1,445 research outputs found
Advances in the Diagnosis and Management of Well-Differentiated Neuroendocrine Neoplasms
Neuroendocrine neoplasms constitute a diverse group of tumors that derive from the sensory and secretory neuroendocrine cells and predominantly arise within the pulmonary and gastrointestinal tracts. The majority of these neoplasms have a well-differentiated grade and are termed neuroendocrine tumors (NETs). This subgroup is characterized by limited proliferation and patients affected by these tumors carry a good to moderate prognosis. A substantial subset of patients presenting with a NET suffer from the consequences of endocrine syndromes as a result of the excessive secretion of amines or peptide hormones, which can impair their quality of life and prognosis. Over the past 15 years, critical developments in tumor grading, diagnostic biomarkers, radionuclide imaging, randomized controlled drug trials, evidence-based guidelines, and superior prognostic outcomes have substantially altered the field of NET care. Here, we review the relevant advances to clinical practice that have significantly upgraded our approach to NET patients, both in diagnostic and in therapeutic options
The XMM-Newton view of the Crab
Aims. We discuss the current X-ray view of the Crab Nebula and Pulsar, summarising our analysis of observations of the source with the EPIC-pn camera on board the XMM-Newton observatory. Different modes of EPIC-pn were combined in order to yield a complete scenario of the spectral properties of the Crab resolved in space and time (pulse phase). In addition we give a description of the special
EPIC-pn Burst mode and guidance for data reduction in that mode.
Methods. We analysed spectra for the nebula and pulsar separately in the 0.6â12.0 keV energy band. All data were processed with the
SAS 6.0.0 XMM-Newton Scientific Analysis System package; models were fitted to the data with XSPEC 11. The high time resolution of EPIC-pn in its Burst mode (7 ÎŒs) was used for a phase resolved analysis of the pulsar spectrum, after determination of the period with epoch folding techniques. Data from the SmallWindow mode were processed and corrected for pile-up allowing for spectroscopy
simultaneously resolved in space and time.
Results. The spatial variation of the spectrum over the entire region of the Crab shows a gradual spectral softening from the inner pulsar region to the outer nebula region with a variation in photon index, Î, from 2.0 to 2.4. Pulse phase resolved spectroscopy of the Crab Pulsar reveals a phase dependent modulation of the photon index in form of a significant hardening of the spectrum in the
inter-peak phase from Î = 1.7 during the pulse peak to Î = 1.5
Study on the large-displacement behaviour of a spiral spring with variations of cross-section, orthotropy and prestress
This work is dedicated to the study of the large-displacement behaviour of a
spiral spring. Parameters that influence the local torsion stiffness of the
beam that constitutes the spiral are varied and their effect is studied.
Cross-sectional shape, orthotropic material orientation and prestress are the
three classes of parameters that are varied. The effect that the local change
in torsional stiffness has on the overall behaviour is illustrated in a
linearised way by comparing in-plane and out-of-plane stiffnesses, and
nonlinearly, by inspecting a graphical representation of the potential energy
field of the system. Several embodiments composed of multiple spirals are
showed to illustrate how the understanding of the nonlinear behaviour could
be exploited in conceptual design of compliant mechanisms.</p
Hyper-velocity impact test and simulation of a double-wall shield concept for the Wide Field Monitor aboard LOFT
The space mission LOFT (Large Observatory For X-ray Timing) was selected in
2011 by ESA as one of the candidates for the M3 launch opportunity. LOFT is
equipped with two instruments, the Large Area Detector (LAD) and the Wide Field
Monitor (WFM), based on Silicon Drift Detectors (SDDs). In orbit, they would be
exposed to hyper-velocity impacts by environmental dust particles, which might
alter the surface properties of the SDDs. In order to assess the risk posed by
these events, we performed simulations in ESABASE2 and laboratory tests. Tests
on SDD prototypes aimed at verifying to what extent the structural damages
produced by impacts affect the SDD functionality have been performed at the Van
de Graaff dust accelerator at the Max Planck Institute for Nuclear Physics
(MPIK) in Heidelberg. For the WFM, where we expect a rate of risky impacts
notably higher than for the LAD, we designed, simulated and successfully tested
at the plasma accelerator at the Technical University in Munich (TUM) a
double-wall shielding configuration based on thin foils of Kapton and
Polypropylene. In this paper we summarize all the assessment, focussing on the
experimental test campaign at TUM.Comment: Proc. SPIE 9144, Space Telescopes and Instrumentation 2014:
Ultraviolet to Gamma Ray, 91446
First Light Measurements with the XMM-Newton Reflection Grating Spectrometers: Evidence for an Inverse First Ionisation Potential Effect and Anomalous Ne A bundance in the Coronae of HR 1099
The RS CVn binary system HR 1099 was extensively observed by the XMM-Newton
observatory in February 2000 as its first-light target. A total of 570 ks of
exposure time was accumulated with the Reflection Grating Spectrometers (RGS).
The integrated X-ray spectrum between 5-35 Angstrom is of unprecedented quality
and shows numerous features attributed to transitions of the elements C, N, O,
Ne, Mg, Si, S, Fe, and Ni. We perform an in-depth study of the elemental
composition of the average corona of this system, and find that the elemental
abundances strongly depend on the first ionisation potential (FIP) of the
elements. But different from the solar coronal case, we find an inverse FIP
effect, i.e., the abundances (relative to oxygen) increase with increasing FIP.
Possible scenarios, e.g., selective enrichment due to Ne-rich flare-like
events, are discussed.Comment: 5 pages, 4 figures. Accepted by A&A Letters, XMM issu
Search for gammaâray emission from AGN with COMPTEL
The COMPTEL data (âŒ0.7â30 MeV) were searched for emission from AGN. Four sources have been detected so far: the quasars 3C 273, 3C 279, PKS 0528+134, and the radio galaxy Centaurus A. 3C 273 and 3C 279 were detected in CGRO observation period 3 with quite different spectral shapes. There is also evidence for 3C 273 at a weak flux level in observation period 11. The quasar PKS 0528+134 was detected above 3 MeV as part of a search for AGN already observed by EGRET. Cen A was seen up to 3 MeV by combining data from different observation periods
COMPTEL observations of the inner galaxy
This paper presents a first global study of COMPTEL observations of the inner Galaxy in the energy range 0.75â10 MeV. Preliminary findings demonstrate COMPTELâs capabilities for mapping the observed gamma radiation and disentangling the contributions from point sources and diffuse emission
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