727 research outputs found

    Eliminating Disparities in Clinical Trials

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    Discovering predictive variables when evolving cognitive models

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    A non-dominated sorting genetic algorithm is used to evolve models of learning from different theories for multiple tasks. Correlation analysis is performed to identify parameters which affect performance on specific tasks; these are the predictive variables. Mutation is biased so that changes to parameter values tend to preserve values within the population's current range. Experimental results show that optimal models are evolved, and also that uncovering predictive variables is beneficial in improving the rate of convergence

    Multiobjective Algorithms Hybridization to Optimize Broadcasting Parameters in Mobile Ad-Hoc Networks

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    Proceeding of: 10th InternationalWork-Conference on Artificial Neural Networks, IWANN 2009 Salamanca, Spain, June 10-12, 2009The aim os this paper is to study the hybridization of two multi-objective algorithms in the context of a real problem, the MANETs problem. The algorithms studied are Particle Swarm Optimization (MOPSO) and a new multiobjective algorithm based in the combination of NSGA-II with Evolution Strategies (ESN). This work analyzes the improvement produced by hybridization over the Pareto’s fronts compared with the non-hybridized algorithms. The purpose of this work is to validate how hybridization of two evolutionary algorithms of different families may help to solve certain problems together in the context of MANETs problem. The hybridization used for this work consists on a sequential execution of the two algorithms and using the final population of the first algorithm as initial population of the second one.This article has been financed by the Spanish founded research MEC projects OPLINK::UC3M, Ref:TIN2005-08818- C04-02 and MSTAR::UC3M, Ref:TIN2008-06491-C04-03.Publicad

    Electromagnetic sources distributed on shells in a Schwarzschild background

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    In the Introduction we briefly recall our previous results on stationary electromagnetic fields on black-hole backgrounds and the use of spin-weighted spherical harmonics. We then discuss static electric and magnetic test fields in a Schwarzschild background using some of these results. As sources we do not consider point charges or current loops like in previous works, rather, we analyze spherical shells with smooth electric or magnetic charge distributions as well as electric or magnetic dipole distributions depending on both angular coordinates. Particular attention is paid to the discontinuities of the field, of the 4-potential, and their relation to the source.Comment: dedicated to Professor Goldberg's 86th birthday, accepted for publication in Gen. Relat. Gravit., 12 page

    High Order Multistep Methods with Improved Phase-Lag Characteristics for the Integration of the Schr\"odinger Equation

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    In this work we introduce a new family of twelve-step linear multistep methods for the integration of the Schr\"odinger equation. The new methods are constructed by adopting a new methodology which improves the phase lag characteristics by vanishing both the phase lag function and its first derivatives at a specific frequency. This results in decreasing the sensitivity of the integration method on the estimated frequency of the problem. The efficiency of the new family of methods is proved via error analysis and numerical applications.Comment: 36 pages, 6 figure

    Treadmill exercise activates subcortical neural networks and improves walking after a stroke

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    BACKGROUND AND PURPOSE: Stroke often impairs gait thereby reducing mobility and fitness and promoting chronic disability. Gait is a complex sensorimotor function controlled by integrated cortical, subcortical, and spinal networks. The mechanisms of gait recovery after stroke are not well understood. This study examines the hypothesis that progressive task-repetitive treadmill exercise (T-EX) improves fitness and gait function in subjects with chronic hemiparetic stroke by inducing adaptations in the brain (plasticity).METHODS: A randomized controlled trial determined the effects of 6-month T-EX (n=37) versus comparable duration stretching (CON, n=34) on walking, aerobic fitness and in a subset (n=15/17) on brain activation measured by functional MRI.RESULTS: T-EX significantly improved treadmill-walking velocity by 51% and cardiovascular fitness by 18% (11% and -3% for CON, respectively; P<0.05). T-EX but not CON affected brain activation during paretic, but not during nonparetic limb movement, showing 72% increased activation in posterior cerebellar lobe and 18% in midbrain (P<0.005). Exercise-mediated improvements in walking velocity correlated with increased activation in cerebellum and midbrain.CONCLUSIONS: T-EX improves walking, fitness and recruits cerebellum-midbrain circuits, likely reflecting neural network plasticity. This neural recruitment is associated with better walking. These findings demonstrate the effectiveness of T-EX rehabilitation in promoting gait recovery of stroke survivors with long-term mobility impairment and provide evidence of neuroplastic mechanisms that could lead to further refinements in these paradigms to improve functional outcomes

    Energy Distribution in f(R) Gravity

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    The well-known energy problem is discussed in f(R) theory of gravity. We use the generalized Landau-Lifshitz energy-momentum complex in the framework of metric f(R) gravity to evaluate the energy density of plane symmetric solutions for some general f(R) models. In particular, this quantity is found for some popular choices of f(R) models. The constant scalar curvature condition and the stability condition for these models are also discussed. Further, we investigate the energy distribution of cosmic string spacetime.Comment: 15 pages, accepted for publication in Gen. Relativ. & Gra

    Low-energy excitations in the three-dimensional random-field Ising model

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    The random-field Ising model (RFIM), one of the basic models for quenched disorder, can be studied numerically with the help of efficient ground-state algorithms. In this study, we extend these algorithm by various methods in order to analyze low-energy excitations for the three-dimensional RFIM with Gaussian distributed disorder that appear in the form of clusters of connected spins. We analyze several properties of these clusters. Our results support the validity of the droplet-model description for the RFIM.Comment: 10 pages, 9 figure

    Cold Dark Matter detection in SUSY models at large tan(beta)

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    We study the direct detection rate for SUSY cold dark matter (CDM) predicted by the minimal supersymmetric standard model with universal boundary conditions and large values for tan(beta). The relic abundance of the lightest supersymmetric particle (LSP), assumed to be approximately a bino, is obtained by including its coannihilations with the next-to-lightest supersymmetric particle (NLSP), which is the lightest s-tau. The cosmological constraint on this quantity severely limits the allowed SUSY parameter space, especially in the case the CP-even Higgs has mass of around 114 GeV. We find that for large tan(beta) it is possible to find a subsection of the allowed parameter space, which yields detectable rates in the currently planned experiments.Comment: Changes in text and figure

    ParadisEO-MOEO: A Software Framework for Evolutionary Multi-Objective Optimization

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    This chapter presents ParadisEO-MOEO, a white-box object-oriented software framework dedicated to the flexible design of metaheuristics for multi-objective optimization. This paradigm-free software proposes a unified view for major evolutionary multi-objective metaheuristics. It embeds some features and techniques for multi-objective resolution and aims to provide a set of classes allowing to ease and speed up the development of computationally efficient programs. It is based on a clear conceptual distinction between the solution methods and the problems they are intended to solve. This separation confers a maximum design and code reuse. This general-purpose framework provides a broad range of fitness assignment strategies, the most common diversity preservation mechanisms, some elitistrelated features as well as statistical tools. Furthermore, a number of state-of-the-art search methods, including NSGA-II, SPEA2 and IBEA, have been implemented in a user-friendly way, based on the fine-grained ParadisEO-MOEO components
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