1,008 research outputs found
Augmented serum levels of the IGF-I/IGF-binding protein-3 ratio in pre-menopausal patients with type I breast cysts
Objective: Gross cystic disease (GCD) is the most common benign breast pathology. Although breast cysts are not considered pre-malignant lesions, an increased risk of breast cancer has been reported for patients with type I cysts (Na+/K+ < 3). Furthermore, an augmented IGF-I/IGF-binding protein-3 (IGFBP-3) ratio has been described in breast cancer patients. The objective was to evaluate serum IGF-I and binding protein concentrations of type I and type II cyst patients as compared with healthy women.
Methods: Twenty-four patients with type I cysts, 17 with type II cysts and 25 healthy women were evaluated. Serum IGF-I, IGFBP-3 and IGFBP-1 concentrations were measured by IRMA.
Results: IGF-I concentrations were significantly higher in sera from patients with type I cysts than in patients with type II cysts. A highly significant decrease of IGFBP-3, the major IGFBP, was found in patients with type I cysts with respect to healthy women, whereas no significant difference was evident between the different cyst types. The IGF-I/IGFBP-3 ratio, an estimate of biologically active IGF-I, was very significantly higher in patients with type I cysts than in both type II patients and healthy women. IGFBP-1 levels were significantly lower in patients with type I than in controls and type II cysts. The IGF-I/IGFBP-1 ratio was significantly higher in patients with type I cysts than in type II bearers and healthy women. Estrogen levels correlated with IGF-I in patients and controls.
Conclusions: The enhanced levels of IGF-I/IGFBP-3 found in patients with type I cysts could eventually be associated with the increased risk of breast cancer described for this group.Facultad de Ciencias Exacta
Augmented serum levels of the IGF-I/IGF-binding protein-3 ratio in pre-menopausal patients with type I breast cysts
Objective: Gross cystic disease (GCD) is the most common benign breast pathology. Although breast cysts are not considered pre-malignant lesions, an increased risk of breast cancer has been reported for patients with type I cysts (Na+/K+ < 3). Furthermore, an augmented IGF-I/IGF-binding protein-3 (IGFBP-3) ratio has been described in breast cancer patients. The objective was to evaluate serum IGF-I and binding protein concentrations of type I and type II cyst patients as compared with healthy women.
Methods: Twenty-four patients with type I cysts, 17 with type II cysts and 25 healthy women were evaluated. Serum IGF-I, IGFBP-3 and IGFBP-1 concentrations were measured by IRMA.
Results: IGF-I concentrations were significantly higher in sera from patients with type I cysts than in patients with type II cysts. A highly significant decrease of IGFBP-3, the major IGFBP, was found in patients with type I cysts with respect to healthy women, whereas no significant difference was evident between the different cyst types. The IGF-I/IGFBP-3 ratio, an estimate of biologically active IGF-I, was very significantly higher in patients with type I cysts than in both type II patients and healthy women. IGFBP-1 levels were significantly lower in patients with type I than in controls and type II cysts. The IGF-I/IGFBP-1 ratio was significantly higher in patients with type I cysts than in type II bearers and healthy women. Estrogen levels correlated with IGF-I in patients and controls.
Conclusions: The enhanced levels of IGF-I/IGFBP-3 found in patients with type I cysts could eventually be associated with the increased risk of breast cancer described for this group.Facultad de Ciencias Exacta
Meson model for f_0(980) production in peripheral pion-nucleon reactions
The Juelich model for pion-pion-scattering, based on an effective meson-meson
Lagrangian is applied to the analysis of the S-wave production amplitudes
derived from the BNL E852 experiment pi^- p -> pi^0 pi^0 n for a pion momentum
of 18.3 GeV. The unexpected strong dependence of the S-wave partial wave
amplitude on the momentum transfer between the proton and neutron in the
vicinity of the f_0(980) resonance is explained in our analysis as interference
effect between the correlated and uncorrelated pi^0 pi^0 pairs.Comment: 6 pages, 7 figures, formulas added, typos removed, new figure
Formation of the internal structure of solids under severe action
On the example of a particular problem, the theory of vacancies, a new form
of kinetic equations symmetrically incorporation the internal and free energies
has been derived. The dynamical nature of irreversible phenomena at formation
and motion of defects (dislocations) has been analyzed by a computer
experiment. The obtained particular results are extended into a thermodynamic
identity involving the law of conservation of energy at interaction with an
environment (the 1st law of thermodynamics) and the law of energy
transformation into internal degree of freedom (relaxation). The identity is
compared with the analogous Jarzynski identity. The approach is illustrated by
simulation of processes during severe plastic deformation, the Rybin kinetic
equation for this case has been derived.Comment: 9 pages, 5 figure
A General Solution to the Aircraft Trim Problem
Trim defines conditions for both design and analysis based on aircraft models. In fact, we often define these analysis points more broadly than the conditions normally associated with trim conditions to facilitate that analysis or design. In simulations, these analysis points establish initial conditions comparable to flight conditions. Based on aerodynamic and propulsion systems models of an aircraft, trim analysis can be used to provide the data needed to define the operating envelope or the performance characteristics. Linear models are typically derived at trim points. Control systems are designed and evaluated at points defined by trim conditions. And these trim conditions provide us a starting point for comparing one model against another, one implementation of a model against another implementation of the same model, and the model to flight-derived data. In this paper we define what we mean by trim, examine a variety of trim conditions that have proved useful and derive the equations defining those trim conditions. Finally we present a general approach to trim through constrained minimization of a cost function based on the nonlinear, six-degree-of freedom state equations coupled with the aerodynamic and propulsion system models. We provide an example of how a trim algorithm is used with a simulation by showing an example from JSBSim
Study of the reaction pbar p -> phi phi from 1.1 to 2.0 GeV/c
A study has been performed of the reaction pbar p -> 4K using in-flight
antiprotons from 1.1 to 2.0 GeV/c incident momentum interacting with a hydrogen
jet target. The reaction is dominated by the production of a pair of phi
mesons. The pbar p -> phi phi cross section rises sharply above threshold and
then falls continuously as a function of increasing antiproton momentum. The
overall magnitude of the cross section exceeds expectations from a simple
application of the OZI rule by two orders of magnitude. In a fine scan around
the xi/f_J(2230) resonance, no structure is observed. A limit is set for the
double branching ratio B(xi -> pbar p) * B(xi -> phi phi) < 6e-5 for a spin 2
resonance of M = 2.235 GeV and Width = 15 MeV.Comment: 13 pages, 13 figures, 2 tables, Latex. To be published in Phys. Rev.
Meson-meson scattering within one loop Chiral Perturbation Theory and its unitarization
We present the complete one-loop calculation of all the two meson scattering
amplitudes within the framework of SU(3) Chiral Perturbation Theory, which
includes pions, kaons and the eta. In addition, we have unitarized these
amplitudes with the coupled channel Inverse Amplitude Method, which ensures
simultaneously the good low energy properties of Chiral Perturbation Theory and
unitarity. We show how this method provides a remarkable description of
meson-meson scattering data up to 1.2 GeV including the scattering lengths and
the generation of seven light resonances, which is consistent with previous
determination of the chiral parameters. Particular attention is paid to discuss
the differences and similarities of this work with previous analysis in the
literature.Comment: 20 pages, 5 figures. Comments on sigma, kappa and eta', as well as
some references added. Final version to appear in Phys.Rev.
Optimal Flying Wings: A Numerical Optimization Study
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/97067/1/AIAA2012-1758.pd
Stability and Control Derivative Estimation for the Bell-Shaped Lift Distribution
No abstract availabl
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