Thoracic aortic aneurysm and atrial fibrillation: clinical associations with the risk of stroke from a global federated health network analysis

Background: An association with aortic aneurysm has been reported among patients with atrial fibrillation (AF). The aims of this study were to investigate the prevalence of thoracic aorta aneurysm (TAA) among patients with AF and to assess whether the co-presence of TAA is associated with a higher risk of adverse clinical outcomes. Methods and results: Using TriNetX, a global federated health research network of anonymised electronic medical records, all adult patients with AF, were categorised into two groups based on the presence of AF and TAA or AF alone. Between 1 January 2017 and 1 January 2019, 874,212 people aged ≥ 18 years with AF were identified. Of these 17,806 (2.04%) had a TAA. After propensity score matching (PSM), 17,805 patients were included in each of the two cohorts. During the 3 years of follow-up, 3079 (17.3%) AF patients with TAA and 2772 (15.6%) patients with AF alone, developed an ischemic stroke or transient ischemic attack (TIA). The risk of ischemic stroke/TIA was significantly higher in patients with AF and TAA (HR 1.09, 95% CI 1.04–1.15; log-rank p value < 0.001) The risk of major bleeding was higher in patients with AF and TAA (OR 1.07, 95% CI 1.01–1.14), but not significant in time-dependent analysis (HR 1.04, 95% CI 0.98–1.10; log-rank p value = 0.187), Conclusion: This retrospective analysis reports a clinical concomitance of the two medical conditions, and shows in a PSM analysis an increased risk of ischemic events in patients affected by TAA and AF compared to AF alone

Seven years experience with rapid deployment Edwards Intuity aortic prosthesis

© 2020 Sociedad Española de Cirugía Cardiovascular y Endovascular. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ This document is the Published version of a Published Work that appeared in final form in Cirugía Cardiovascular. To access the final edited and published work see https://doi.org/10.1016/j.circv.2020.08.002Introducción Las prótesis aorticas de rápido despliegue aparecieron hace 10 años para tratar la estenosis aórtica. El sistema de válvula Edwards Intuity es una prótesis biológica basada en la válvula Edwards Magna con un marco infraanular. Presentamos los resultados clínicos y hemodinámicos a corto y largo plazo obtenidos con esta prótesis biológica. Métodos Ciento diecisiete pacientes (65% varones, 75 ± 4,5 años) con estenosis aórtica (gradiente medio preoperatorio de 49,6 ± 12 mm Hg) recibieron una prótesis Edwards Intuity entre septiembre de 2012 y diciembre de 2019. Se incluyeron en una base de datos prospectiva que recogía diferentes variables. La media de seguimiento fue de 36 ± 21 meses. Resultados Mortalidad hospitalaria del 3,4%, supervivencia al año, a los 3 y 6 años del 95%, 90% y 81%, respectivamente. Se utilizó hemiesternotomía media superior en 78 pacientes (67%). La mediana de tiempos de isquemia miocárdica y de circulación extracorpórea de toda la serie fueron 40 (33-50) minutos y 59 (48-73) minutos. Gradientes medios al alta, al año y a los 2 años fueron 10 ± 4 mm, 9 ± 3,5 mm y 8,4 ± 3,4 mm Hg. Ocho pacientes (7%) necesitaron marcapasos en el postoperatorio. Dos pacientes (0,6%) se reintervinieron en seguimiento por endocarditis y otro (0,3%) se reintervino por fuga periprotésica. Conclusión El sistema de válvula Edwards Intuity presenta buenos resultados clínicos y hemodinámicos a corto y largo plazo. Estas prótesis aórticas se pueden considerar una alternativa a las prótesis convencionales, sobre todo en cirugía de mínimo acceso y en intervenciones complejas.----------------Introduction Rapid deployment aortic valves appeared ten years ago to treat aortic stenosis. The Edwards Intuity Valve System is a biological prosthesis based on the Edwards Magna valve with an infra-annular framework. We present the short and long-term clinical and hemodynamic results obtained with this biological prosthesis. Methods One hundred seventeen patients (65% male, 75 ± 4.5 years) with aortic stenosis (mean preoperative gradient of 49.6 ± 12 mm Hg) received an Edwards Intutiy prosthesis between September 2012 and December 2019. They were included in a prospective data base that collected different variables. The mean follow-up was 36 ± 21 months. Results Hospital mortality of 3.4%. Survival at one, three and six years of 95%, 90% and 81%, respectively. Upper hemisternotomy was used in 78 patients (67%). The median times of myocardial ischemia and extracorporeal circulation for the entire series were 40 (33-50) minutes and 59 (48-73) minutes. Average gradients at discharge, one year and two years were 10 ± 4 mm, 9 ± 3.5 mm and 8.4 ± 3.4 mm Hg. Eight patients (7%) required pacemakers in the postoperative period. Two patients (0.6%) underwent surgery for endocarditis and another (0.3%) underwent surgery for periprosthetic leak. Conclusion The Edwards Intutiy valve system presents good short and long term clinical and hemodynamic results. These aortic prostheses can be considered an alternative to conventional prostheses, especially in minimal access surgery and in complex interventions

Search for Bc+→π+μ+μ−B_c^+\to\pi^+\mu^+\mu^- decays and measurement of the branching fraction ratio B(Bc+→ψ(2S)π+)/B(Bc+→J/ψπ+){\cal B}(B_c^+\to\psi(2S)\pi^+)/{\cal B}(B_c^+\to J/\psi \pi^+)

The first search for nonresonant $B_c^+\to\pi^+\mu^+\mu^-$ decays is reported. The analysis uses proton-proton collision data collected with the LHCb detector between 2011 and 2018, corresponding to an integrated luminosity of 9 fb$^{-1}$. No evidence for an excess of signal events over background is observed and an upper limit is set on the branching fraction ratio ${\cal B}(B_c^+\to\pi^+\mu^+\mu^-)/{\cal B}(B_c^+\to J/\psi \pi^+) < 2.1\times 10^{-4}$ at $90\%$ confidence level. Additionally, an updated measurement of the ratio of the $B_c^+\to\psi(2S)\pi^+$ and $B_c^+\to J/\psi \pi^+$ branching fractions is reported. The ratio ${\cal B}(B_c^+\to\psi(2S)\pi^+)/{\cal B}(B_c^+\to J/\psi \pi^+)$ is measured to be $0.254\pm 0.018 \pm 0.003 \pm 0.005$, where the first uncertainty is statistical, the second systematic, and the third is due to the uncertainties on the branching fractions of the leptonic $J/\psi$ and $\psi(2S)$ decays. This measurement is the most precise to date and is consistent with previous LHCb results.Comment: All figures and tables, along with machine-readable versions and any supplementary material and additional information, are available at https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2023-037.html (LHCb public pages

Search for the lepton-flavor violating decay Bs0 →φμ±τ

A search for the lepton-flavor violating decays Bs0→φμ±τ is presented, using a sample of proton-proton collisions at center-of-mass energies of 7, 8, and 13 TeV, collected with the LHCb detector and corresponding to a total integrated luminosity of 9 fb-1. The τ leptons are selected using decays with three charged pions. No significant excess is observed, and an upper limit on the branching fraction is determined to be B(Bs0→φμ±τ)&lt;1.0×10-5 at 90% confidence level

Probing the nature of the χc1(3872)\chi_{c1}(3872) state using radiative decays

The radiative decays $\chi_{c1}(3872)\rightarrow\psi(2S)\gamma$ and $\chi_{c1}(3872)\rightarrow J/\psi\gamma$ are used to probe the~nature of the~$\chi_{c1}(3872)$ state using proton-proton collision data collected with the LHCb detector, corresponding to an~integrated luminosity of~9fb$^{-1}$. Using the~$B^+\rightarrow \chi_{c1}(3872)K^+$decay, the $\chi_{c1}(3872)\rightarrow \psi(2S)\gamma$ process is observed for the first time and the ratio of its partial width to that of the $\chi_{c1}(3872)\rightarrow J/\psi\gamma$ decay is measured to be $$\frac{\Gamma_{\chi_{c1}(3872)\rightarrow \psi(2S)\gamma}} {\Gamma_{\chi_{c1}(3872)\rightarrow J/\psi\gamma}} = 1.67 \pm 0.21 \pm 0.12 \pm0.04 ,$$ where the first uncertainty is statistical, the second systematic and the third is due to the uncertainties on the branching fractions of the $\psi(2S)$ and $J/\psi$ mesons. The measured ratio makes the interpretation of the $\chi_{c1}(3872)$ state as a~pure $D^0\bar{D}^{*0}+\bar{D}^0D^{*0}$ molecule questionable and strongly indicates a sizeable compact charmonium or tetraquark component within the $\chi_{c1}(3872)$ state.Comment: 31 pages, 2 figures. All figures and tables, along with any supplementary material and additional information, are available at https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2024-015.html (LHCb public pages

Measurement of the branching fraction ratios R(D+)R(D^{+}) and R(D∗+)R(D^{*+}) using muonic τ\tau decays

The branching fraction ratios of $\overline{B}^0\to D^+\tau^-\overline{\nu}_{\tau}$ and $\overline{B}^0\to D^{*+}\tau^-\overline{\nu}_{\tau}$ decays are measured with respect to their muonic counterparts, using a data sample corresponding to an integrated luminosity of 2.0 fb$^{-1}$ collected by the LHCb experiment in proton-proton collisions at $\sqrt{s} = 13$ TeV. The reconstructed final states are formed by combining $D^+$ mesons with $\tau^-\to\mu^-\overline{\nu}_{\mu}\nu_{\tau}$ candidates, where the $D^+$ is reconstructed via the $D^+\to K^-\pi^+\pi^+$ decay. The results are \begin{align*} R(D^{+}) &= 0.249 \pm 0.043 \pm 0.047, R(D^{*+}) &= 0.402 \pm 0.081\pm 0.085, \end{align*} where the first uncertainties are statistical and the second systematic. The two measurements have a correlation coefficient of $-0.39$ and are compatible with the Standard Model.Comment: All figures and tables, along with machine-readable versions and any supplementary material and additional information, are available at https://lhcbproject.web.cern.ch/Publications/LHCbProjectPublic/LHCb-PAPER-2024-007.html (LHCb public pages

Search for the rare decay of charmed baryon Λc+ into the pμ+μ- final state

A search for the nonresonant Λc+→pμ+μ- decay is performed using proton-proton collision data recorded at a center-of-mass energy of 13 TeV by the LHCb experiment, corresponding to an integrated luminosity of 5.4 fb-1. No evidence for the decay is found in the dimuon invariant-mass regions where the expected contributions of resonances is subdominant. The upper limit on the branching fraction of the Λc+→pμ+μ- decay is determined to be 2.9(3.2)×10-8 at 90%(95%) confidence level. The branching fractions in the dimuon invariant-mass regions dominated by the η, ρ and ω resonances are also determined

Amplitude analysis of the Λb0→pK−γ decay

The resonant structure of the radiative decay Λb0→pK−γ in the region of proton-kaon invariant-mass up to 2.5 GeV/c2 is studied using proton-proton collision data recorded at centre-of-mass energies of 7, 8, and 13 TeV collected with the LHCb detector, corresponding to a total integrated luminosity of 9 fb−1. Results are given in terms of fit and interference fractions between the different components contributing to this final state. Only Λ resonances decaying to pK− are found to be relevant, where the largest contributions stem from the Λ(1520), Λ(1600), Λ(1800), and Λ(1890) states

Measurement of D0−D‾0D^0-\overline{D}^0 mixing and search for CPCP violation with D0→K+π−D^0\rightarrow K^+\pi^- decays

A measurement of the time-dependent ratio of the $D^0\rightarrow K^+\pi^-$ to $\overline{D}^0\rightarrow K^+\pi^-$ decay rates is reported. The analysis uses a sample of proton-proton collisions corresponding to an integrated luminosity of 6 fb$^-1$ recorded by the LHCb experiment from 2015 through 2018 at a center-of-mass energy of 13 TeV. The $D^0$ meson is required to originate from a $D^{*+}\rightarrow D^0\pi^+$ decay, such that its flavor at production is inferred from the charge of the accompanying pion. The measurement is performed simultaneously for the $K^+\pi^-$ and $K^-\pi^+$ final states, allowing both mixing and $CP$-violation parameters to be determined. The value of the ratio of the decay rates at production is determined to be $R_{K\pi} = (343.1 \pm 2.0) \times 10^{-5}$. The mixing parameters are measured to be $c_{K\pi} = (51.4 \pm 3.5) \times 10^{-4}$ and $c_{K\pi}^{\prime} = (13 \pm 4) \times 10^{-6}$, where $\sqrt{R_{K\pi}}c_{K\pi}$ is the linear coefficient of the expansion of the ratio as a function of decay time in units of the $D^0$ lifetime, and $c_{K\pi}^{\prime}$ is the quadratic coefficient, both averaged between the $K^+\pi^-$ and $K^-\pi^+$ final states. The precision is improved relative to the previous best measurement by approximately 60%. No evidence for $CP$ violation is found.Comment: All figures and tables, along with machine-readable versions and any supplementary material and additional information, are available at https://lhcbproject.web.cern.ch/Publications/LHCbProjectPublic/LHCb-PAPER-2024-008.htm

Observation of Exotic J/ψφ Resonant Structure in Diffractive Processes in Proton-Proton Collisions

The first study of J/ψφ production in diffractive processes in proton-proton collisions is presented. The study is based on an LHCb dataset recorded at center-of-mass energy of 13 TeV, corresponding to an integrated luminosity of 5 fb-1. The data disfavor a nonresonant J/ψφ production but are consistent with a resonant model including several resonant states observed previously only in B+→J/ψφK+ decays. The χc0(4500) state is observed with a significance over 6σ and the χc1(4274) is confirmed with a significance of more than 4σ