377 research outputs found
Calculation of Spectral Darkening and Visibility Functions for Solar Oscillations
Calculations of spectral darkening and visibility functions for the
brightness oscillations of the Sun resulting from global solar oscillations are
presented. This has been done for a broad range of the visible and infrared
continuum spectrum. The procedure for the calculations of these functions
includes the numerical computation of depth-dependent derivatives of the
opacity caused by p modes in the photosphere. A radiative-transport code was
used for this purpose to get the disturbances of the opacities from temperature
and density fluctuations. The visibility and darkening functions are obtained
for adiabatic oscillations under the assumption that the temperature
disturbances are proportional to the undisturbed temperature of the
photosphere. The latter assumption is the only way to explore any opacity
effects since the eigenfunctions of p-mode oscillations have not been obtained
so far. This investigation reveals that opacity effects have to be taken into
account because they dominate the violet and infrared part of the spectrum.
Because of this dominance, the visibility functions are negative for those
parts of the spectrum. Furthermore, the darkening functions show a
wavelength-dependent change of sign for some wavelengths owing to these opacity
effects. However, the visibility and darkening functions under the assumptions
used contradict the observations of global p-mode oscillations, but it is
beyond doubt that the opacity effects influence the brightness fluctuations of
the Sun resulting from global oscillations
Quantitative kinetics and enthalpy measurements of biphasic underflow chemical reactions by InfraRed Thermography
Abstract The scope of this paper is to present the experimental study of a well known chemical reaction in a biphasic millifluidic droplet flow by using InfraRed Thermography. This simple thermal evaluation enables the characterization of kinetics and enthalpy of exothermic chemical reactions. The originality of this work is the application of a very simple thermal model based on an homogenized thin body approximation to perform calorimetric estimations. This novel calorimeter needs a thermal calibration step to estimate the heat losses (W). Then, a correlation method is applied for the simultaneous estimation of the heat source (Ï) and the characteristic coefficient due the convective effects (H). Here the estimation of the characteristic coefficient H (s â1 ) is done at each flow rate ratio (R). This procedure is applied for several chemical reaction performed at different flow rate ratios. Then, the enthalpy is estimated with an error lower than 2%. In addition, the methodology to estimate the mixing kinetics of the reaction can be pointed out by the integrated flux over the time. Finally, a non contact thermal calorimeter based on millifluidic and IR thermography was developed. It is a convenient and powerful tool for the characterization of chemical reaction performed in a droplet flow
PHIL photoinjector test line
LAL is now equiped with its own platform for photoinjectors tests and
Research and Developement, named PHIL (PHotoInjectors at LAL). This facility
has two main purposes: push the limits of the photoinjectors performances
working on both the design and the associated technology and provide a low
energy (MeV) short pulses (ps) electron beam for the interested users. Another
very important goal of this machine will be to provide an opportunity to form
accelerator physics students, working in a high technology environment. To
achieve this goal a test line was realised equipped with an RF source, magnets
and beam diagnostics. In this article we will desrcibe the PHIL beamline and
its characteristics together with the description of the first two
photoinjector realised in LAL and tested: the ALPHAX and the PHIN RF Guns
Solar-like oscillations in the metal-poor subgiant nu Indi: II. Acoustic spectrum and mode lifetime
Convection in stars excites resonant acoustic waves which depend on the sound
speed inside the star, which in turn depends on properties of the stellar
interior. Therefore, asteroseismology is an unrivaled method to probe the
internal structure of a star. We made a seismic study of the metal-poor
subgiant star nu Indi with the goal of constraining its interior structure. Our
study is based on a time series of 1201 radial velocity measurements spread
over 14 nights obtained from two sites, Siding Spring Observatory in Australia
and ESO La Silla Observatory in Chile. The power spectrum of the high precision
velocity time series clearly presents several identifiable peaks between 200
and 500 uHz showing regularity with a large and small spacing of 25.14 +- 0.09
uHz and 2.96 +- 0.22 uHz at 330 uHz. Thirteen individual modes have been
identified with amplitudes in the range 53 to 173 cm/s. The mode damping time
is estimated to be about 16 days (1-sigma range between 9 and 50 days),
substantially longer than in other stars like the Sun, the alpha Cen system or
the giant xi Hya.Comment: 5 pages, 7 figures, A&A accepte
Pharmacokinetic/pharmacodynamic integration and modelling of florfenicol for the pig pneumonia pathogens Actinobacillus pleuropneumoniae and Pasteurella multocida
Pharmacokinetic-pharmacodynamic (PK/PD) integration and modelling were used to predict dosage schedules for florfenicol for two pig pneumonia pathogens, Actinobacillus pleuropneumoniae and Pasteurella multocida. Pharmacokinetic data were pooled for two bioequivalent products, pioneer and generic formulations, administered intramuscularly to pigs at a dose rate of 15 mg/kg. Antibacterial potency was determined in vitro as minimum inhibitory concentration (MIC) and Mutant Prevention Concentration in broth and pig serum, for six isolates of each organism. For both organisms and for both serum and broth MICs, average concentration:MIC ratios over 48 h were similar and exceeded 2.5:1 and times greater than MIC exceeded 35 h. From in vitro time-kill curves, PK/PD modelling established serum breakpoint values for the index AUC24h/MIC for three levels of inhibition of growth, bacteriostasis and 3 and 4log10 reductions in bacterial count; means were 25.7, 40.2 and 47.0 h, respectively, for P. multocida and 24.6, 43.8 and 58.6 h for A. pleuropneumoniae. Using these PK and PD data, together with literature MIC distributions, doses for each pathogen were predicted for: (1) bacteriostatic and bactericidal levels of kill; (2) for 50 and 90% target attainment rates (TAR); and (3) for single dosing and daily dosing at steady state. Monte Carlo simulations for 90% TAR predicted single doses to achieve bacteriostatic and bactericidal actions over 48 h of 14.4 and 22.2 mg/kg (P. multocida) and 44.7 and 86.6 mg/kg (A. pleuropneumoniae). For daily doses at steady state, and 90% TAR bacteriostatic and bactericidal actions, dosages of 6.2 and 9.6 mg/kg (P. multocida) and 18.2 and 35.2 mg/kg (A. pleuropneumoniae) were required. PK/PD integration and modelling approaches to dose determination indicate the possibility of tailoring dose to a range of end-points
Toxicokinetics of bisphenol-S and its glucuronide in plasma and urine following oral and dermal exposure in volunteers for the interpretation of biomonitoring data
The measurement of bisphenol-S (BPS) and its glucurono-conjugate (BPSG) in urine may be used for the biomonitoring of exposure in populations. However, this requires a thorough knowledge of their toxicokinetics. The time courses of BPS and BPSG were assessed in accessible biological matrices of orally and dermally exposed volunteers. Under the approval of the Research Ethics Committee of the University of Montreal, six volunteers were orally exposed to a BPS-d8 deuterated dose of 0.1 mg/kg body weight (bw). One month later, 1 mg/kg bw of BPS-d8 were applied on 40 cm2 of the forearm and then washed 6 h after application. Blood samples were taken prior to dosing and at fixed time periods over 48 h after treatment; complete urine voids were collected pre-exposure and at pre-established intervals over 72 h postdosing. Following oral exposure, the plasma concentrationâtime courses of BPS-d8 and BPSG-d8 over 48 h evolved in parallel, and showed a rapid appearance and elimination. Average peak values (±SD) were reached at 0.7 ± 0.1 and 1.1 ± 0.4 h postdosing and mean (±SD) apparent elimination half-lives (tÂœ) of 7.9 ± 1.1 and 9.3 ± 7.0 h were calculated from the terminal phase of BPS-d8 and BPSG-d8 in plasma, respectively. The fraction of BPS-d8 reaching the systemic circulation unchanged (i.e. bioavailability) was further estimated at 62 ± 5% on average (±SD) and the systemic plasma clearance at 0.57 ± 0.07 L/kg bw/h. Plasma concentrationâtime courses and urinary excretion rate profiles roughly evolved in parallel for both substances, as expected. The average percent (±SD) of the administered dose recovered in urine as BPS-d8 and BPSG-d8 over the 0â72 h period postdosing was 1.72 ± 1.3 and 54 ± 10%. Following dermal application, plasma levels were under the lower limit of quantification (LLOQ) at most time points. However, peak values were reached between 5 and 8 h depending on individuals, suggesting a slower absorption rate compared to oral exposure. Similarly, limited amounts of BPS-d8 and its conjugate were recovered in urine and peak excretion rates were reached between 5 and 11 h postdosing. The average percent (±SD) of the administered dose recovered in urine as BPS-d8 and BPSG-d8 was about 0.004 ± 0.003 and 0.09 ± 0.07%, respectively. This study provided greater precision on the kinetics of this contaminant in humans and, in particular, evidenced major differences between BPA and BPS kinetics with much higher systemic levels of active BPS than BPA, an observation explained by a higher oral bioavailability of BPS than BPA. These data should also be useful in developing a toxicokinetic model for a better interpretation of biomonitoring data
The non-detection of oscillations in Procyon by MOST: is it really a surprise?
We argue that the non-detection of oscillations in Procyon by the MOST
satellite reported by Matthews et al. (2004) is fully consistent with published
ground-based velocity observations of this star. We also examine the claims
that the MOST observations represent the best photometric precision so far
reported in the literature by about an order of magnitude and are the most
sensitive data set for asteroseismology available for any star other than the
Sun. These statements are not correct, with the most notable exceptions being
observations of oscillations in alpha Cen A that are far superior. We further
disagree that the hump of excess power seen repeatedly from velocity
observations of Procyon can be explained as an artefact caused by gaps in the
data. The MOST observations failed to reveal oscillations clearly because their
noise level is too high, possibly from scattered Earthlight in the instrument.
We did find an excess of strong peaks in the MOST amplitude spectrum that is
inconsistent with a simple noise source such as granulation, and may perhaps
indicate oscillations at roughly the expected level.Comment: 6 pages, accepted for publication in A&A Letter
Solar-like oscillations with low amplitude in the CoRoT target HD 181906
Context: The F8 star HD 181906 (effective temperature ~6300K) was observed
for 156 days by the CoRoT satellite during the first long run in the centre
direction. Analysis of the data reveals a spectrum of solar-like acoustic
oscillations. However, the faintness of the target (m_v=7.65) means the
signal-to-noise (S/N) in the acoustic modes is quite low, and this low S/N
leads to complications in the analysis. Aims: To extract global variables of
the star as well as key parameters of the p modes observed in the power
spectrum of the lightcurve. Methods: The power spectrum of the lightcurve, a
wavelet transform and spot fitting have been used to obtain the average
rotation rate of the star and its inclination angle. Then, the autocorrelation
of the power spectrum and the power spectrum of the power spectrum were used to
properly determine the large separation. Finally, estimations of the mode
parameters have been done by maximizing the likelihood of a global fit, where
several modes were fit simultaneously. Results: We have been able to infer the
mean surface rotation rate of the star (~4 microHz) with indications of the
presence of surface differential rotation, the large separation of the p modes
(~87 microHz), and therefore also the ridges corresponding to overtones of the
acoustic modes.Comment: Paper Accepted to be published in A&A. 10 Pages, 12 figure
Xq27 FRAXA locus is a strong candidate for dyslexia: evidence from a genome-wide scan in French families.
Dyslexia is a frequent neurodevelopmental
learning disorder. To date, nine susceptibility loci have
been identified, one of them being DYX9, located in Xq27.
We performed the first French SNP linkage study followed
by candidate gene investigation in dyslexia by studying 12
multiplex families (58 subjects) with at least two children
affected, according to categorical restrictive criteria for
phenotype definition. Significant results emerged on
Xq27.3 within DYX9. The maximum multipoint LOD
score reached 3,884 between rs12558359 and rs454992.
Within this region, seven candidate genes were investigated
for mutations in exonic sequences (CXORF1,
CXORF51, SLITRK2, FMR1, FMR2, ASFMR1, FMR1NB),
all having a role during brain development. We further
looked for 50
UTR trinucleotide repeats in FMR1 and FMR2
genes. No mutation or polymorphism co-segregating with
dyslexia was found. This finding in French families with
Dyslexia showed significant linkage on Xq27.3 enclosing
FRAXA, and consequently confirmed the DYX9 region as
a robust susceptibility locus. We reduced the previously
described interval from 6.8 (DXS1227âDXS8091) to 4 Mb
also disclosing a higher LOD score
The quest for the solar g modes
Solar gravity modes (or g modes) -- oscillations of the solar interior for
which buoyancy acts as the restoring force -- have the potential to provide
unprecedented inference on the structure and dynamics of the solar core,
inference that is not possible with the well observed acoustic modes (or p
modes). The high amplitude of the g-mode eigenfunctions in the core and the
evanesence of the modes in the convection zone make the modes particularly
sensitive to the physical and dynamical conditions in the core. Owing to the
existence of the convection zone, the g modes have very low amplitudes at
photospheric levels, which makes the modes extremely hard to detect. In this
paper, we review the current state of play regarding attempts to detect g
modes. We review the theory of g modes, including theoretical estimation of the
g-mode frequencies, amplitudes and damping rates. Then we go on to discuss the
techniques that have been used to try to detect g modes. We review results in
the literature, and finish by looking to the future, and the potential advances
that can be made -- from both data and data-analysis perspectives -- to give
unambiguous detections of individual g modes. The review ends by concluding
that, at the time of writing, there is indeed a consensus amongst the authors
that there is currently no undisputed detection of solar g modes.Comment: 71 pages, 18 figures, accepted by Astronomy and Astrophysics Revie
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