49 research outputs found

    User guide for the Biosphere Isotope Domains GB (Version 1) dataset and web portal

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    This report is a user guide for the Biosphere Isotope Domains GB (V1) dataset, which includes (1) a GIS layer for strontium, sulphur and oxygen isotopes (2) datasets of strontium and sulphur isotope measurements from samples across the Great Britain - published separately and available via BGS and (3) a web portal for viewing and querying the data. A description of the data, methodology and assumptions used in the construction of the Biosphere Isotope Domains GB map is included in the associated publications for strontium (Evans, 2018) and sulphur (Chenery, 2018). The primary application of such datasets is for determining the provenance of skeletal material; although the data may also be of use in modern traceability studies of fauna and flora

    Lift, Drag and Thrust Measurement in a Hypersonic Impulse Facility

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    This paper reports the extension of the stress wave force balance to the measurement of forces on models which are non-axisymmetric or which have non-axisymmetric load distributions. Recent results are presented which demonstrate the performance of the stress wave force balance for drag measurement, for three-component force measurement and preliminary results for thrust measurement on a two-dimensional scramjet nozzle. In all cases, the balances respond within a few hundred microseconds

    Applying lead (Pb) isotopes to explore mobility in humans and animals

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    Lead (Pb) isotopes provide a complementary method to other provenance tools for tracking the origin and movement of humans and animals. The method is founded in the geographic distribution of Pb isotope ratios. However, unlike the Sr isotope method that is closely linked to the lithology of underlying rocks, Pb more closely reflects the tectonic regimes. This makes it particularly pertinent to use in Britain as there is major tectonic boundary (the Iapetus Suture) that runs between Berwick-upon-Tweed and the Solway Firth providing a compositional boundary in Pb isotope domains that approximates to the geographic areas of Scotland versus England and Wales. Modern pollution makes it difficult to use modern floral or faunal samples to characterize biosphere variation, and so we use geological datasets to define isoscape variation and present the first Pb isotope map of Britain. We have validated the use of these data form biosphere studies using well provenanced samples. Reference fields of diagnostic compositions, are created in Ό-T space and these have been used in a test case to assess the geographic origins of Neolithic animals in Great Britain

    Production of siderophore by coagulase-negative staphylococci and its relation to virulence

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    The ability to produce siderophore is considered to be a virulence factor for many pathogenic bacteria. To determine if siderophore production by coagulase-negative staphylococci (CNS) was related to virulence, 40 clinical isolates of CNS cultured from peritoneal dialysis fluid were compared with 38 commensal skin isolates. Siderophore activity was detected using the chrome azurol S liquid assay. Using precursor studies, Staphylococcus epidermidis isolates were shown to be more likely to produce the siderophore staphyloferrin A. Production of staphyloferrin B amongst non-Staphylococcus epidermidis species was associated with clinical isolates rather than commensal isolates, and therefore may play a role in pathogenicit

    Experimental Investigation of an Intake Injected Scramjet with a Wall Temperature of 800K

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    Isothermic and fixed-intensity heat acclimation methods elicit equal increases in Hsp72 mRNA

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    Thermotolerance, to which Heat shock protein-72 (Hsp72) contributes, is an acquired state achieved following heat acclimation (HA), eliciting cellular adaption and protection against thermal stress. Optimal HA methods achieving the greatest heat shock response (HSR) are equivocal; therefore investigation of methods provoking the greatest sustained HSR is required to optimise cellular adaptation. Twenty four males performed short term HA (STHA; five sessions) and long term HA (LTHA; STHA plus further five sessions) utilising fixed intensity (FIXED; workload = 50%V ̇O2peak), continuous isothermic HA (ISOCONT; target rectal temperature (TÂŹrec) = 38.5°C) or progressive isothermic HA (ISOPROG; target Trec = 38.5°C for STHA then target Trec = 39.0°C for LTHA). Leukocyte Hsp72 mRNA was measured pre and post day 1, day 5 and day 10 of HA via qRT-PCR to determine the HSR. Hsp72 mRNA increased (p 0.05). The equal Hsp72 mRNA increases occurring from consistent, reduced or increased endogenous strain following STHA and LTHA suggest that transcription occurs following attainment of sufficient endogenous criteria. These data give confidence that all reported HA methods increase Hsp72 mRNA and are capable of eliciting adaptations towards thermotolerance
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