Radial rift and block tectonics around the Tharsis bulge: Introductional postulation

Although the Vallis Marineris canyon and radial fossae grabens have been extensively studied, their origin and formation mechanism is still the subject of numerous questions. Possible rift formation is only one point of view and does not explain the rifting mechanism and the radial pattern of these structures around the Tharsis bulge. Both active and passive rifting must be taken into account. According to the active mechanism the building of a colcanic complex like the Tharsis bulge is caused by the rising of a huge mantle plume and adjoining extrusions which tap the generated magma. The surrounding fossae and valley structures are caused by more passive crustal rifting due to tensional failure of the surface layers. The main rising mantle plume activated and regenerated failure patterns radial to the centre of activity. These radial zones of weakness are then most easily utilized by the rising mantle plume. Deep zones of weakness regulate the penetration and distribution of hot mantle rock into upper levels while, contrarily, the effective impingement of the hot mantle plume into the lithosphere opens up new weakness zones

Cytherean crustal bending at Salme Dorsa

The Salme ridge belt can be interpreted as being the leading edge of a venusian crustal unit that moved against the highland foreland unit. It is indicative of a compressional zone, with a thrust front facing west. The Salme ridge belt with adjoining structures is an evident indication of lateral stresses and adjoining crustal movements on Venus. It supports the idea of southeast compression against and over the foreland planitia, which has bent under the load and/or lateral stress, resulting in trough and bulge formation in front of the ridge belt. The origin of the driving force for the movements remains masked. Laima Tessera is located in the direction from which the thrust is thought to apply but there are no appropriate candidates for a rift zone although a thrust from the southeast would be in good agreement with structures of Laima Tessera. The temperature gradient suggests that the lithosphere is approximately 12 km thick, while its elastic layer is approximately 3 km thick based either on the load-induced flexure model or on the compressional buckling model

IL1RN genetic variations and risk of IPF: a meta-analysis and mRNA expression study

Idiopathic pulmonary fibrosis (IPF) is a rare and devastating lung disease of unknown aetiology. Genetic variations in the IL1RN gene, encoding the interleukin-1 receptor antagonist (IL-1Ra), have been associated with IPF susceptibility. Several studies investigated the variable number tandem repeat (VNTR) or single nucleotide polymorphisms rs408392, rs419598 and rs2637988, with variable results. The aim of this study was to elucidate the influence of polymorphisms in IL1RN on IPF susceptibility and mRNA expression. We performed a meta-analysis of the five case–control studies that investigated an IL1RN polymorphism in IPF in a Caucasian population. In addition, we investigated whether IL1RN mRNA expression was influenced by IL1RN polymorphisms. The VNTR, rs408392 and rs419598 were in tight linkage disequilibrium, with D′ > 0.99. Furthermore, rs2637988 was in linkage disequilibrium with the VNTR (D′ = 0.90). A haploblock of VNTR*2 and the minor alleles of rs408392and rs419598 was constructed. Meta-analysis revealed that this VNTR*2 haploblock is associated with IPF susceptibility both with an allelic model (odds ratio = 1.42, p = 0.002) and a carriership model (odds ratio = 1.60, p = 0.002). IL1RN mRNA expression was significantly influenced by rs2637988, with lower levels found in carriers of the (minor) GG genotype (p < 0.001). From this meta-analysis, we conclude that the VNTR*2 haploblock is associated with susceptibility to IPF. In addition, polymorphisms in IL1RN influence IL-1Ra mRNA expression, suggesting that lower levels of IL-1Ra predispose to developing IPF. Together these findings demonstrate that the cytokine IL-1Ra plays a role in IPF pathogenesis

The mannose receptor negatively modulates the Toll-like receptor 4–aryl hydrocarbon receptor–indoleamine 2,3-dioxygenase axis in dendritic cells affecting T helper cell polarization

Background: Dendritic cells (DCs) are key players in the induction and re-elicitation of TH2 responses to allergens. We have previously shown that different C-type lectin receptors on DCs play a major role in allergen recognition and uptake. In particular, mannose receptor (MR), through modulation of Toll-like receptor (TLR) 4 signaling, can regulate indoleamine 2,3-dioxygenase (IDO) activity, favoring TH2 responses. Interestingly, the aryl hydrocarbon receptor (AhR), a ligand-dependent transcription factor with an emerging role in immune modulation, has been implicated in IDO activation in response to TLR stimulation. Objective: Here we investigated how allergens and lectins modulate the TLR4-AhR-IDO axis in human monocyte-derived DCs. Methods: Using a combination of genomics, proteomics, and immunologic studies, we investigated the role of MR and AhR in IDO regulation and its effect on T helper cell differentiation. Results: We have demonstrated that LPS induces both IDO isoforms (IDO1 and IDO2) in DCs, with partial involvement of AhR. Additionally, we found that, like mannan, different airborne allergens can effectively downregulate TLR4-induced IDO1 and IDO2 expression, most likely through binding to the MR. Mannose-based ligands were also able to downregulate IL-12p70 production by DCs, affecting T helper cell polarization. Interestingly, AhR and some components of the noncanonical nuclear factor κB pathway were shown to be downregulated after MR engagement, which could explain the regulatory effects of MR on IDO expression. Conclusion: Our work demonstrates a key role for MR in the modulation of the TLR4-AhR-IDO axis, which has a significant effect on DC behavior and the development of immune responses against allergens

Bulk components in lunar rocks

The deviations of principal lunar rock oxides collected from periodicals are presented in the form of frequency distribution graphs. The geochemical characteristics of rock types from different landing sites are briefly discussed. Of the major lunar rock components Al2O3, FeO, CaO and MnO are most indicative of terra-mare contrary. Terra rock classification is not unambiguous but mare basalts can be divided into high- and low-titanium basalts with several subgroups. Since lunar missions are few in number and are directed at restricted areas there are evidently still many unsampled lunar rock types

Micrometeorites from the northern ice cap of the Novaya Zemlya archipelago, Russia: The first occurrence

Glacial deposits at the margins of the ice cap of the northern island of the Novaya Zemlya archipelago, Russia, contain numerous spherules and rare scoriaceous particles thought to be extraterrestrial. The 1 Kyr old glacier has decreased in volume and coverage during the last 40 years, leaving the spherules contained in the ice at the margins of the glacier where they can be easily collected. The spherules are similar in their appearance, texture, and mineralogy to cosmic spherules found in deep-sea sediments in Greenland and Antarctica. Silicate spherules have typical bar-like textures (75%) or porphyritic textures (15%), while other spherules are glassy (7%). The spherules from Novaya Zemlya are altered only slightly. There are spherules consisting of iron oxides, metal cores with iron oxide rims, a continuous network of iron oxide dendrites in a glass matrix, and particles rich in chromite (3%). Some spherules contain metal droplets and relict forsterite and low-Ca pyroxene. Silicate spherule compositions match compositions of other cosmic spherules. Both Nova Zemlya and other cosmic spherules are close to carbonaceous chondrite matrices in patterns of variations for Ca, Mg, Si, and Al, which might suggest that their predecessor was similar to carbonaceous chondrite matrices. Unmelted micrometeorites are generally depleted in Ca and Mg and enriched in Al relative to cosmic spherules. The depletion of the micrometeorites in Ca and Mg can be connected with their terrestrial alteration (Kurat et al. 1994), while the Al enrichment seems to be primary.The Meteoritics & Planetary Science archives are made available by the Meteoritical Society and the University of Arizona Libraries. Contact [email protected] for further information.Migrated from OJS platform February 202