJ
- Zimmerman A
- Zucker ME
- Zuntz J
- Zweizig J
- Publication venue
- IOP PUBLISHING LTD
- Publication date
- 01/05/2019
- Field of study
We present a multi-messenger measurement of the Hubble constant H 0 using the binary–black-hole merger GW170814 as a standard siren, combined with a photometric redshift catalog from the Dark Energy Survey (DES). The luminosity distance is obtained from the gravitational wave signal detected by the Laser Interferometer Gravitational-Wave Observatory (LIGO)/Virgo Collaboration (LVC) on 2017 August 14, and the redshift information is provided by the DES Year 3 data. Black hole mergers such as GW170814 are expected to lack bright electromagnetic emission to uniquely identify their host galaxies and build an object-by-object Hubble diagram. However, they are suitable for a statistical measurement, provided that a galaxy catalog of adequate depth and redshift completion is available. Here we present the first Hubble parameter measurement using a black hole merger. Our analysis results in H0=75−32+40kms−1Mpc−1, which is consistent with both SN Ia and cosmic microwave background measurements of the Hubble constant. The quoted 68% credible region comprises 60% of the uniform prior range [20, 140] km s−1 Mpc−1, and it depends on the assumed prior range. If we take a broader prior of [10, 220] km s−1 Mpc−1, we find {H}_{0 {78}_{-24}^{+96}\,\mathrm{km}\,{{\rm{s}}}^{-1}\,{\mathrm{Mpc}}^{-1} (57% of the prior range). Although a weak constraint on the Hubble constant from a single event is expected using the dark siren method, a multifold increase in the LVC event rate is anticipated in the coming years and combinations of many sirens will lead to improved constraints on H 0
Histoplasmosis in HIV-Infected Patients: A Review of New Developments and Remaining Gaps
- Author
- A Allard
- A Chakrabarti
- A LeMonte
- AC Bulmer
- AL Colombo
- B Pan
- C Munoz
- CA Benson
- CA Hage
- CA Hage
- CA Hage
- CA Kauffman
- CA Kauffman
- CA Kauffman
- CM Fernandez Andreu
- CM Scheel
- CM Scheel
- D Skillman
- DN Kroetz
- DS McKinsey
- DS McLeod
- F Huber
- G Breton
- HR Ashbee
- J Wheat
- J Wheat
- J Wheat
- JA Edwards
- JA Smith
- JL Cloud
- JL Cloud
- JW Baddley
- K Karimi
- L Ajello
- L Segura
- LB Pontes
- LJ Wheat
- LJ Wheat
- LJ Wheat
- LJ Wheat
- LJ Wheat
- LJ Wheat
- LJ Wheat
- LZ Goldani
- M Arango
- M Assi
- M Hanf
- M Hanf
- M Muniz Mde
- M Nacher
- M Nacher
- M Nacher
- M Nacher
- ME Gutierrez
- ME Gutierrez
- MO Xavier
- N Singh
- O Lortholary
- O Moquet
- P Couppie
- P Garsaud
- P Loulergue
- PA Connolly
- PC Johnson
- PG Jones
- PG Pappas
- R Cruz
- R Gopalakrishnan
- RA Hajjeh
- S Antinori
- S Ranque
- S Riviere
- S Simon
- ST Darling
- T Kasuga
- V Peigne
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Secular Trends in Body Height — Indicator of General Improvement In Living Conditions or of a Change in Specific Factors?
- Author
- A Wrzosek
- AF Roche
- Australian Bureau of Statistics
- B Bogin
- C Miguel de
- C Susanne
- D Frayer
- DF Roberts
- DF Roberts
- DM Styne
- DS Falconer
- DZ Loesch
- F Sobral
- G Weber
- GA Oyedeji
- GJ Louw
- GL Pretty
- HA Delemarrevandewaal
- J Piontek
- JA Gutierrez-Muniz
- JH Spurgeon
- JM Prince
- JV Wieringen van
- K Kimura
- K Mathers
- KA Dettwyler
- KH Jacobs
- KV Rao
- LA Proos
- LL Cavalli-Sforza
- M Henneberg
- M Henneberg
- M Henneberg
- M Henneberg
- M Henneberg
- M Henneberg
- M Henneberg
- M Henneberg
- M Henneberg
- M Prokopec
- N Moishezon-Blank
- N Soar
- N Wolanski
- OG Eiben
- P Brown
- PL Jamison
- PV Tobias
- PV Tobias
- PV Tobias
- RC Hauspie
- RC Hauspie
- RM Malina
- S Rosenbaum
- SJ Ulijaszek
- T Bielicki
- TL Leatherman
- WH Mueller
- WJM Gerver
- YC Huang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2001
- Field of study
Use of a Synthetic Biosensor for Neutralizing Activity-Biased Selection of Monoclonal Antibodies against Atroxlysin-I, an Hemorrhagic Metalloproteinase from Bothrops atrox Snake Venom
- Author
- A Kasturiratne
- AC Patiño
- ACO Cintra
- AM Moura-da-Silva
- B Lomonte
- B Lomonte
- BG Fry
- BG Fry
- C Baldo
- C Battellino
- Carlos Chávez-Olortegui
- Christophe Nguyen
- Claude Granier
- D Laune
- D Williams
- DA Warrell
- Dung Le Nguyen
- E Csuhai
- E Hansson
- E Hansson
- EF Sanchez
- EG Muniz
- Eladio Flores Sanchez
- Francisco Santos Schneider
- Franck Molina
- FS Markland Jr
- FS Schneider
- GD Laing
- GP Espino-Solis
- GP Queiroz
- H Gausepohl
- H Kondo
- I Fernandes
- I Tanjoni
- I Tanjoni
- J White
- JA Eble
- JJ Calvete
- JL Lopez-Lozano
- JM Gutierrez
- JM Gutierrez
- José María Gutiérrez
- JW Fox
- JW Fox
- Karen Larissa Castro
- KU Camey
- M Kohlhoff
- MI Estevao-Costa
- MM Kanashiro
- N Morine
- N Vidal
- NAC Tavares
- Nivia de Assis Ferreira
- OHP Ramos
- Pascale Galéa
- PK Akao
- R Otero
- R Otero-Patino
- RA Harrison
- Ricardo Andrez Machado de Avila
- RMS Terra
- Sandra Cobo
- SR Zamuner
- T Escalante
- TS Frauches
- V Moreira
- V Nunez
- V Nunez
- W Stocker
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- Field of study
Characterization of the wheat endosperm transfer cell-specific protein TaPR60
- Author
- A Andreeva
- A Bolhuis
- A Brands
- A Cenci
- A Funakoshi
- A Nicholls
- A Sali
- A Serna
- A Sokolenko
- Ainur Ismagul
- AL Mah
- AL Wu
- Andrew S. Milligan
- B John
- B Rost
- BJ Mayer
- C Barrero
- C Hueros
- DNP Doan
- E Gomez
- F Baud
- F Cruz-Garcia
- FK Bedford
- G Hueros
- GN Ramachandran
- HL Wang
- HM Berman
- I Callebaut
- I Diaz
- I Ezcurra
- J Dong
- J Sambrook
- JA Kreps
- JB Peltier
- JC Sanford
- JCM Rodrigues
- Jessica Smith
- JF Gutierrez-Marcos
- K Ginalski
- K Higo
- K Karplus
- L Chen
- L Gao
- LA Kelley
- LG Ryden
- LK Massey
- LM Muniz
- LT Hunt
- M Ellerstrom
- M Fedorova
- M Funakoshi
- M Funakoshi
- M Hiltunen
- M Li
- M Maitz
- Margaret Pallotta
- Maria Hrmova
- MD Curtis
- MF Kleijnen
- MJ Sippl
- MJ Sippl
- N Guex
- N Pasquato
- Natalia Bazanova
- Nataliya Kovalchuk
- NJ Provart
- OA Olsen
- OA Olsen
- Peter Langridge
- PR Matthews
- PW Becraft
- PW Becraft
- QX Shen
- R Sanchez
- RA Burton
- RA Laskowski
- RD Thompson
- Rohan Singh
- S Bajaj
- S Biggins
- S Drea
- S Kim
- S Lopato
- S Tingay
- S Wada
- Sergiy Lopato
- Serik Eliby
- SL Wu
- T Fujiwara
- T Murashige
- T Pummi
- WF Broekaert
- Y Zhang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2009
- Field of study
The TaPR60 gene from bread wheat encodes a small cysteine-rich protein with a hydrophobic signal peptide, predicted to direct the TaPR60 protein to a secretory pathway. It was demonstrated by heterologous expression of recombinant TaPR60 protein that the signal peptide is recognized and cleaved in yeast cells. The full-length gene including promoter sequence of a TaPR60 orthologue was cloned from a BAC library of Triticum durum. A transcriptional promoter-GUS fusion was stably transformed into wheat, barley and rice. The strongest GUS expression in wheat and barley was found in the endosperm transfer cells, while in rice the promoter was active inside the starchy endosperm during the early stages of grain filling. The TaPR60 gene was also used as bait in a yeast two-hybrid screen. Five proteins were identified in the screen, and for some of these prey proteins, the interaction was confirmed by co-immunoprecipitation. The signal peptide binding proteins, TaUbiL1 and TaUbiL2, are homologues of animal proteins, which belong to proteolytic complexes, and therefore may be responsible for TaPR60 processing or degradation of the signal peptide. Other proteins that interact with TaPR60 may have a function in TaPR60 secretion or regulation of this process. Examination of a three dimensional model of TaPR60 suggested that this protein could be involved in binding of lipidic molecules.Nataliya Kovalchuk, Jessica Smith, Margaret Pallotta, Rohan Singh, Ainur Ismagul, Serik Eliby, Natalia Bazanova, Andrew S. Milligan, Maria Hrmova and Peter Langridge, et al
Comparison of Phylogeny, Venom Composition and Neutralization by Antivenom in Diverse Species of Bothrops Complex
- Author
- A Alape-Girón
- A Alape-Girón
- A Barlow
- A Kasturiratne
- A Keller
- A Segura
- A Zelanis
- AI Nesvizhskii
- AK Tashima
- AM Fenwick
- AM Moura-da-Silva
- AM Moura-da-Silva
- AM Moura-da-Silva
- AM Moura-da-Silva
- Ana M. Moura-da-Silva
- BG Fry
- C Baldo
- C Correa-Netto
- Carolina A. Nicolau
- D Pla
- DA Cidade
- EG Muniz
- EN Baramova
- GP Queiroz
- Hipócrates M. Chalkidis
- HL Gibbs
- HL Gibbs
- HL Gibbs
- I Tanjoni
- I Tanjoni
- Ida S. Sano-Martins
- Isa Lima-dos-Santos
- J Durban
- J Fernández
- JA Gené
- JC Daltry
- JC Modesto
- JJ Calvete
- JJ Calvete
- JJ Calvete
- JJ Calvete
- JJ Calvete
- JJ Calvete
- JJ Calvete
- JJ Calvete
- JJ Calvete
- JJ Calvete
- JJ Calvete
- JL Cardoso
- JM Gutierrez
- JM Gutierrez
- JM Gutiérrez
- JM Gutiérrez
- JM Gutiérrez
- JM Gutiérrez
- JM Gutiérrez
- José Antonio Portes-Junior
- José Gutiérrez
- Juliana L. Bernardoni
- JW Fox
- JW Fox
- KC Cardoso
- KU Camey
- Leijiane F. Sousa
- M Kohlhoff
- M Neiva
- M Ohler
- MA McLane
- MC Menezes
- MeF Furtado
- MM Saldarriaga
- NR Casewell
- P Saravia
- PA Carrasco
- Pedro S. Peixoto
- PPO Pardal
- RA Guercio
- RH Valente
- Richard H. Valente
- Rosa Helena V. Mourão
- RS Rodrigues
- S Kashima
- SM Serrano
- SM Serrano
- SP Mackessy
- Sâmella S. Oliveira
- T Xu
- TA Castoe
- V Núñez
- VL Cunha Bastos
- WH McDonald
- Y Angulo
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- Field of study
An upper limit to the photon fraction in cosmic rays above 10(19) eV from the Pierre Auger Observatory
- Author
- Abraham J
- Aglietta M
- Aguirre C
- Agura AL
- Albarracin FG
- Allard D
- Allekotte I
- Allison P
- Alvarez C
- Alvarez-Muniz J
- Ambrosio M
- Anchordoqui L
- Anjos JC
- Aramo C
- Arisaka K
- Armengaud E
- Arneodo F
- Arqueros F
- Asch T
- Asorey H
- Atulugama BS
- Aublin J
- Ave M
- Avila G
- Bacelar J
- Backer T
- Badagnani D
- Barbosa AF
- Barbosa HMJ
- Barkhausen M
- Barnhill D
- Barroso SLC
- Bauleo P
- Beatty J
- Beau T
- Becker BR
- Becker KH
- Bellido JA
- BenZvi S
- Berat C
- Bergmann T
- Berisso MG
- Bernardini P
- Bertou X
- Biermann PL
- Billoir P
- Blanch-Bigas O
- Blanco F
- Blasi P
- Bleve C
- Blumer H
- Boghrat P
- Bohacova M
- Bonifazi C
- Bonino R
- Boratav M
- Brack J
- Brunet JM
- Buchholz P
- Busca NG
- Caballero-Mora KS
- Cai B
- Camin DV
- Capdevielle JN
- Caruso R
- Castellina A
- Cataldi G
- Cazon L
- Cester R
- Chauvin J
- Chiavassa A
- Chinellato JA
- Chou A
- Chye J
- Claes D
- Clark PDJ
- Clay RW
- Clay SB
- Connolly B
- Cordier A
- Cotti U
- Coutu S
- Covault CE
- Cronin J
- D'Olivo JC
- D'Urso D
- Dagoret-Campagne S
- Darriulat P
- Daumiller K
- Dawson BR
- de Almeida RM
- de Carvalho LA
- De Donato C
- De Grande NS
- de Jong SJ
- de Mello WJM
- De Mitri I
- de Oliveira MAL
- de Souza V
- del Peral L
- Deligny O
- Della Selva A
- Delle Fratte C
- Dembinski H
- Di Giulio C
- Diaz JC
- do Amaral MG
- Dobrigkeit C
- Dornic D
- Dorofeev A
- Dova MT
- DuVernois MA
- Engel R
- Epele L
- Erdmann M
- Escobar CO
- Etchegoyen A
- Ewers A
- Falcke H
- Fauth AC
- Fazio D
- Fazzini N
- Fernandez A
- Ferrer F
- Ferry S
- Fick B
- Filevich A
- Filipcic A
- Fleck I
- Fokitis E
- Fonte R
- Frias DR
- Fuhrmann D
- Fulgione W
- Galicia JFV
- Garcia B
- Garcia-Pinto D
- Garrard L
- Garrido X
- Geenen H
- Gelmini G
- Gemmeke H
- Geranios A
- Ghia PL
- Giller M
- Gitto J
- Glass H
- Gobbi F
- Gold MS
- Gongora JP
- Gonzalez D
- Gonzalez JG
- Gonzalez M
- Gora D
- Gorgi A
- Gouffon P
- Grassi V
- Grillo A
- Grunfeld C
- Grupen C
- Guarino F
- Guedes GP
- Gutierrez J
- Hague JD
- Hamilton JC
- Harakeh MN
- Harari D
- Harmsma S
- Hartmann S
- Harton JL
- Healy MD
- Hebbeker T
- Heck D
- Herrero RG
- Hojvat C
- Homola P
- Horandel J
- Horneffer A
- Horvat M
- Hrabovsky M
- Iarlori M
- Insolia A
- Kaducak M
- Kalashev O
- Kampert KH
- Keilhauer B
- Kemp E
- Klages HO
- Kleifges M
- Kleinfeller J
- Knapik R
- Knapp J
- Koang DH
- Kolotaev Y
- Kopmann A
- Kromer O
- Kuhlman S
- Kuijpers J
- Kunka N
- Kusenko A
- Lachaud C
- Lago BL
- Lebrun D
- LeBrun P
- Lee J
- Letessier-Selvon A
- Leuthold M
- Lhenry-Yvon I
- Longo G
- Lopez R
- Lucero A
- Maldera S
- Malek M
- Maltezos S
- Mancarella G
- Mancenido ME
- Mandat D
- Mantsch P
- Mariazzi AG
- Maris IC
- Martello D
- Martinez J
- Martinez N
- Martinez O
- Martino JR
- Mathes HJ
- Matthews J
- Matthews JAJ
- Matthiae G
- Maurin G
- Maurizio D
- Mazur PO
- McCauley T
- McEwen M
- McNeil RR
- Medina G
- Medina MC
- Meli A
- Melo D
- Menichetti E
- Menshikov A
- Meurer C
- Meyhandan R
- Micheletti MI
- Miele G
- Miller W
- Mollerach S
- Monasor M
- Montanet F
- Morales B
- Morello C
- Moreno E
- Morris C
- Mostafa M
- Muller MA
- Mussa R
- Navarra G
- Nellen L
- Neto JRTD
- Newman-Holmes C
- Newton D
- Ngoc DP
- Nichol R
- Nierstenhofer N
- Nitz D
- Nogima H
- Nosek D
- Nozka L
- Oehlschlager J
- Ohnuki T
- Olinto A
- Oliveira LFA
- Olmos-Gilbaja VM
- Ortiz M
- Ostapchenko S
- Otero L
- Palatka M
- Pallotta J
- Parente G
- Parizot E
- Parlati S
- Patel M
- Paul T
- Payet K
- Pech M
- Peixoto CJT
- Pekala J
- Pelayo R
- Pepe IM
- Perrone L
- Petrera S
- Petrinca P
- Petrov Y
- Piegaia R
- Pierog T
- Pisanti O
- Porter TA
- Pouryamout J
- Prado L
- Privitera P
- Prouza M
- Quang TD
- Quel EJ
- Ragaigne DM
- Rautenberg J
- Reis HC
- Reucroft S
- Revenu B
- Ridky J
- Risi A
- Risse M
- Riviere C
- Rizi V
- Robbins S
- Roberts M
- Robledo C
- Rodriguez G
- Rojo JR
- Ros G
- Rosado J
- Roth M
- Roucelle C
- Rouille-d'Orfeuil B
- Roulet E
- Roulet E
- Rovero AC
- Rovero AC
- Salamida F
- Salazar H
- Salina G
- San Luis PF
- Sanchez F
- Santander M
- Santos EM
- Sarkar S
- Sato R
- Scherini V
- Schmidt T
- Scholten O
- Schovanek P
- Schussler F
- Sciutto SJ
- Scuderi M
- Semikoz D
- Sequeiros G
- Shellard RC
- Siffert BB
- Sigl G
- Skelton P
- Slater W
- Smialkowski A
- Smida R
- Smith BE
- Snow GR
- Sokolsky P
- Sommers P
- Sorokin J
- Spinka H
- Strazzeri E
- Stutz A
- Suarez F
- Suomijarvi T
- Supanitsky AD
- Swain J
- Szadkowski Z
- Tamashiro A
- Tamburro A
- Tanco GM
- Tascau O
- Thi TN
- Thi TNP
- Ticona R
- Timmermans C
- Tkaczyk W
- Tonachini A
- Torresi D
- Travnicek P
- Tripathi A
- Tristram G
- Tscherniakhovski D
- Tueros M
- Tunnicliffe V
- Ulrich R
- Unger M
- Urban M
- Valino I
- Valore L
- van den Berg AM
- van Elewyck V
- Van TV
- Vazquez RA
- Veberic D
- Veiga A
- Velarde A
- Venters T
- Verzi V
- Videla M
- Villasenor L
- Vorobiov S
- Voyvodic L
- Wahlberg H
- Wainberg O
- Waldenmaier T
- Walker P
- Warner D
- Watson AA
- Westerhoff S
- Wiebusch C
- Wieczorek G
- Wiencke L
- Wilczynska B
- Wilczynski H
- Wileman C
- Winnick MG
- Xu J
- Yamamoto T
- Younk P
- Zas E
- Zavrtanik D
- Zavrtanik M
- Zech A
- Zepeda A
- Zha M
- Ziolkowski M
- Publication venue
- Publication date
- 01/01/2007
- Field of study