The Curious Case of Metonymic Verbs: A Distributional Characterization

Logical metonymy combines an event-selecting verb with an entity-denoting noun (e.g.,The writer began the novel), triggering a covert event interpretation (e.g., reading, writing). Experimental investigations of logical metonymy must assume a binary distinction between metonymic (i.e. event-selecting) verbs and non-metonymic verbs to establish a control condition. However, this binary distinction (whether a verb is metonymic or not) is mostly made on intuitive grounds, which introduces a potential confounding factor. We describe a corpus-based approach which characterizes verbs in terms of their behavior at the syntax-semantics interface. The model assesses the extent to which transitive verbs prefer event-denoting objects over entity-denoting objects. We then test this “eventhood” measure on psycholinguistic datasets, showing that it can distinguish not only metonymic from non-metonymic verbs, but that it can also capture more fine-grained distinctions among different classes of metonymic verbs, putting such distinctions into a new graded perspective

Fitting, Not Clashing! A Distributional Semantic Model of Logical Metonymy

Logical metonymy interpretation (e.g. begin the book ->writing) has received wide attention in linguistics. Experimental results have shown higher processing costs for metonymic conditions compared with non-metonymic ones ( read the book). According to a widely held interpretation, it is the type clash between the event-selecting verb and the entity-denoting object (begin the book) that triggers coercion mechanisms and leads to additional processing effort. We propose an alternative explanation and argue that the extra processing effort is an effect of thematic fit. This is a more economical hypothesis that does not need to postulate a separate type clash mechanism: entity-denoting objects simply have a low fit as objects of event-selecting verbs. We test linguistic datasets from psycholinguistic experiments and find that a structured distributional model of thematic fit, which does not encode any explicit argument type information, is able to replicate all significant experimental findings. This result provides evidence for a graded account of coercion phenomena in which thematic fit accounts for both the trigger of the coercion and the retrieval of the covert even

Contingent electric shock as a treatment for challenging behavior for people with intellectual and developmental disabilities : support for the IASSIDD policy statement opposing its use

Issues: The International Association for the Scientific Study of Intellectual and Developmental Disabilities (IASSIDD) is an international group of researchers, clinicians, students, parents, and self-advocates that promotes worldwide research and exchange of information on intellectual and developmental disabilities. IASSIDD recently developed a policy statement regarding their opposition to the use of contingent electric skin shock (CESS) with individuals with challenging behaviour and intellectual and developmental disabilities. To support the policy, the available literature was reviewed to evaluate the efficacy, side effects, generalization, and long-term effectiveness of the procedure as an intervention for challenging behaviour. Findings: The review provides a history that demonstrates that, although CESS can decrease the frequency of challenging behaviour, it comes at a cost in terms of physical and emotional side effects, and questions remain regarding the long-term effectiveness of the procedure. In addition, we raise several ethical and methodological issues that make the research on the use of CESS even more concerning. Conclusions: Although research continues in some countries, these studies are now rare. In fact, in the United States, the Food and Drug Administration has just banned the use of such devices with individuals with self-injury and aggression (Federal Register, 2020). It is hoped that, because there are many other forms of treatment that have shown to be effective for severe challenging behaviour, we can completely avoid the use of CESS

Implementing quantum gates through scattering between a static and a flying qubit

We investigate whether a two-qubit quantum gate can be implemented in a scattering process involving a flying and a static qubit. To this end, we focus on a paradigmatic setup made out of a mobile particle and a quantum impurity, whose respective spin degrees of freedom couple to each other during a one-dimensional scattering process. Once a condition for the occurrence of quantum gates is derived in terms of spin-dependent transmission coefficients, we show that this can be actually fulfilled through the insertion of an additional narrow potential barrier. An interesting observation is that under resonance conditions the above enables a gate only for isotropic Heisenberg (exchange) interactions and fails for an XY interaction. We show the existence of parameter regimes for which gates able to establish a maximum amount of entanglement can be implemented. The gates are found to be robust to variations of the optimal parameters.Comment: 7 pages, 3 figure

Entanglement Controlled Single-Electron Transmittivity

We consider a system consisting of single electrons moving along a 1D wire in the presence of two magnetic impurities. Such system shows strong analogies with a Fabry - Perot interferometer in which the impurities play the role of two mirrors with a quantum degree of freedom: the spin. We have analysed the electron transmittivity of the wire in the presence of entanglement between the impurity spins. The main result of our analysis is that, for suitable values of the electron momentum, there are two maximally entangled state of the impurity spins the first of which makes the wire transparent whatever the electron spin state while the other strongly inhibits the electron transmittivity. Such predicted striking effect is experimentally observable with present day technology.Comment: Published version (6 figures

Two-dimensional hydrodynamic lattice-gas simulations of binary immiscible and ternary amphiphilic fluid flow through porous media

The behaviour of two dimensional binary and ternary amphiphilic fluids under flow conditions is investigated using a hydrodynamic lattice gas model. After the validation of the model in simple cases (Poiseuille flow, Darcy's law for single component fluids), attention is focussed on the properties of binary immiscible fluids in porous media. An extension of Darcy's law which explicitly admits a viscous coupling between the fluids is verified, and evidence of capillary effects are described. The influence of a third component, namely surfactant, is studied in the same context. Invasion simulations have also been performed. The effect of the applied force on the invasion process is reported. As the forcing level increases, the invasion process becomes faster and the residual oil saturation decreases. The introduction of surfactant in the invading phase during imbibition produces new phenomena, including emulsification and micellisation. At very low fluid forcing levels, this leads to the production of a low-resistance gel, which then slows down the progress of the invading fluid. At long times (beyond the water percolation threshold), the concentration of remaining oil within the porous medium is lowered by the action of surfactant, thus enhancing oil recovery. On the other hand, the introduction of surfactant in the invading phase during drainage simulations slows down the invasion process -- the invading fluid takes a more tortuous path to invade the porous medium -- and reduces the oil recovery (the residual oil saturation increases).Comment: 48 pages, 26 figures. Phys. Rev. E (in press

Reducing quantum control for spin-spin entanglement distribution

We present a protocol that sets maximum stationary entanglement between remote spins through scattering of mobile mediators without initialization, post-selection or feedback of the mediators' state. No time-resolved tuning is needed and, counterintuitively, the protocol generates two-qubit singlet states even when classical mediators are used. The mechanism responsible for such effect is resilient against non-optimal coupling strengths and dephasing affecting the spins. The scheme uses itinerant particles and scattering centres and can be implemented in various settings. When quantum dots and photons are used a striking result is found: injection of classical mediators, rather than quantum ones, improves the scheme efficiency.Comment: 7 pages, 5 figures, replaced with published versio

Functional characterisation of bone marrow-derived mesenchymal stromal cells from COPD patients

ABSTRACT Autologous bone marrow-derived mesenchymal stromal cells (BM-MSCs) are evaluated forclinical use in chronic obstructive pulmonary disease (COPD) patients, but it is unclear whether COPDaffects BM-MSCs.To investigate this, BM-MSCs from nine COPD patients and nine non-COPD age-matched controls werecompared with regard to immunophenotype, growth and differentiation potential, and migration capacity.Other functional assays included the response to pro-inflammatory stimuli and inducers of the nuclearfactor (erythroid derived 2)-like 2 antioxidant response element (Nrf2-ARE) pathway, and effects on NCIH292airway epithelial cells.No significant differences were observed in terms of morphology, proliferation and migration, except forincreased adipocyte differentiation potential in the COPD group. Both groups were comparable regardingmRNA expression of growth factors and inflammatory mediators, and in their potential to induce mRNAexpression of epidermal growth factor receptor ligands in NCI-H292 airway epithelial cells. MSCs fromCOPD patients secreted more interleukin-6 in response to pro-inflammatory stimuli. Activation of the Nrf2-ARE pathway resulted in a comparable induction of mRNA expression of four target genes, but theexpression of the NAD(P)H:quinone oxidoreductase 1 gene NQO1 was lower in MSCs from COPD patients.The observation that MSCs from COPD patients are phenotypically and functionally comparable tothose from non-COPD controls implies that autologous MSCs can be considered for use in the setting ofclinical trials as a treatment for COPD.Pathogenesis and treatment of chronic pulmonary disease

Momentum versus extinction effects in the treatment of self-injurious escape behavior.

An individual's self-injurious escape behavior was treated using a high-probability instructional sequence with and without extinction. When presented alone, the high-probability sequence did not reduce self-injurious behavior. When escape extinction was implemented either alone or in combination with the high-probability sequence, self-injury decreased and compliance increased, suggesting that extinction may be a necessary component of the treatment for behavior problems maintained by escape

Importance of Reward and Prefrontal Circuitry in Hunger and Satiety: Prader-Willi Syndrome vs. Simple Obesity

Background: The majority of research on obesity has focused primarily on clinical features (eating behavior, adiposity measures), or peripheral appetite-regulatory peptides (leptin, ghrelin). However, recent functional neuroimaging studies have demonstrated that some reward circuitry regions which are associated with appetite-regulatory hormones are also involved in the development and maintenance of obesity. Prader-Willi syndrome (PWS), characterized by hyperphagia and hyperghrelinemia reflecting multi-system dysfunction in inhibitory and satiety mechanisms, serves as an extreme model of genetic obesity. Simple (non-PWS) obesity (OB) represents an obesity control state. Objective: This study investigated subcortical food motivation circuitry and prefrontal inhibitory circuitry functioning in response to food stimuli before and after eating in individuals with PWS compared with OB. We hypothesized that groups would differ in limbic regions (i.e., hypothalamus, amygdala) and prefrontal regions associated with cognitive control [i.e., dorsolateral prefrontal cortex (DLPFC), orbitofrontal cortex (OFC)] after eating. Design and Participants: Fourteen individuals with PWS, 14 BMI- and age-matched individuals with OB, and 15 age-matched healthy-weight controls (HWC) viewed food and non-food images while undergoing functional MRI before (pre-meal) and after (post-meal) eating. Using SPM8, group contrasts were tested for hypothesized regions: hypothalamus, nucleus accumbens (NAc), amygdala, hippocampus, OFC, medial PFC, and DLPFC. Results: Compared with OB and HWC, PWS demonstrated higher activity in reward/limbic regions (NAc, amygdala) and lower activity in hypothalamus and hippocampus, in response to food (vs. non-food) images pre-meal. Post-meal, PWS exhibited higher subcortical activation (hypothalamus, amygdala, hippocampus) compared to OB and HWC. OB showed significantly higher activity versus PWS and HWC in cortical regions (DLPFC, OFC) associated with inhibitory control. Conclusion: In PWS compared with obesity per se, results suggest hyperactivations in subcortical reward circuitry and hypoactivations in cortical inhibitory regions after eating, which provides evidence of neural substrates associated with variable abnormal food motivation phenotypes in PWS and simple obesity