The Blood Neutrophil Count After 1 Month of Treatment Predicts the Radiologic Severity of Lung Disease at Treatment End

BACKGROUND: Post-tuberculous lung disease confers significant morbidity. However, the determinants of persistent lung damage in tuberculosis are not well established. We investigated associations between tuberculosis-associated radiological changes and socio-demographic factors, surrogates of bacillary burden and blood inflammatory markers at initiation of therapy and after 1 month. RESEARCH QUESTION: What are the predictors of radiological severity at the end of tuberculosis treatment for tuberculosis? STUDY DESIGN AND METHODS: We collected data from patients treated for drug sensitive pulmonary tuberculosis at our centre over a 5.5-year period. We recorded age, sex, ethnicity, smoking status, symptom duration, sputum smear grade, time to culture positivity and blood results (C-reactive protein and neutrophil count) at baseline and after 1 month of treatment. Chest x-rays performed at baseline, 2 months and end of treatment were assessed independently by two radiologists and scored using a validated system. Relationships between predictor variables and radiological outcomes were assessed using linear or binary logistic regression. RESULTS: We assessed 154 individuals, mean age 37 years, 63% male. In multivariate analysis, baseline radiological severity correlated with sputum smear grade (p=0.003) and neutrophil count (p<0.001). At end of treatment, only the 1-month neutrophil count was significantly associated with overall radiological severity in multivariate analysis (r=0.34, p=0.003), and remained significant after controlling for baseline radiological scores. The 1-month neutrophil count was also the only independent correlate of volume loss and pleural thickening at end of treatment and was significantly higher in patients with persistent cavitation or effusion versus those without. INTERPRETATION: Persistent neutrophilic inflammation after 1 month of tuberculosis therapy is associated with poor radiological outcome, suggesting a target for interventions to minimise post-tuberculous lung disease

Evolution of the Cluster X-ray Luminosity Function

We report measurements of the cluster X-ray luminosity function out to z=0.8 based on the final sample of 201 galaxy systems from the 160 Square Degree ROSAT Cluster Survey. There is little evidence for any measurable change in cluster abundance out to z~0.6 at luminosities less than a few times 10^44 ergs/s (0.5-2.0 keV). However, between 0.6 < z < 0.8 and at luminosities above 10^44 ergs/s, the observed volume densities are significantly lower than those of the present-day population. We quantify this cluster deficit using integrated number counts and a maximum-likelihood analysis of the observed luminosity-redshift distribution fit with a model luminosity function. The negative evolution signal is >3 sigma regardless of the adopted local luminosity function or cosmological framework. Our results and those from several other surveys independently confirm the presence of evolution. Whereas the bulk of the cluster population does not evolve, the most luminous and presumably most massive structures evolve appreciably between z=0.8 and the present. Interpreted in the context of hierarchical structure formation, we are probing sufficiently large mass aggregations at sufficiently early times in cosmological history where the Universe has yet to assemble these clusters to present-day volume densities.Comment: 15 pages, 10 figures, accepted for publication in Ap

Chandra Discovery of a 300 kpc X-ray Jet in the GPS Quasar PKS1127-145

We have discovered an X-ray jet with Chandra imaging of the z=1.187 radio-loud quasar PKS1127-145. In this paper we present the Chandra X-ray data, follow-up VLA observations, and optical imaging using the HST WFPC2. The X-ray jet contains 273+/-5 net counts in 27ksec and extends ~30 arcsec, from the quasar core, corresponding to a minimum projected linear size of ~330/h_50 kpc. The evaluation of the X-ray emission processes is complicated by the observed offsets between X-ray and radio brightness peaks. We discuss the problems posed by these observations to jet models. In addition, PKS1127-145 is a Giga-Hertz Peaked Spectrum radio source, a member of the class of radio sources suspected to be young or ``frustrated'' versions of FRI radio galaxies. However the discovery of an X-ray and radio jet extending well outside the host galaxy of PKS1127-145 suggests that activity in this and other GPS sources may be long-lived and complex.Comment: 22 pages, 11 ps figures, 1 figure in a JPG file, 3 tables. AASTEX. Accepted by The Astrophysical Journa

GTI-space : the space of generalized topological indices

A new extension of the generalized topological indices (GTI) approach is carried out torepresent 'simple' and 'composite' topological indices (TIs) in an unified way. Thisapproach defines a GTI-space from which both simple and composite TIs represent particular subspaces. Accordingly, simple TIs such as Wiener, Balaban, Zagreb, Harary and Randićconnectivity indices are expressed by means of the same GTI representation introduced for composite TIs such as hyper-Wiener, molecular topological index (MTI), Gutman index andreverse MTI. Using GTI-space approach we easily identify mathematical relations between some composite and simple indices, such as the relationship between hyper-Wiener and Wiener index and the relation between MTI and first Zagreb index. The relation of the GTI space with the sub-structural cluster expansion of property/activity is also analysed and some routes for the applications of this approach to QSPR/QSAR are also given

The warm absorber in NGC 5548: The lean years

We study the variability of the warm absorber and the gas responsible for the emission lines in the Seyfert 1 galaxy NGC 5548, in order to constrain the location and physical properties of these components. Using X-ray spectra taken with the \textit{Chandra}$-$LETGS in 2002 and 2005, we study variability in the ionic column densities and line intensities. We find a lower \ion{O}{vii} forbidden emission line flux in 2005, while the Fe K$\alpha$ line flux stays constant. The warm absorber is less ionized in 2005, allowing us to constrain its location to within 7 pc of the central source. Using both the observed variability and the limit on the FWHM of the \ion{O}{vii} f line, we have constrained the location of the narrow line region to a distance of 1 pc from the central source. The apparent lack of variability of the Fe K$\alpha$ line flux does not allow for a unique explanation.Comment: 6 pages, 6 figures, accepted by A&

Constraining dark energy with Sunyaev-Zel'dovich cluster surveys

We discuss the prospects of constraining the properties of a dark energy component, with particular reference to a time varying equation of state, using future cluster surveys selected by their Sunyaev-Zel'dovich effect. We compute the number of clusters expected for a given set of cosmological parameters and propogate the errors expected from a variety of surveys. In the short term they will constrain dark energy in conjunction with future observations of type Ia supernovae, but may in time do so in their own right.Comment: 5 pages, 3 figures, 1 table, version accepted for publication in PR

Cortical tau is associated with microstructural imaging biomarkers of neurite density and dendritic complexity in Alzheimer's disease

INTRODUCTION: In Alzheimer's disease (AD), hyperphosphorylated tau is closely associated with focal neurodegeneration, but the mechanism remains uncertain. METHODS: We quantified cortical microstructure using neurite orientation dispersion and density imaging in 14 individuals with young onset AD. Diffusion tensor imaging measured mean diffusivity (MD). Amyloid beta and tau positron emission tomography were acquired and associations with microstructural measures were assessed. RESULTS: When regional volume was adjusted for, in the medial temporal lobe there was a significant negative association between neurite density and tau (partial R2  = 0.56, p = 0.008) and between orientation dispersion and tau (partial R2  = 0.66, p = 0.002), but not between MD and tau. In a wider cortical composite, there was an association between orientation dispersion and tau (partial R2  = 0.43, p = 0.030), but not between other measures and tau. DISCUSSION: Our findings are consistent with tau causing first dendritic pruning (reducing dispersion/complexity) followed by neuronal loss. Advanced magnetic resonance imaging (MRI) microstructural measures have the potential to provide information relating to underlying tau deposition

Geographically touring the eastern bloc: British geography, travel cultures and the Cold War

This paper considers the role of travel in the generation of geographical knowledge of the eastern bloc by British geographers. Based on oral history and surveys of published work, the paper examines the roles of three kinds of travel experience: individual private travels, tours via state tourist agencies, and tours by academic delegations. Examples are drawn from across the eastern bloc, including the USSR, Poland, Romania, East Germany and Albania. The relationship between travel and publication is addressed, notably within textbooks, and in the Geographical Magazine. The study argues for the extension of accounts of cultures of geographical travel, and seeks to supplement the existing historiography of Cold War geography