Si estireu fort ... ella caurà : Bellaterra 76

Fotografia de J. Moya-Angeler del concert de Lluís Llach al Campus de Bellaterra el 197

A model with shortage of places for educational and manpower systems

If in a system the size of some grades either has or is going to outgrow some desired value, it will be necessary to impose some restraints, in the form of capacity limits, to the size of the grades. In this paper a stochastic model in discrete time for such kind of educational and manpower systems is developed. Here, the flow of people to some grades will not be determined by the number of people able to be promoted or recruited, but by the number of vacancies in such grades. A set of equations is derived to obtain the equilibrium structure of such systems. A new technique is explained for treating steady-state control through recruitment in a Markov system.

Symptomatic osteonecrosis as a treatment complication in Hodgkin lymphoma: an analysis of the German Hodgkin Study Group (GHSG)

The majority of patients with Hodgkin Lymphoma (HL) can be cured with stage and risk adapted treatment today. Therefore, current research focuses on reducing long-term sequelae of treatment. Osteonecrosis (ON) is a severe long-term complication of HL treatment which has so far not been systematically evaluated. Hence, we investigated incidence, risk factors and timing of symptomatic ON in HL patients. Further endpoints included localization, intervention and outcome of ON. We included all qualified HL patients of the randomized German Hodgkin Study Group trials HD10-15 and HD18, recruited between 05/1998 and 07/2014 and aged from 16 to 60 years. Among 11 330 patients, 66 developed symptomatic ON after first-line treatment, 83.3% within three years. The incidence of symptomatic ON was 0.2% in early-stage HL and 1.0% in advanced-stage HL. Logistic regression revealed the total cumulative corticosteroid dose to be a strong risk factor interacting with younger age. Male sex additionally increased the risk of symptomatic ON. The prognostic value of the corresponding logistic regression model was rather high (AUC = 0.78). Other tested potential risk factors including obesity, IPS and radiotherapy did not further increase the risk of ON. Further development of current treatment protocols should aim to reduce the cumulative corticosteroid dose