703 research outputs found
Tunneling Spectroscopy of Quasiparticle Bound States in a Spinful Josephson Junction
The spectrum of a segment of InAs nanowire, confined between two
superconducting leads, was measured as function of gate voltage and
superconducting phase difference using a third normal-metal tunnel probe.
Sub-gap resonances for odd electron occupancy---interpreted as bound states
involving a confined electron and a quasiparticle from the superconducting
leads, reminiscent of Yu-Shiba-Rusinov states---evolve into Kondo-related
resonances at higher magnetic fields. An additional zero bias peak of unknown
origin is observed to coexist with the quasiparticle bound states.Comment: Supplementary information available here:
https://dl.dropbox.com/u/1742676/Chang_Sup.pd
Dorsal-CA1 hippocampal neuronal ensembles encode nicotine-reward contextual associations
Natural and drug rewards increase the motivational valence of stimuli in the environment that, through Pavlovian learning mechanisms, become conditioned stimuli that directly motivate behavior in the absence of the original unconditioned stimulus. While the hippocampus has received extensive attention for its role in learning and memory processes, less is known regarding its role in drug-reward associations. We used in vivo Ca2+ imaging in freely moving mice during the formation of nicotine preference behavior to examine the role of the dorsal-CA1 region of the hippocampus in encoding contextual reward-seeking behavior. We show the development of specific neuronal ensembles whose activity encodes nicotine-reward contextual memories and that are necessary for the expression of place preference. Our findings increase our understanding of CA1 hippocampal function in general and as it relates to reward processing by identifying a critical role for CA1 neuronal ensembles in nicotine place preference
Stress-induced reinstatement of nicotine preference requires dynorphin/kappa opioid activity in the basolateral amygdala
UNLABELLED: The dynorphin (DYN)/kappa-opioid receptor (KOR) system plays a conserved role in stress-induced reinstatement of drug seeking for prototypical substances of abuse. Due to nicotine\u27s high propensity for stress-induced relapse, we hypothesized that stress would induce reinstatement of nicotine seeking-like behavior in a KOR-dependent manner. Using a conditioned place preference (CPP) reinstatement procedure in mice, we show that both foot-shock stress and the pharmacological stressor yohimbine (2 mg/kg, i.p.) induce reinstatement of nicotine CPP in a norbinaltorphimine (norBNI, a KOR antagonist)-sensitive manner, indicating that KOR activity is necessary for stress-induced nicotine CPP reinstatement. After reinstatement testing, we visualized robust c-fos expression in the basolateral amygdala (BLA), which was reduced in mice pretreated with norBNI. We then used several distinct but complementary approaches of locally disrupting BLA KOR activity to assess the role of KORs and KOR-coupled intracellular signaling cascades on reinstatement of nicotine CPP. norBNI injected locally into the BLA prevented yohimbine-induced nicotine CPP reinstatement without affecting CPP acquisition. Similarly, selective deletion of BLA KORs in KOR conditional knock-out mice prevented foot-shock-induced CPP reinstatement. Together, these findings strongly implicate BLA KORs in stress-induced nicotine seeking-like behavior. In addition, we found that chemogenetic activation of Gαi signaling within CaMKIIα BLA neurons was sufficient to induce nicotine CPP reinstatement, identifying an anatomically specific intracellular mechanism by which stress leads to reinstatement. Considered together, our findings suggest that activation of the DYN/KOR system and Gαi signaling within the BLA is both necessary and sufficient to produce reinstatement of nicotine preference.
SIGNIFICANCE STATEMENT: Considering the major impact of nicotine use on human health, understanding the mechanisms by which stress triggers reinstatement of drug-seeking behaviors is particularly pertinent to nicotine. The dynorphin (DYN)/kappa-opioid receptor (KOR) system has been implicated in stress-induced reinstatement of drug seeking for other commonly abused drugs. However, the specific role, brain region, and mechanisms that this system plays in reinstatement of nicotine seeking has not been characterized. Here, we report region-specific engagement of the DYN/KOR system and subsequent activation of inhibitory (Gi-linked) intracellular signaling pathways within the basolateral amygdala during stress-induced reinstatement of nicotine preference. We show that the DYN/KOR system is necessary to produce this behavioral state. This work may provide novel insight for the development of therapeutic approaches to prevent stress-related nicotine relapse
p-GaAs nanowire MESFETs with near-thermal limit gating
Difficulties in obtaining high-performance p-type transistors and gate
insulator charge-trapping effects present two major challenges for III-V
complementary metal-oxide semiconductor (CMOS) electronics. We report a p-GaAs
nanowire metal-semiconductor field-effect transistor (MESFET) that eliminates
the need for a gate insulator by exploiting the Schottky barrier at the
metal-GaAs interface. Our device beats the best-performing p-GaSb nanowire
metal-oxide-semiconductor field effect transistor (MOSFET), giving a typical
sub-threshold swing of 62 mV/dec, within 4% of the thermal limit, on-off ratio
, on-resistance ~700 k, contact resistance ~30 k,
peak transconductance 1.2 S/m and high-fidelity ac operation at
frequencies up to 10 kHz. The device consists of a GaAs nanowire with an
undoped core and heavily Be-doped shell. We carefully etch back the nanowire at
the gate locations to obtain Schottky-barrier insulated gates whilst leaving
the doped shell intact at the contacts to obtain low contact resistance. Our
device opens a path to all-GaAs nanowire MESFET complementary circuits with
simplified fabrication and improved performance
A Semiconductor Nanowire-Based Superconducting Qubit
We introduce a hybrid qubit based on a semiconductor nanowire with an
epitaxially grown superconductor layer. Josephson energy of the transmon-like
device ("gatemon") is controlled by an electrostatic gate that depletes
carriers in a semiconducting weak link region. Strong coupling to an on-chip
microwave cavity and coherent qubit control via gate voltage pulses is
demonstrated, yielding reasonably long relaxation times (0.8 {\mu}s) and
dephasing times (1 {\mu}s), exceeding gate operation times by two orders of
magnitude, in these first-generation devices. Because qubit control relies on
voltages rather than fluxes, dissipation in resistive control lines is reduced,
screening reduces crosstalk, and the absence of flux control allows operation
in a magnetic field, relevant for topological quantum information
Transport and Strong-Correlation Phenomena in Carbon Nanotube Quantum Dots in a Magnetic Field
Transport through carbon nanotube (CNT) quantum dots (QDs) in a magnetic
field is discussed. The evolution of the system from the ultraviolet to the
infrared is analyzed; the strongly correlated (SC) states arising in the
infrared are investigated. Experimental consequences of the physics are
presented -- the SC states arising at various fillings are shown to be
drastically different, with distinct signatures in the conductance and, in
particular, the noise. Besides CNT QDs, our results are also relevant to double
QD systems.Comment: 5 pages, 5 figure
Migrating to Cloud-Native Architectures Using Microservices: An Experience Report
Migration to the cloud has been a popular topic in industry and academia in
recent years. Despite many benefits that the cloud presents, such as high
availability and scalability, most of the on-premise application architectures
are not ready to fully exploit the benefits of this environment, and adapting
them to this environment is a non-trivial task. Microservices have appeared
recently as novel architectural styles that are native to the cloud. These
cloud-native architectures can facilitate migrating on-premise architectures to
fully benefit from the cloud environments because non-functional attributes,
like scalability, are inherent in this style. The existing approaches on cloud
migration does not mostly consider cloud-native architectures as their
first-class citizens. As a result, the final product may not meet its primary
drivers for migration. In this paper, we intend to report our experience and
lessons learned in an ongoing project on migrating a monolithic on-premise
software architecture to microservices. We concluded that microservices is not
a one-fit-all solution as it introduces new complexities to the system, and
many factors, such as distribution complexities, should be considered before
adopting this style. However, if adopted in a context that needs high
flexibility in terms of scalability and availability, it can deliver its
promised benefits
Parity lifetime of bound states in a proximitized semiconductor nanowire
Quasiparticle excitations can compromise the performance of superconducting
devices, causing high frequency dissipation, decoherence in Josephson qubits,
and braiding errors in proposed Majorana-based topological quantum computers.
Quasiparticle dynamics have been studied in detail in metallic superconductors
but remain relatively unexplored in semiconductor-superconductor structures,
which are now being intensely pursued in the context of topological
superconductivity. To this end, we introduce a new physical system comprised of
a gate-confined semiconductor nanowire with an epitaxially grown superconductor
layer, yielding an isolated, proximitized nanowire segment. We identify
Andreev-like bound states in the semiconductor via bias spectroscopy, determine
the characteristic temperatures and magnetic fields for quasiparticle
excitations, and extract a parity lifetime (poisoning time) of the bound state
in the semiconductor exceeding 10 ms.Comment: text and supplementary information combine
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