Multibeam Maser Survey of methanol and excited OH in the Magellanic clouds: new detections and maser abundance estimates

‘The definitive version is available at www.blackwell-synergy.com.’ Copyright Blackwell Publishing DOI: 10.1111/j.1365-2966.2008.12888.xPeer reviewe

Ultrasonic Stimulation of Mouse Skin Reverses the Healing Delays in Diabetes and Aging by Activation of Rac1

Chronic skin-healing defects are one of the leading challenges to lifelong well-being, affecting 2–5% of populations. Chronic wound formation is linked to age and diabetes and frequently leads to major limb amputation. Here we identify a strategy to reverse fibroblast senescence and improve healing rates. In healthy skin, fibronectin activates Rac1 in fibroblasts, causing migration into the wound bed, and driving wound contraction. We discover that mechanical stimulation of the skin with ultrasound can overturn healing defects by activating a calcium/CamKinaseII/Tiam1/Rac1 pathway that substitutes for fibronectin-dependent signaling and promotes fibroblast migration. Treatment of diabetic and aged mice recruits fibroblasts to the wound bed and reduces healing times by 30%, restoring healing rates to those observed in young, healthy animals. Ultrasound treatment is equally effective in rescuing the healing defects of animals lacking fibronectin receptors, and can be blocked by pharmacological inhibition of the CamKinaseII pathway. Finally, we discover that the migration defects of fibroblasts from human venous leg ulcer patients can be reversed by ultrasound, demonstrating that the approach is applicable to human chronic samples. By demonstrating that this alternative Rac1 pathway can substitute for that normally operating in the skin, we identify future opportunities for management of chronic wounds

A twistor-like D=10 superparticle action with manifest N=8 world-line supersymmetry

We propose a new formulation of the $D=10$ Brink-Schwarz superparticle which is manifestly invariant under both the target-space super-Poincar\'e group and the world-line local $N=8$ superconformal group. This twistor-like construction naturally involves the sphere $S^8$ as a coset space of the $D=10$ Lorentz group. The action contains only a finite set of auxiliary fields, but they appear in unusual trilinear combinations. The origin of the on-shell $D=10$ fermionic $\kappa$ symmetry of the standard Brink-Schwarz formulation is explained. The coupling to a $D=10$ super-Maxwell background requires a new mechanism, in which the electric charge appears only on shell as an integration constant.Comment: 22pages, standard LATEX fil

Cardiolipin provides an essential activating platform for caspase-8 on mitochondria

Cardiolipin is a mitochondria-specific phospholipid known to be intimately involved with apoptosis. However, the lack of appropriate cellular models to date restricted analysis of its role in cell death. The maturation of cardiolipin requires the transacylase tafazzin, which is mutated in the human disorder Barth syndrome. Using Barth syndrome patient-derived cells and HeLa cells in which tafazzin was knocked down, we show that cardiolipin is required for apoptosis in the type II mitochondria-dependent response to Fas stimulation. Cardiolipin provides an anchor and activating platform for caspase-8 translocation to, and embedding in, the mitochondrial membrane, where it oligomerizes and is further activated, steps that are necessary for an efficient type II apoptotic response

Erosion-flooding interaction on a UK barrier

This paper presents a multi-temporal (centennial, decadal, event-based) analysis of Blakeney Spit, a mixed sand-gravel barrier located on the UK’s east coast. Since 2006, Blakeney Spit has experienced a less interventionist management approach that contrasts with the earlier regime of periodically bulldozing parts of the barrier to maintain a steeper cross-shore profile. Given recent endorsements of coastal management schemes that work with, rather than against, nature this case study provides a valuable opportunity to quantify the impact of management regime change on shoreline erosion rates, overwash processes and associated flood hazard

Flooding-erosion interactions: implications for coastal risk management

As routinely experienced coastal hazards, flooding and erosion are key considerations within coastal management plans and policy. Flooding and erosion hazards are often analysed separately, without due attention to their interaction. Low lying barrier islands exemplify coastal environments particularly affected by erosion-flooding interactions. Such environments often support substantial human populations, critical infrastructure, and diverse ecosystems. This study undertakes a high resolution, multidecadal shoreline change analysis at Blakeney Point, a mixed sand-gravel spit on the UK’s North Norfolk coast. The analysis spans two distinct management regimes: the ‘first era’ (1992-2005) where the eastern section of the barrier was periodically artificially reprofiled into a steep-sided trapezoid with a narrow crest; and the ‘second era’ (2006-2016) of no active intervention along the entire barrier. We find that over the past 130 years, Blakeney Point has retreated landward at a mean rate of 0.60 m a-1. Along the eastern section of Blakeney Point, we observe an increase in shoreline retreat rate between the two eras of 3 to 30 times depending on the choice of shoreline proxy (High Water Line, ridge line, or vegetation line). The lower shoreline retreat rates during the first era suggest that reprofiling fixed the shoreline position of the eastern barrier. Termination of the reprofiling regime, in combination with storm surge events in 2007 and 2013, resulted in accelerated retreat along the eastern section towards a more landward position. This has had implications for the western section of the spit which appears to have benefited from alongshore westward transport of sediment during the noninterventionist era, resulting in slowed landward retreat rates during this period. The importance of storm surge events should not be understated. During 2013-2014, overwashing along the eastern section of the barrier resulted in vegetation line retreat of up to 127 m. This retreat behaviour was not matched at lower elevations on the subaerial beach, suggesting lateral spreading of the barrier, a behaviour which has been shown elsewhere to involve increased landward retreat and barrier disintegration. Our findings suggest a change in the morphological character of the barrier under the non-interventionist management regime, with clear implications for erosion, flooding and their interactio

Identification of functionally distinct macrophage subpopulations in Drosophila

Vertebrate macrophages are a highly heterogeneous cell population, but while Drosophila blood is dominated by a macrophage-like lineage (plasmatocytes), until very recently these cells were considered to represent a homogeneous population. Here, we present our identification of enhancer elements labelling plasmatocyte subpopulations, which vary in abundance across development. These subpopulations exhibit functional differences compared to the overall population, including more potent injury responses and differential localisation and dynamics in pupae and adults. Our enhancer analysis identified candidate genes regulating plasmatocyte behaviour: pan-plasmatocyte expression of one such gene (Calnexin14D) improves wound responses, causing the overall population to resemble more closely the subpopulation marked by the Calnexin14D-associated enhancer. Finally, we show that exposure to increased levels of apoptotic cell death modulates subpopulation cell numbers. Taken together this demonstrates macrophage heterogeneity in Drosophila, identifies mechanisms involved in subpopulation specification and function and facilitates the use of Drosophila to study macrophage heterogeneity in vivo

Lepton Flavor Violating Process in Bi-maximal texture of Neutrino Mixings

We investigate the lepton flavor violation in the framework of the MSSM with right-handed neutrinos taking the large mixing angle MSW solution in the quasi-degenerate and the inverse-hierarchical neutrino masses. We predict the branching ratio of $\mu \to e+\gamma$ and $\tau \to \mu+\gamma$ processes assuming the degenerate right-handed Majorana neutrino masses. We find that the branching ratio in the quasi-degenerate neutrino mass spectrum is 100 times smaller than the ones in the inverse-hierarchical and the hierarchical neutrino spectra. We emphasize that the magnitude of $U_{e3}$ is one of important ingredients to predict BR($\mu \to e +\gamma$). The effect of the deviation from the complete-degenerate right-handed Majorana neutrino masses are also estimated. Furtheremore, we examine the S_{3\sL}\times S_{3\sR} model, which gives the quasi-degenerate neutrino masses, and the Shafi-Tavartkiladze model, which gives the inverse-hierarchical neutrino masses. Both predicted branching ratios of $\mu\to e+\gamma$ are smaller than the experimantal bound.Comment: Latex file, 38 pages, 10 figures, revised versio

The effect of asymmetries on stock index return value-at-risk estimates

It is widely accepted that equity return volatility increases more following negative shocks rather than positive shocks. However, much of value-at-risk (VaR) analysis relies on the assumption that returns are normally distributed (a symmetric distribution). This article considers the effect of asymmetries on the evaluation and accuracy of VaR by comparing estimates based on various models