238 research outputs found
Study of the Anti-Proliferative Activity of 5-Substituted 4,7-Dimethoxy-1,3-Benzodioxole Derivatives of SY-1 from Antrodia camphorata on Human COLO 205 Colon Cancer Cells
A set of 10 4,7-dimethoxy-1,3-benzodioxole derivatives based on a lead compound previously discovered by our group, SY-1, which was isolated from Antrodia camphorata, were evaluated for their in vitro inhibitory activity on human colorectal carcinoma cells (COLO 205). Structure-activity relationship studies of the 10 compounds indicated the importance of the chain length of the alkyl group at the 5-position, and the 2-propenyl substituent named âapioleâ exhibited the most potent inhibitory activity. In the present study, we demonstrate that the SY-1 analogue âapioleâ decreased the proliferation of COLO 205 cells, but not that of normal human colonic epithelial cells (FHC). The G0/G1 cell cycle arrest induced by apiole (75â225âÎźM) was associated with significantly increased levels of p53, p21 and p27 and decreased levels of cyclin D1. Concerning COLO 205 cell apoptosis, apiole (>150âÎźM) treatment significantly increased the levels of cleaved caspases 3, 8, 9 and bax/bcl-2 ratio and induced ladder formation in DNA fragmentation assay and sub-G1 peak in flow cytometry analysis. These findings suggest that apiole can suppress COLO 205 cell growth; however, the detailed mechanisms of these processes require further investigation
The Origin of the White Roman Goose
In order to avoid interference from nuclear copies of mitochondrial DNA (numts), mtDNA of the white Roman goose (domestic goose) was extracted from liver mitochondria. The mtDNA control region was amplified using a long PCR strategy and then sequenced. Neighbor-joining, maximum parsimony, and maximum-likelihood approaches were implemented using the 1,177 bp mtDNA control region sequences to compute the phylogenetic relationships of the domestic goose with other geese. The resulting identity values for the white Roman geese were 99.1% (1,166/1,177) with western graylag geese and 98.8% (1,163/1,177) with eastern graylag geese. In molecular phylogenetic trees, the white Roman goose was grouped in the graylag lineage, indicating that the white Roman goose came from the graylag goose (Anser anser). Thus, the scientific name of the white Roman goose should be Anser anser 'White Roman.'
Power-law entropy-corrected HDE and NADE in Brans-Dicke cosmology
Considering the power-law corrections to the black hole entropy, which appear
in dealing with the entanglement of quantum fields inside and outside the
horizon, the holographic energy density is modified accordingly. In this paper
we study the power-law entropy-corrected holographic dark energy in the
framework of Brans-Dicke theory. We investigate the cosmological implications
of this model in detail. We also perform the study for the new agegraphic dark
energy model and calculate some relevant cosmological parameters and their
evolution. {As a result we find that this model can provide the present cosmic
acceleration and even the equation of state parameter of this model can cross
the phantom line provided the model parameters are chosen suitably}.Comment: 14 pages, 2 figure, accepted by IJT
H-Ras oncogene counteracts the growth-inhibitory effect of genistein in T24 bladder carcinoma cells
Among eight human bladder cancer cell lines we examined, only T24 cells were resistant to the growth inhibition effect of genistein, an isoflavone and potent anticancer drug. Since the T24 cell line was the only cell line known to overexpress oncogenic H-Ras(val12), we investigated the role of H-Ras(val 12) in mediating drug resistance. Herein, we demonstrate that the phenotype of T24 cells could be dramatically reversed and became relatively susceptible to growth inhibition by genistein if the synthesis of H- Ras(val 12) or its downstream effector c-Fos had been suppressed. The inhibition of Ras-mediated signalling with protein kinase inhibitors, such as PD58059 and U0126 which inhibited MEK and ERK, in T24 cells also rendered the identical phenotypic reversion. However, this reversion was not observed when an inhibitor was used to suppress the protein phosphorylation function of PI3 K or PKC. These results suggest that the signal mediated by H-Ras(val 12) is predominantly responsible for the resistance of the cells to the anticancer drug genistein
The in-plane paraconductivity in La_{2-x}Sr_xCuO_4 thin film superconductors at high reduced-temperatures: Independence of the normal-state pseudogap
The in-plane resistivity has been measured in (LSxCO)
superconducting thin films of underdoped (), optimally-doped
() and overdoped () compositions. These films were grown
on (100)SrTiO substrates, and have about 150 nm thickness. The in-plane
conductivity induced by superconducting fluctuations above the superconducting
transition (the so-called in-plane paraconductivity, ) was
extracted from these data in the reduced-temperature range
10^{-2}\lsim\epsilon\equiv\ln(T/\Tc)\lsim1. Such a
was then analyzed in terms of the
mean-field--like Gaussian-Ginzburg-Landau (GGL) approach extended to the
high- region by means of the introduction of a total-energy cutoff,
which takes into account both the kinetic energy and the quantum localization
energy of each fluctuating mode. Our results strongly suggest that at all
temperatures above Tc, including the high reduced-temperature region, the
doping mainly affects in LSxCO thin films the normal-state properties and that
its influence on the superconducting fluctuations is relatively moderate: Even
in the high- region, the in-plane paraconductivity is found to be
independent of the opening of a pseudogap in the normal state of the underdoped
films.Comment: 35 pages including 10 figures and 1 tabl
Convergence of energy-dependent incommensurate antiferromagnetic neutron scattering peaks to commensurate resonance in underdoped bilayer cuprates
The recently discovered coexistence of incommensurate antiferromagnetic
neutron scattering peaks and commensurate resonance in underdoped
YBaCuO is calling for an explanation. Within the t-J model, the
doping and energy dependence of the spin dynamics of the underdoped bilayer
cuprates in the normal state is studied based on the fermion-spin theory by
considering the bilayer interactions. Incommensurate peaks are found at
and at low energies with
initially increasing with doping at low dopings and then saturating at
higher dopings. These incommensurate peaks are suppressed, and the parameter
is reduced with increasing energy. Eventually it converges to the
resonance peak. Thus the recently observed coexistence is
interpreted in terms of bilayer interactions.Comment: 15 pages, Revtex, five figures are included, accepted for publication
in Phys. Rev.
Holographic Dark Energy in Brans-Dicke Theory
In this paper, the holographic dark energy model is considered in Brans-Dicke
theory where the holographic dark energy density is replaced with . Here
is a time variable Newton constant. With this
replacement, it is found that no accelerated expansion universe will be
achieved when the Hubble horizon is taken as the role of IR cut-off. When the
event horizon is adopted as the IR cut-off, an accelerated expansion universe
is obtained. In this case, the equation of state of holographic dark energy
takes a modified form
. In the limit , the 'standard' holographic dark energy is recovered. In the holographic
dark energy dominated epoch, power-law and de Sitter time-space solutions are
obtained.Comment: 7 pages, 1 figure, match the published versio
Search for a W' boson decaying to a bottom quark and a top quark in pp collisions at sqrt(s) = 7 TeV
Results are presented from a search for a W' boson using a dataset
corresponding to 5.0 inverse femtobarns of integrated luminosity collected
during 2011 by the CMS experiment at the LHC in pp collisions at sqrt(s)=7 TeV.
The W' boson is modeled as a heavy W boson, but different scenarios for the
couplings to fermions are considered, involving both left-handed and
right-handed chiral projections of the fermions, as well as an arbitrary
mixture of the two. The search is performed in the decay channel W' to t b,
leading to a final state signature with a single lepton (e, mu), missing
transverse energy, and jets, at least one of which is tagged as a b-jet. A W'
boson that couples to fermions with the same coupling constant as the W, but to
the right-handed rather than left-handed chiral projections, is excluded for
masses below 1.85 TeV at the 95% confidence level. For the first time using LHC
data, constraints on the W' gauge coupling for a set of left- and right-handed
coupling combinations have been placed. These results represent a significant
improvement over previously published limits.Comment: Submitted to Physics Letters B. Replaced with version publishe
Search for the standard model Higgs boson decaying into two photons in pp collisions at sqrt(s)=7 TeV
A search for a Higgs boson decaying into two photons is described. The
analysis is performed using a dataset recorded by the CMS experiment at the LHC
from pp collisions at a centre-of-mass energy of 7 TeV, which corresponds to an
integrated luminosity of 4.8 inverse femtobarns. Limits are set on the cross
section of the standard model Higgs boson decaying to two photons. The expected
exclusion limit at 95% confidence level is between 1.4 and 2.4 times the
standard model cross section in the mass range between 110 and 150 GeV. The
analysis of the data excludes, at 95% confidence level, the standard model
Higgs boson decaying into two photons in the mass range 128 to 132 GeV. The
largest excess of events above the expected standard model background is
observed for a Higgs boson mass hypothesis of 124 GeV with a local significance
of 3.1 sigma. The global significance of observing an excess with a local
significance greater than 3.1 sigma anywhere in the search range 110-150 GeV is
estimated to be 1.8 sigma. More data are required to ascertain the origin of
this excess.Comment: Submitted to Physics Letters
Measurement of the Lambda(b) cross section and the anti-Lambda(b) to Lambda(b) ratio with Lambda(b) to J/Psi Lambda decays in pp collisions at sqrt(s) = 7 TeV
The Lambda(b) differential production cross section and the cross section
ratio anti-Lambda(b)/Lambda(b) are measured as functions of transverse momentum
pt(Lambda(b)) and rapidity abs(y(Lambda(b))) in pp collisions at sqrt(s) = 7
TeV using data collected by the CMS experiment at the LHC. The measurements are
based on Lambda(b) decays reconstructed in the exclusive final state J/Psi
Lambda, with the subsequent decays J/Psi to an opposite-sign muon pair and
Lambda to proton pion, using a data sample corresponding to an integrated
luminosity of 1.9 inverse femtobarns. The product of the cross section times
the branching ratio for Lambda(b) to J/Psi Lambda versus pt(Lambda(b)) falls
faster than that of b mesons. The measured value of the cross section times the
branching ratio for pt(Lambda(b)) > 10 GeV and abs(y(Lambda(b))) < 2.0 is 1.06
+/- 0.06 +/- 0.12 nb, and the integrated cross section ratio for
anti-Lambda(b)/Lambda(b) is 1.02 +/- 0.07 +/- 0.09, where the uncertainties are
statistical and systematic, respectively.Comment: Submitted to Physics Letters
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