A Dynamic Network Approach to Breakthrough Innovation

This paper outlines a framework for the study of innovation that treats discoveries as additions to evolving networks. As inventions enter they expand or limit the reach of the ideas they build on by influencing how successive discoveries use those ideas. The approach is grounded in novel measures of the extent to which an innovation amplifies or disrupts the status quo. Those measures index the effects inventions have on subsequent uses of prior discoveries. In so doing, they characterize a theoretically important but elusive feature of innovation. We validate our approach by showing it: (1) discriminates among innovations of similar impact in analyses of U.S. patents; (2) identifies discoveries that amplify and disrupt technology streams in select case studies; (3) implies disruptive patents decrease the use of their predecessors by 60% in difference-in-differences estimation; and, (4) yields novel findings in analyses of patenting at 110 U.S. universities.Comment: 37 pages, 3 figures, 5 table

The GeV-TeV Connection in Galactic gamma-ray sources

Recent observations with atmospheric Cherenkov telescope systems such as H.E.S.S. and MAGIC have revealed a large number of new sources of very-high-energy (VHE) gamma-rays from 100 GeV - 100 TeV, mostly concentrated along the Galactic plane. At lower energies (100 MeV - 10 GeV) the satellite-based instrument EGRET revealed a population of sources clustering along the Galactic Plane. Given their adjacent energy bands a systematic correlation study between the two source catalogues seems appropriate. Here, the populations of Galactic sources in both energy domains are characterised on observational as well as on phenomenological grounds. Surprisingly few common sources are found in terms of positional coincidence and spectral consistency. These common sources and their potential counterparts and emission mechanisms will be discussed in detail. In cases of detection only in one energy band, for the first time consistent upper limits in the other energy band have been derived. The EGRET upper limits are rather unconstraining due to the sensitivity mismatch to current VHE instruments. The VHE upper limits put strong constraints on simple power-law extrapolation of several of the EGRET spectra and thus strongly suggest cutoffs in the unexplored energy range from 10 GeV - 100 GeV. Physical reasons for the existence of cutoffs and for differences in the source population at GeV and TeV energies will be discussed. Finally, predictions will be derived for common GeV - TeV sources for the upcoming GLAST mission bridging for the first time the energy gap between current GeV and TeV instruments.Comment: (1) Kavli Institute for Particle Astrophysics and Cosmology (KIPAC), Stanford, USA (2) Stanford University, W.W. Hansen Experimental Physics Lab (HEPL) and KIPAC, Stanford, USA (3) ICREA & Institut de Ciencies de l'Espai (IEEC-CSIC) Campus UAB, Fac. de Ciencies, Barcelona, Spain. (4) School of Physics and Astronomy, University of Leeds, UK. Paper Submitted to Ap

An Overview of Modifications Applied to a Turbulence Response Analysis Method for Flexible Aircraft Configurations

A software program and associated methodology to study gust loading on aircraft exists for a classification of geometrically simplified flexible configurations. This program consists of a simple aircraft response model with two rigid and three flexible symmetric degrees of freedom and allows for the calculation of various airplane responses due to a discrete one-minus-cosine gust as well as continuous turbulence. Simplifications, assumptions, and opportunities for potential improvements pertaining to the existing software program are first identified, then a revised version of the original software tool is developed with improved methodology to include more complex geometries, additional excitation cases, and output data so as to provide a more useful and accurate tool for gust load analysis. Revisions are made in the categories of aircraft geometry, computation of aerodynamic forces and moments, and implementation of horizontal tail mode shapes. In order to improve the original software program to enhance usefulness, a wing control surface and horizontal tail control surface is added, an extended application of the discrete one-minus-cosine gust input is employed, a supplemental continuous turbulence spectrum is implemented, and a capability to animate the total vehicle deformation response to gust inputs in included. These revisions and enhancements are implemented and an analysis of the results is used to validate the modifications

Expression of the insulin-like growth factor-II/mannose-6-phosphate receptor in multiple human tissues during fetal life and early infancy

The insulin like growth factor-II/mannose-6-phosphate (IGF-II/M6P) receptor has been detected in many cells and tissues. In the rat, there is a dramatic developmental regulation of IGF-II/M6P receptor expression, the receptor being high in fetal and neonatal tissues and declining thereafter. We have systematically studied the expression of the human IGF-II/M6P receptor protein in tissues from 10 human fetuses and infants (age 23 weeks gestation to 24 months postnatal). We have asked 1) whether there is differential expression among different organs, and 2) whether or not the human IGF-II/M6P receptor is developmentally regulated from 23 weeks gestation to 24 months postnatal. Protein was extracted from human tissues using a buffer containing 2% sodium dodecyl sulfate and 2% Triton X-100. Aliquots of the protein extracts were analyzed by sodium dodecyl sulfate- polyacrylamide gel electrophoresis and immunoblotting using an anti-IGF- II/M6P receptor antiserum (no. 66416) and 125I-protein A or an immunoperoxidase stain. IGF-II/M6P receptor immunoreactivity was detected in all tissues studied with the highest amount of receptor being expressed in heart, thymus, and kidney and the lowest receptor content being measured in brain and muscle. The receptor content in ovary, testis, lung, and spleen was intermediate. The apparent molecular weight of the IGF-II/M6P receptor (220,000 kilos without reduction of disulfide bonds) varied among the different tissues: in brain the receptor was of lower molecular weight than in other organs. Immunoquantitation experiments employing 125I-protein A and protein extracts from human kidney at different ages revealed a small, albeit not significant, difference of the receptor content between fetal and postnatal tissues: as in other species, larger amounts of receptor seemed to be present in fetal than in postnatal organs. In addition, no significant difference of the receptor content between human fetal liver and early postnatal liver was measured employing 125I-protein A- immunoquantitation in three fetal and five postnatal liver tissue samples. The distribution of IGF-binding protein (IGEBP) species, another abundant and major class of IGF binding principles, was also measured in human fetal and early postnatal lung, liver, kidney, muscle, and brain using Western ligand blotting with 125I-IGF-II: as with IGF-II/M6P receptor immunoreactivity there was differential expression of the different classes of IGFBPs in the various organs