Overlapping regional security institutions in South America: The case of OAS and UNASUR

The Union of South American Nations (UNASUR) has positioned itself as a regional security organization aimed at reducing the influence of the Organization of American States (OAS) in South America. At the same time, the OAS paradoxically serves as a model for UNASUR because of its operational capacity and its legitimacy as a regional organization. This article analyzes the seemingly contradictory tendencies of replication and dissociation that UNASUR exhibits towards the OAS in terms of security conceptions and practices. In the first part of the paper, we will draw on recent debates on international regime complexity to develop a framework to study institutional overlap. The second part analyzes to what extent and in which respects UNASUR, and particularly its Defense Council, overlaps with the OAS in terms of security conceptions and practices, while the third part examines the causes of the emergence of a “competitor” for the OAS in South America

Quantitative Analysis of BTF3, HINT1, NDRG1 and ODC1 Protein Over-Expression in Human Prostate Cancer Tissue

Prostate carcinoma is the most common cancer in men with few, quantifiable, biomarkers. Prostate cancer biomarker discovery has been hampered due to subjective analysis of protein expression in tissue sections. An unbiased, quantitative immunohistochemical approach provided here, for the diagnosis and stratification of prostate cancer could overcome this problem. Antibodies against four proteins BTF3, HINT1, NDRG1 and ODC1 were used in a prostate tissue array (> 500 individual tissue cores from 82 patients, 41 case pairs matched with one patient in each pair had biochemical recurrence). Protein expression, quantified in an unbiased manner using an automated analysis protocol in ImageJ software, was increased in malignant vs non-malignant prostate (by 2-2.5 fold, p<0.0001). Operating characteristics indicate sensitivity in the range of 0.68 to 0.74; combination of markers in a logistic regression model demonstrates further improvement in diagnostic power. Triple-labeled immunofluorescence (BTF3, HINT1 and NDRG1) in tissue array showed a significant (p<0.02) change in co-localization coefficients for BTF3 and NDRG1 co-expression in biochemical relapse vs non-relapse cancer epithelium. BTF3, HINT1, NDRG1 and ODC1 could be developed as epithelial specific biomarkers for tissue based diagnosis and stratification of prostate cancer