Quasispecies evolution in general mean-field landscapes

I consider a class of fitness landscapes, in which the fitness is a function of a finite number of phenotypic "traits", which are themselves linear functions of the genotype. I show that the stationary trait distribution in such a landscape can be explicitly evaluated in a suitably defined "thermodynamic limit", which is a combination of infinite-genome and strong selection limits. These considerations can be applied in particular to identify relevant features of the evolution of promoter binding sites, in spite of the shortness of the corresponding sequences.Comment: 6 pages, 2 figures, Europhysics Letters style (included) Finite-size scaling analysis sketched. To appear in Europhysics Letter

Effect of Dilution on Microstructure and Wear Resistance of a Fe-Based Hardfacing Alloy with a High Amount of Carbide-Forming Elements

Hardfacing is a widely diffused technique adopted to increase service life of parts for heavy-duty applications. Even though hardfacing alloys feature optimized chemistry and microstructure for specific service conditions, dilution with substrate modifies the resulting properties along a significant fraction of the deposit thickness. In particular, C and B diffusion to the substrate alters hypereutectic alloys reducing the carbide-forming ability andmodifying the solidification sequence. In the present paper, the effect of dilution on a hypereutectic Fe-C-B based alloy containing Cr and Mo was investigated. The effect of dilution on the reference alloy was studied by producing laboratory castings with an increased amount of Fe, up to 50 mass %. The obtained results were compared with the dilution of the hardfacing alloy cast on steel substrates. The microstructural evolution was analyzed by XRD (X-ray diffraction), differential scanning calorimetry (DSC), optical microscopy (OM), and scanning electron microscopy (SEM), whereas mechanical behaviour was evaluated by hardness measurements and wear resistance by pin-on-disc tests

Extending the Role of Analogies in the Teaching of Physics

Research in physics teaching has supported the use of analogies as an effective instructional tool that can be used to facilitate students’ understanding of physics concepts. The effectiveness of analogies lies in that they allow students to form cognitive links between what they already know and what they are learning, harmoniously integrating, in this way, the new physics concepts into their existing knowledge. In this paper, it is suggested that analogies could be extended to provide physics teachers with a diagnostic form of assessment that can reveal both the misconceptions their students may hold, the prior knowledge upon which such misconceptions are based, as well as knowledge sources that can be productively used in the teaching process. This suggestion arises from the findings of a cross-age study in which students, from five different age groups, were asked to make predictions about a range of situations they had not previously encountered (novel situations) and explain the reasons that led them to make those predictions

Vanishing Fe 3d orbital moments in single-crystalline magnetite

We show detailed magnetic absorption spectroscopy results of an in situ cleaved high quality single crystal of magnetite. In addition the experimental setup was carefully optimized to reduce drift, self absorption, and offset phenomena as far as possible. In strong contradiction to recently published data, our observed orbital moments are nearly vanishing and the spin moments are quite close to the integer values proposed by theory. This very important issue supports the half metallic full spin polarized picture of magnetite.Comment: 7 pages, 4 figure

The Voices of History: theorising the interpersonal semantics of historical discourses

‘The individual consumer, the learner of history, is offered an impressive array of discursive products geared to catch his or her attention, to persuade him or her of the truth of whatever message is transmitted’ (Blanco and Rosa 1997: 197. In this article I examine these discursive products from the perspective of ‘voice’. I do this as a way of bringing to conscious attention the strategies that historians use in order to persuade and position the ‘consumer’. ‘Voice’ in recent systemic linguistic theorizing refers to distinctive configurations of APPRAISAL choices. Within the domain of history, research to date has identified three main configurations or voices—‘recorder’, ‘interpreter’, and ‘adjudicator’. Central to the research reported on in this article is Martin’s APPRAISAL framework (Martin 1997, 2000). APPRAISAL 1 systems are the semantic resources used to negotiate emotions, judgments, and valuations. In this article I will examine how choices from these systems vary in ways that are systematic — different history texts speak with different ‘voices’. These voices, I argue, are a key rhetorical strategy in history discourse. Different combinations of APPRAISAL resources are drawn on to negotiate the heteroglossic positions of their audiences. As such they are a key resource for both the professional and apprentice historian in their assessment of interpretations of the past

Onto better TRAILs for cancer treatment

Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL), also known as Apo-2 ligand (Apo2L), is a member of the TNF cytokine superfamily. By cross-linking TRAIL-Receptor (TRAIL-R) 1 or TRAIL-R2, also known as death receptors 4 and 5 (DR4 and DR5), TRAIL has the capability to induce apoptosis in a wide variety of tumor cells while sparing vital normal cells. The discovery of this unique property among TNF superfamily members laid the foundation for testing the clinical potential of TRAIL-R-targeting therapies in the cancer clinic. To date, two of these therapeutic strategies have been tested clinically: (i) recombinant human TRAIL and (ii) antibodies directed against TRAIL-R1 or TRAIL-R2. Unfortunately, however, these TRAIL-R agonists have basically failed as most human tumors are resistant to apoptosis induction by them. It recently emerged that this is largely due to the poor agonistic activity of these agents. Consequently, novel TRAIL-R-targeting agents with increased bioactivity are currently being developed with the aim of rendering TRAIL-based therapies more active. This review summarizes these second-generation novel formulations of TRAIL and other TRAIL-R agonists, which exhibit enhanced cytotoxic capacity toward cancer cells, thereby providing the potential of being more effective when applied clinically than first-generation TRAIL-R agonists

Optical Lattice Induced Light Shifts in an Yb Atomic Clock

We present an experimental study of the lattice induced light shifts on the 1S_0-3P_0 optical clock transition (v_clock~518 THz) in neutral ytterbium. The ``magic'' frequency, v_magic, for the 174Yb isotope was determined to be 394 799 475(35)MHz, which leads to a first order light shift uncertainty of 0.38 Hz on the 518 THz clock transition. Also investigated were the hyperpolarizability shifts due to the nearby 6s6p 3P_0 - 6s8p 3P_0, 6s8p 3P_2, and 6s5f 3F_2 two-photon resonances at 759.708 nm, 754.23 nm, and 764.95 nm respectively. By tuning the lattice frequency over the two-photon resonances and measuring the corresponding clock transition shifts, the hyperpolarizability shift was estimated to be 170(33) mHz for a linear polarized, 50 uK deep, lattice at the magic wavelength. In addition, we have confirmed that a circularly polarized lattice eliminates the J=0 - J=0 two-photon resonance. These results indicate that the differential polarizability and hyperpolarizability frequency shift uncertainties in a Yb lattice clock could be held to well below 10^-17.Comment: Accepted to PR

Dynamic optimal taxation with human capital.

This paper revisits the dynamic optimal taxation results of Jones, Manuelli, and Rossi (1993, 1997). They use a growth model with human capital and find that optimal taxes on both capital income and labor income converge to zero in steady state. For one of the models under consideration, I show that the representative household's problem does not have an interior solution. This raises concerns since these corners are inconsistent with aggregate data. Interiority is restored if preferences are modified so that human capital augments the value of leisure time. With this change, the optimal tax problem is analyzed and, reassuringly, the Jones, Manuelli, and Rossi results are confirmed: neither capital income nor labor income should be taxed in steady state

The Embedded Super Star Cluster of SBS0335-052

We analyze the infrared (6-100 micron) spectral energy distribution of the blue compact dwarf and metal-poor (Z=Z_solar/41) galaxy SBS0335-052. With the help of DUSTY (Ivezic et al. 1999), a program that solves the radiation transfer equations in a spherical environment, we evaluate that the infrared (IR) emission of SBS0335-052 is produced by an embedded super-star cluster (SSC) hidden under 10^5 M_solar of dust, causing 30 mag of visual extinction. This implies that one cannot detect any stellar emission from the 2x10^6 M_solar stellar cluster even at near-infrared (NIR) wavelengths. The derived grain size distribution departs markedly from the widely accepted size distribution inferred for dust in our galaxy (the so-called MRN distribution, Mathis et al. 1977), but resembles what is seen around AGNs, namely an absence of PAH and smaller grains, and grains that grow to larger sizes (around 1 micron). The fact that a significant amount of dust is present in such a low-metallicity galaxy, hiding from UV and optical view most of the star formation activity in the galaxy, and that the dust size distribution cannot be reproduced by a standard galactic law, should be borne in mind when interpreting the spectrum of primeval galaxies.Comment: 32 pages, 3 figures,accepted for publication in A