4,545 research outputs found

    Some Aspects of Classical and Quantum Phases

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    We study classical and quantum phases in the adiabatic Born-Oppenheimer context. These include a classical astronomical case, the general dual description of the phases, a new "Paradox" connected to scattering Berry phase and its resolution and various elaboration of topological/geometrical/non-abelian phases.Comment: 18 pages, 4 figure

    The stability of the O(N) invariant fixed point in three dimensions

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    We study the stability of the O(N) fixed point in three dimensions under perturbations of the cubic type. We address this problem in the three cases N=2,3,4N=2,3,4 by using finite size scaling techniques and high precision Monte Carlo simulations. It is well know that there is a critical value 2<Nc<42<N_c<4 below which the O(N) fixed point is stable and above which the cubic fixed point becomes the stable one. While we cannot exclude that Nc<3N_c<3, as recently claimed by Kleinert and collaborators, our analysis strongly suggests that NcN_c coincides with 3.Comment: latex file of 18 pages plus three ps figure

    Unique Transcriptional Profile of Sustained Ligand-Activated Preconditioning in Pre- and Post-Ischemic Myocardium

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    BACKGROUND: Opioidergic SLP (sustained ligand-activated preconditioning) induced by 3–5 days of opioid receptor (OR) agonism induces persistent protection against ischemia-reperfusion (I-R) injury in young and aged hearts, and is mechanistically distinct from conventional preconditioning responses. We thus applied unbiased gene-array interrogation to identify molecular effects of SLP in pre- and post-ischemic myocardium. METHODOLOGY/PRINCIPAL FINDINGS: Male C57Bl/6 mice were implanted with 75 mg morphine or placebo pellets for 5 days. Resultant SLP did not modify cardiac function, and markedly reduced dysfunction and injury in perfused hearts subjected to 25 min ischemia/45 min reperfusion. Microarray analysis identified 14 up- and 86 down-regulated genes in normoxic hearts from SLP mice (≥1.3-fold change, FDR≤5%). Induced genes encoded sarcomeric/contractile proteins (Myh7, Mybpc3,Myom2,Des), natriuretic peptides (Nppa,Nppb) and stress-signaling elements (Csda,Ptgds). Highly repressed genes primarily encoded chemokines (Ccl2,Ccl4,Ccl7,Ccl9,Ccl13,Ccl3l3,Cxcl3), cytokines (Il1b,Il6,Tnf) and other proteins involved in inflammation/immunity (C3,Cd74,Cd83, Cd86,Hla-dbq1,Hla-drb1,Saa1,Selp,Serpina3), together with endoplasmic stress proteins (known: Dnajb1,Herpud1,Socs3; putative: Il6, Gadd45g,Rcan1) and transcriptional controllers (Egr2,Egr3, Fos,Hmox1,Nfkbid). Biological themes modified thus related to inflammation/immunity, together with cellular/cardiovascular movement and development. SLP also modified the transcriptional response to I-R (46 genes uniquely altered post-ischemia), which may influence later infarction/remodeling. This included up-regulated determinants of cellular resistance to oxidant (Mgst3,Gstm1,Gstm2) and other forms of stress (Xirp1,Ankrd1,Clu), and repression of stress-response genes (Hspa1a,Hspd1,Hsp90aa,Hsph1,Serpinh1) and Txnip. CONCLUSIONS: Protection via SLP is associated with transcriptional repression of inflammation/immunity, up-regulation of sarcomeric elements and natriuretic peptides, and modulation of cell stress, growth and development, while conventional protective molecules are unaltered

    A review of the decoherent histories approach to the arrival time problem in quantum theory

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    We review recent progress in understanding the arrival time problem in quantum mechanics, from the point of view of the decoherent histories approach to quantum theory. We begin by discussing the arrival time problem, focussing in particular on the role of the probability current in the expected classical solution. After a brief introduction to decoherent histories we review the use of complex potentials in the construction of appropriate class operators. We then discuss the arrival time problem for a particle coupled to an environment, and review how the arrival time probability can be expressed in terms of a POVM in this case. We turn finally to the question of decoherence of the corresponding histories, and we show that this can be achieved for simple states in the case of a free particle, and for general states for a particle coupled to an environment.Comment: 10 pages. To appear in DICE 2010 conference proceeding

    Cognition-Enhancing Drugs: Can We Say No?

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    Normative analysis of cognition-enhancing drugs frequently weighs the liberty interests of drug users against egalitarian commitments to a level playing field. Yet those who would refuse to engage in neuroenhancement may well find their liberty to do so limited in a society where such drugs are widespread. To the extent that unvarnished emotional responses are world-disclosive, neurocosmetic practices also threaten to provide a form of faulty data to their users. This essay examines underappreciated liberty-based and epistemic rationales for regulating cognition-enhancing drugs

    One-loop Beta Functions for the Orientable Non-commutative Gross-Neveu Model

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    We compute at the one-loop order the beta-functions for a renormalisable non-commutative analog of the Gross Neveu model defined on the Moyal plane. The calculation is performed within the so called x-space formalism. We find that this non-commutative field theory exhibits asymptotic freedom for any number of colors. The beta-function for the non-commutative counterpart of the Thirring model is found to be non vanishing.Comment: 16 pages, 9 figure

    Gravitating defects of codimension-two

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    Thin gravitating defects with conical singularities in higher codimensions and with generalized Israel matching conditions are known to be inconsistent for generic energy-momentum. A way to remove this inconsistency is proposed and is realized for an axially symmetric gravitating codimension-two defect in six dimensional Einstein gravity. By varying with respect to the brane embedding fields, alternative matching conditions are derived, which are generalizations of the Nambu-Goto equations of motion of the defect, consistent with bulk gravity. For a maximally symmetric defect the standard picture is recovered. The four-dimensional perfect fluid cosmology coincides with conventional FRW in the case of radiation, but for dust it has rho^{4/3} instead of rho. A four-dimensional black hole solution is presented having the Schwarzschild form with a short-distance correction r^{-2}.Comment: Minor changes, to appear in Classical and Quantum Gravit

    Language of Lullabies: The Russification and De-Russification of the Baltic States

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    This article argues that the laws for promotion of the national languages are a legitimate means for the Baltic states to establish their cultural independence from Russia and the former Soviet Union
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