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Electromagnetic wave refraction at an interface of a double wire medium

Plane-wave reflection and refraction at an interface with a double wire medium is considered. The problem of additional boundary conditions (ABC) in application to wire media is discussed and an ABC-free approach, known in the solid state physics, is used. Expressions for the fields and Poynting vectors of the refracted waves are derived. Directions and values of the power density flow of the refracted waves are found and the conservation of the power flow through the interface is checked. The difference between the results, given by the conventional model of wire media and the model, properly taking into account spatial dispersion, is discussed.Comment: 17 pages, 11 figure

Polycythemia is uncommon in dogs with chronic hypoxic pulmonary disease

Background Prolonged tissue hypoxia caused by chronic pulmonary disease is commonly regarded as an important mechanism in the development of secondary polycythemia, but little clinical data are available to support this hypothesis. Objective To study the prevalence and severity of erythrocytosis accompanying chronic hypoxic pulmonary disease in dogs. Animals Forty-seven dogs with hypoxic chronic pulmonary disease, 27 dogs with nonhypoxic chronic pulmonary disease, and 60 healthy controls. Methods Dogs with chronic pulmonary disease and chronic hypoxemia (partial pressure of arterial oxygen [PaO2] = 65%) was noted in any of the dogs. Red blood cell parameters were not associated with the severity of hypoxemia (correlation to PaO2: Erytr, r = -.14; Hb, r = -.21; Hct, r = -.14; P > .05 for all). Conclusions and Clinical Importance Polycythemia is uncommon, and usually mild if present, in dogs with chronic hypoxia caused by pulmonary disease.Peer reviewe

The link among X-ray spectral properties, AGN structure and the host galaxy

In this work, we compare the SMBH and host galaxy properties of X-ray obscured and unobscured AGN. For that purpose, we use $\sim 35 000$ X-ray detected AGN in the 4XMM-DR11 catalogue for which there are available measurements for their X-ray spectral parameters, from the XMM2Athena Horizon 2020 European project. We calculate the host galaxy properties via SED fitting analysis. Our final sample consists of 1 443 AGN. In the first part of our analysis, we use different N$_H$ thresholds (10$^{23}$ cm$^{-2}$ or 10$^{22}$ cm$^{-2}$), taking also into account the uncertainties associated with the N$_H$ measurements, to classify these sources into obscured and unobscured. We find that obscured AGN tend to live in more massive systems that have lower SFR compared to their unobscured counterparts. However, only the difference in stellar mass, M$_*$, appears statistically significant ($>2\sigma$). The results do not depend on the N$_H$ threshold used to classify AGN. The differences in M$_*$ and SFR are not statistically significant for luminous AGN ($\rm log (L_{X,2-10 KeV}/erg s^{-1})> 44$). Our findings also show that unobscured AGN have, on average, higher specific black hole accretion rates compared to their obscured counterparts. In the second part of our analysis, we cross-match the 1 443 X-ray AGN with the SDSS DR16 quasar catalogue to obtain information on the SMBH properties of our sources. This results in 271 type 1 AGN, at $\rm z<1.9$. Our findings show that type 1 AGN with increased N$_H$ ($>10^{22}$ cm$^{-2}$) tend to have higher M$_{BH}$ compared to AGN with lower N$_H$ values, at similar M$_*$. The M$_{BH}$/M$_*$ ratio remains consistent for N$_H$ values below 10$^{22}$ cm$^{-2}$, but it exhibits signs of an increase at higher N$_H$ values. Finally, we detect a correlation between $\Gamma$ and Eddington ratio, but only for type 1 sources with N$_H<10^{22}$ cm$^{-2}$.Comment: A&A accepted for publication. 15 pages, 15 figures, 3 tables. Abstract has been abridge

Primary familial brain calcification linked to deletion of 5' noncoding region of SLC20A2

OBJECTIVES: Primary familial brain calcification (PFBC) is a rare neurological disease often inherited as a dominant trait. Mutations in four genes (SLC20A2, PDGFB, PDGFRB, and XPR1) have been reported in patients with PFBC. Of these, point mutations or small deletions in SLC20A2 are most common. Thus far, only one large deletion covering entire SLC20A2 and several smaller, exonic deletions of SLC20A2 have been reported. The aim of this study was to identify the causative gene defect in a Finnish PFBC family with three affected patients. MATERIALS AND METHODS: A Finnish family with three PFBC patients and five unaffected subjects was studied. Sanger sequencing was used to exclude mutations in the coding and splice site regions of SLC20A2, PDGFRB, and PDGFB. Whole-exome (WES) and whole-genome sequencing (WGS) were performed to identify the causative mutation. A SNP array was used in segregation analysis. RESULTS: Copy number analysis of the WGS data revealed a heterozygous deletion of ~578 kb on chromosome 8. The deletion removes the 5' UTR region, the noncoding exon 1 and the putative promoter region of SLC20A2 as well as the coding regions of six other genes. CONCLUSIONS: Our results support haploinsufficiency of SLC20A2 as a pathogenetic mechanism in PFBC. Analysis of copy number variations (CNVs) is emerging as a crucial step in the molecular genetic diagnostics of PFBC, and it should not be limited to coding regions, as causative variants may reside in the noncoding parts of known disease-associated genes

Co-infections with Respiratory Viruses in Dogs with Bacterial Pneumonia

BackgroundBacterial pneumonia (BP) is an inflammation of the lower airways and lung parenchyma secondary to bacterial infection. The pathogenesis of BP in dogs is complex and the role of canine respiratory viruses has not been fully evaluated. ObjectivesThe aim of this study was to investigate the occurrence of viral co-infections in dogs with BP and to assess demographic or clinical variables as well as disease severity associated with viral co-infections. AnimalsTwenty household dogs with BP caused by opportunistic bacteria and 13 dogs with chronic (>30days) tracheobronchitis caused by Bordetella bronchiseptica (BBTB). MethodsProspective cross-sectional observational study. Diagnosis was confirmed by clinical and laboratory findings, diagnostic imaging, and cytologic and microbiologic analysis of bronchoalveolar lavage or transtracheal wash fluid. Canine parainfluenza virus (CPIV), canine adenovirus, canine herpes virus, canine influenzavirus, canine distemper virus, canine respiratory coronavirus (CRCoV) and canine pneumovirus, as well as B.bronchiseptica and Mycoplasma spp. were analyzed in respiratory samples using PCR assays. ResultsCPIV was detected in 7/20 and CRCoV in 1/20 dogs with BP. Respiratory viruses were not detected in dogs with BBTB. There were no significant differences in clinical variables between BP dogs with and without a viral co-infection. Conclusion and Clinical ImportanceRespiratory viruses were found frequently in dogs with BP and may therefore play an important role in the etiology and pathogenesis of BP. Clinical variables and disease severity did not differ between BP dogs with and without viral co-infection.Peer reviewe

Euclid: Fast two-point correlation function covariance through linear construction

We present a method for fast evaluation of the covariance matrix for a two-point galaxy correlation function (2PCF) measured with the Landy-Szalay estimator. The standard way of evaluating the covariance matrix consists in running the estimator on a large number of mock catalogs, and evaluating their sample covariance. With large random catalog sizes (random-to-data objects' ratio M >> 1) the computational cost of the standard method is dominated by that of counting the data-random and random-random pairs, while the uncertainty of the estimate is dominated by that of data-data pairs. We present a method called Linear Construction (LC), where the covariance is estimated for small random catalogs with a size of M = 1 and M = 2, and the covariance for arbitrary M is constructed as a linear combination of the two. We show that the LC covariance estimate is unbiased. We validated the method with PINOCCHIO simulations in the range r = 20-200 h(-1) Mpc. With M = 50 and with 2h(-1) Mpc bins, the theoretical speedup of the method is a factor of 14. We discuss the impact on the precision matrix and parameter estimation, and present a formula for the covariance of covariance.Peer reviewe