On a Complete Set of Orthogonal F-Squares of Order 8 with a Mateless Latin Square

9 pages, 1 article*On a Complete Set of Orthogonal F-Squares of Order 8 with a Mateless Latin Square* (Federer, W. T.; Mandeli, J. P.; Schwager, S. J.) 9 page

On Embedding Mateless Latin Squares of Orders 12 and 16 in a Complete Set of Orthogonal F-Squares

17 pages, 1 article*On Embedding Mateless Latin Squares of Orders 12 and 16 in a Complete Set of Orthogonal F-Squares* (Federer, W. T.; Mandeli, J. P.; Schwager, S. J.) 17 page

Embedding Cyclic Latin Squares of Order 2 (n) in a Complete Set of Orthogonal F-Squares

This issue was undated. The date given is an estimate.18 pages, 1 article*Embedding Cyclic Latin Squares of Order 2 (n) in a Complete Set of Orthogonal F-Squares* (Schwager, S. J.; Federer, W. T.; Mandeli, J. P.) 18 page

F-Square Geometries for n = 3, 4, 5, and 6

19 pages, 1 article*F-Square Geometries for n = 3, 4, 5, and 6* (Federer, W. T.; Lee, F. C.; Mandeli, J. P.) 19 page

Pairwise Orthogonal F-Rectangle Designs

This issue was undated. The date given is an estimate.14 pages, 1 article*Pairwise Orthogonal F-Rectangle Designs* (Federer, W. T.; Hedayat, A. S.; Mandeli, J. P.) 14 page

A Manual of Transformations (and Graphs) Useful in Statistics

10 pages, 1 article*A Manual of Transformations (and Graphs) Useful in Statistics* (Mandeli, J. P.; Hall, D. B.) 10 page

A pituitary gene encodes a protein that produces differentiation of breast and prostate cancer cells

A cDNA clone of 1.1 kb encoding a 108-aa polypeptide was isolated from a human pituitary cDNA library by expression cloning. This protein was named tumor differentiation factor (TDF). The recombinant TDF protein and a 20-aa peptide, P1, selected from the ORF of the gene, induced morphological and biochemical changes consistent with differentiation of human breast and prostate cancer cells. Fibroblast, kidney, hepatoma, and leukemic lymphocytic cell lines were unaffected. Breast and prostate cancer cells aggregated in spheroid-like structures within 24 h of exposure to TDF. This effect was abrogated by a specific affinity-purified rabbit polyclonal anti-P1 Ab. E-cadherin expression was increased in a dose-dependent manner by TDF. Treatment of MCF7 cells with TDF led to production of a lactalbumin-related protein. Peptide P1 significantly decreased the growth of androgen-independent DU145 prostate cancer in severe combined immunodeficient mice. The presence of TDF protein in human sera was detected by the anti-P1 Ab, suggesting a role of TDF in endocrine metabolism. The fact that all activities of TDF can be mimicked by a peptide derived from the encoding TDF sequence opens the possibility of therapeutic applications